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Outcomes of patients in nasopharyngeal adenoid cystic carcinoma in the IMRT era: a single-center experience
ObjectiveNasopharyngeal adenoid cystic carcinoma (NACC) is a rare malignancy with special biological features. Controversies exist regarding the...
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Long-term outcomes after particle radiation therapy in patients with nasopharyngeal adenoid cystic carcinoma
BackgroundNasopharyngeal adenoid cystic carcinoma (NACC) is a relatively rare salivary gland tumor that is generally associated with poor outcomes....
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Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy
Breast adenoid cystic carcinoma (AdCC) is a rare subtype of triple negative breast cancer. Two morphologic variants are described, namely classic...
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Role of postoperative radiotherapy in resected adenoid cystic carcinoma of the head and neck
PurposeAlthough postoperative radiotherapy (PORT) is demonstrably effective in local control of head and neck adenoid cystic carcinoma (HNACC), its...
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EN1 promotes lung metastasis of salivary adenoid cystic carcinoma by regulating the PI3K-AKT pathway and epithelial-mesenchymal transition
BackgroundEngrailed homeobox 1 ( EN1 ) is a candidate oncogene that is epigenetically modified in salivary adenoid cystic carcinoma (SACC). We...
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Increased retinoic acid signaling decreases lung metastasis in salivary adenoid cystic carcinoma by inhibiting the noncanonical Notch1 pathway
MYB-NFIB fusion and NOTCH1 mutation are common hallmark genetic events in salivary gland adenoid cystic carcinoma (SACC). However, abnormal...
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Definitive carbon ion radiotherapy for tracheobronchial adenoid cystic carcinoma: a preliminary report
BackgroundTracheobronchial adenoid cystic carcinoma (TACC) is a rare tumour. About one-third of patients miss their chance of surgery or complete...
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Adenoid cystic Carcinoma and Carbon ion Only irradiation (ACCO): Study protocol for a prospective, open, randomized, two-armed, phase II study
BackgroundAdenoid cystic carcinoma is a rare form of head and neck cancer with a slow, but aggressive growth pattern which remains a challenge for...
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Clinical features, treatment and outcomes in patients with tracheal adenoid cystic carcinoma: a systematic literature review
BackgroundPrimary tracheal adenoid cystic carcinoma (TACC) is rare and originates from the minor salivary gland. Biologically, TACC results in...
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Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma
BackgroundPatients were prone to have poor prognosis once dormant tumor cells being reactivated. However, the molecular mechanism of tumor cell...
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Ultrasonography characteristics of cystic components in primary salivary gland tumors
ObjectivesThe present study aimed to characterize the ultrasonography (US) features of cystic components in salivary gland tumors (SGTs).
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Expression profile of circular RNA and construction of circular RNA-Micro RNA network in salivary adenoid cystic carcinoma
BackgroundCircular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types...
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Phase 1 safety and pharmacodynamic study of lenalidomide combined with everolimus in patients with advanced solid malignancies with efficacy signal in adenoid cystic carcinoma
BackgroundPurpose: The combination of a mammalian target of rapamycin inhibitor and lenalidomide showed enhanced preclinical cytotoxicity. We...
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Prostate-specific membrane antigen (PSMA) expression in adenoid cystic carcinoma of the head and neck
BackgroundTreatment options for advanced head and neck adenoid cystic carcinoma (AdCC) are limited. Prostate-Specific Membrane Antigen (PSMA), a...
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Rare subtypes of triple negative breast cancer: Current understanding and future directions
Rare subtypes of triple-negative breast cancers (TNBC) are a heterogenous group of tumors, comprising 5–10% of all TNBCs. Despite accounting for an...
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Nectin-4 is frequently expressed in primary salivary gland cancer and corresponding lymph node metastases and represents an important treatment-related biomarker
Many locally advanced and metastatic salivary gland carcinomas (SGC) lack therapeutic targets. Enfortumab vedotin , an antibody–drug conjugate binding...
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Histopathological Characteristics: Breast Cancer Subtypes Depending on Receptor Status, Clinical and Pathological Staging of Breast Cancer
Breast cancer (BC) is a clinically heterogeneous disease affecting around 14% female population worldwide with unique histopathological and...
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Molecular detection of human papillomavirus-16 among Sudanese patients diagnosed with squamous cell carcinoma and salivary gland carcinoma
ObjectiveHuman papillomavirus (HPV) gained momentum as a potential etiological factor for many types of cancers. Therefore, the aim of this study...
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The Role of Immune Checkpoint Inhibitors in the Treatment of Less Common Head and Neck Cancers
The role of immune checkpoint inhibitors in less common head and neck cancers, including non-squamous cell carcinoma, is less known. This chapter...