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Understanding adefovir pharmacokinetics as a component of a transporter phenoty** cocktail
PurposeAdefovir (as dipivoxil) was selected as a probe drug in a previous transporter cocktail phenoty** study to assess renal organic anion...
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Effect of Coformer Selection on In Vitro and In Vivo Performance of Adefovir Dipivoxil Cocrystals
PurposeThis study aimed to improve the in vitro dissolution, permeability and oral bioavailability of adefovir dipivoxil (ADD) by cocrystal...
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Stabilized oral nanostructured lipid carriers of Adefovir Dipivoxil as a potential liver targeting: Estimation of liver function panel and uptake following intravenous injection of radioiodinated indicator
PurposeAdefovir dipivoxil (AD), a nucleoside reverse transcriptase inhibitor is effective against Hepatitis B virus. Its poor oral bioavailability...
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Osteomalacia and renal failure due to Fanconi syndrome caused by long-term low-dose Adefovir Dipivoxil: a case report
BackgroundProgressive bone pain and fracture and abnormal positron emission tomography combined with a computed tomography are main reasons for the...
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Role of plasmatic and urinary concentration of tenofovir disoproxil fumarate in a cohort of patients affected by chronic hepatitis B
The aim of this study was to evaluate plasmatic and urinary therapeutic drug monitoring (TDM) of tenofovir disoproxil fumarate (TDF) in a cohort of...
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Mitigating Drug Stability Challenges Through Cocrystallization
Drug stability plays a significant role in the pharmaceutical industry from early-phase drug discovery to product registration as well as the entire...
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Cross-sectional retrospective analysis of clinical characteristics of chronic hepatitis B patients with oral antiviral treatment in eastern China
BackgroundIn China, more than 20 million patients with chronic hepatitis B need antiviral treatment. Side effects of antiviral treatment such as...
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Creatine kinase elevation in chronic hepatitis B patients with telbivudine therapy: influence of telbivudine plasma concentration and single nucleotide polymorphisms of TK2, RRM2B, and NME4
PurposeTo study the correlations of genetic variants of telbivudine phosphorylase kinases and telbivudine plasma concentration with creatine kinase...
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Phosphoryl prodrugs: characteristics to improve drug development
Phosphoryl prodrugs are key compounds in drug development. Biologically active phosphoryl compounds often have negative charges on the phosphoryl...
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Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: a comparative study of Chinese and foreign case series
BackgroundAdefovir dipivoxil (ADV)-induced renal tubular dysfunction and hypophosphatemic osteomalacia (HO) have been given great consideration in...
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Liquid antisolvent crystallization of pharmaceutical compounds: current status and future perspectives
The present work reviews the liquid antisolvent crystallization (LASC) to prepare the nanoparticle of pharmaceutical compounds to enhance their...
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Antivirals: Approaches and the Way Forward
Viral diseases pose significant challenges in human and veterinary medicine, as effective treatment options are limited. The development of antiviral...
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Seroprevalence and genotypic characterization of HBV among low risk voluntary blood donors in Nairobi, Kenya
BackgroundHepatitis B virus (HBV) causes significant morbidity and mortality globally primarily due to its ability to cause hepatitis, liver...
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The antiviral potential of Phyllanthus species: a systematic review
Viral infections and diseases caused by viruses are worldwide problems. According to a WHO report, three to five million people are chronically...
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Synergistic Herb-Drug Interactions Against Viral Diseases
Emerging or reemerging viruses are of serious concern as they are associated with higher degree of mortality and deleterious impact on human life....
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Antiviral Drugs
Viruses are obligate intracellular organisms. They require host cell for replication process. Different classes of drugs are available for targeting...
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Cocrystallization and Coamorphization for Druggability Enhancement of Chinese Medicines
Cocrystallization and coamorphization techniques incorporating active ingredient of Chinese medicine and an or more appropriate coformer(s) into a...
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Genotype and Phenotype of Renal Hypouricemia: A Single-Center Study from China
BackgroundRenal hypouricemia (RHUC), a rare inherited disorder characterized by impaired uric acid reabsorption and subsequent profound hypouricemia,...
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Primary non-response to antiviral therapy affects the prognosis of hepatitis B virus-related hepatocellular carcinoma
Background and aimAlthough antiviral treatments have been shown to affect the recurrence and long-term survival of patients with hepatocellular...
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Nanomedicines to Improve Oral Delivery of Antiretroviral Drugs
Over the years, oral drug delivery has been the route of choice for drug administration, and with no exception, the marketed antiretroviral...