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Population pharmacokinetics of primaquine and its metabolites in African males
BackgroundPrimaquine (PQ) is the prototype 8-aminoquinoline drug, a class which targets gametocytes and hypnozoites. The World Health Organization...
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Addressing the disparities: the approach to the African American patient with multiple myeloma
There are significant disparities with regards to incidence, timely diagnosis, access to treatment, clinical trial participation and health care...
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African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans
BackgroundAsthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with...
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STAC3 disorder: a common cause of congenital hypotonia in Southern African patients
STAC3 disorder, or Native American myopathy, is characterised by congenital myopathy, hypotonia, musculoskeletal and palatal anomalies, and...
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Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture
We explored ancestry-related differences in the genetic architecture of whole-blood gene expression using whole-genome and RNA sequencing data from...
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ANO7 African-ancestral genomic diversity and advanced prostate cancer
BackgroundProstate cancer (PCa) is a significant health burden for African men, with mortality rates more than double global averages. The prostate...
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A large population sample of African HIV genomes from the 1980s reveals a reduction in subtype D over time associated with propensity for CXCR4 tropism
We present 109 near full-length HIV genomes amplified from blood serum samples obtained during early 1986 from across Uganda, which to our knowledge...
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Beliefs and knowledge related to human papillomavirus (HPV) vaccine among African Americans and African immigrants young adults
BackgroundDespite the disparate human papillomavirus (HPV) infection rates among sexually active Black young adults, HPV vaccine uptake remains low...
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Breast cancer among African American and sub-Saharan African women: a tale of global inequities
Breast Cancer is the most common female cancer worldwide with significant global disparities, particularly disadvantaging women of African Ancestry....
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A genome-wide association study of neutrophil count in individuals associated to an African continental ancestry group facilitates studies of malaria pathogenesis
Background'Benign ethnic neutropenia' (BEN) is a heritable condition characterized by lower neutrophil counts, predominantly observed in individuals...
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African American Women Breast Cancer Survivors: Co** with the COVID-19 Pandemic
African American women breast cancer survivors are among those with the greater burden of cancer. Breast cancer is the second leading cause of death...
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Benign breast disease and breast cancer risk in African women: a case–control study
PurposeTo examine the association between benign breast disease (BBD) and breast cancer (BC) in a heterogeneous population of African women.
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Human African Trypanosomiasis (HAT)
Human African Trypanosomiasis (HAT) found only in sub-Saharan Africa is caused by the parasite Trypanosoma brucei, which is transmitted by tsetse...
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Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction
We performed genome-wide association studies of breast cancer including 18,034 cases and 22,104 controls of African ancestry. Genetic variants at 12...
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Immunoexpression of neuropilin-1 in the chorionic villi of HIV-infected preeclamptic South African women of African ancestry
Neuropilin-1 (NRP-1) is an essential regulator of maternal immune tolerance, placentation, and angiogenesis. Its dysregulation in preeclampsia (PE)...
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Transferability of genetic risk scores in African populations
The poor transferability of genetic risk scores (GRSs) derived from European ancestry data in diverse populations is a cause of concern. We set out...
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High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response
How human genetic variation contributes to vaccine effectiveness in infants is unclear, and data are limited on these relationships in populations...
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Association of Preventive Care Attitudes and Beliefs with Colorectal Cancer Screening History among African American Patients of Community Health Centers
Colorectal cancer (CRC) is the third most common cancer and third leading cause of cancer-related death among African Americans in the United States....
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Genomic insights into Plasmodium vivax population structure and diversity in central Africa
BackgroundThough Plasmodium vivax is the second most common malaria species to infect humans, it has not traditionally been considered a major human...
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Drivers of autochthonous malaria cases over time: could the Central European present the African future?
BackgroundResults of spatial and temporal comparison of malaria hotspots and coldspots could improve the health measures of malaria control and...
