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Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis
Microglia are scavengers of the brain environment that clear dead cells, debris, and microbes. In Alzheimer’s disease, microglia get activated to...
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β-Actin: An Emerging Biomarker in Ischemic Stroke
At present, the diagnosis of ischemic stroke mainly depends on neuroimaging technology, but it still has many limitations. Therefore, it is very...
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Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes
Mutations in the α-Synuclein (αS) gene promote αS monomer aggregation that causes neurodegeneration in familial Parkinson’s disease (fPD). However,...
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Electrical Propagation of Condensed and Diffuse Ions Along Actin Filaments
In this article, we elucidate the roles of divalent ion condensation and highly polarized immobile water molecules on the propagation of ionic...
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Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling
BackgroundAbnormal proliferation and migration of cells are hallmarks of cancer initiation and malignancy. Asparagine endopeptidase (AEP) has...
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Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo
BackgroundMutations in LRRK2 are the most common cause of familial Parkinson’s disease and typically cause disease in the context of abnormal...
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Human deafness-associated variants alter the dynamics of key molecules in hair cell stereocilia F-actin cores
Stereocilia protrude up to 100 µm from the apical surface of vertebrate inner ear hair cells and are packed with cross-linked filamentous actin...
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Generation and Characterization of a Skeletal Muscle Cell-Based Model Carrying One Single Gne Allele: Implications in Actin Dynamics
UDP-N-Acetyl glucosamine-2 epimerase/N-acetyl mannosamine kinase (GNE) catalyzes key enzymatic reactions in the biosynthesis of sialic acid. Mutation...
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α-Linolenic acid induces clearance of Tau seeds via Actin-remodeling in Microglia
Alzheimer’s disease (AD) is known by characteristic features, extracellular burden of amyloid-β and intracellular neuronal Tau. Microglia, the innate...
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Internalization and Endosomal Trafficking of Extracellular Tau in Microglia Improved by α-Linolenic Acid
Alzheimer’s disease (AD) is distinguished by extracellular accumulation of amyloid-beta plaques and intracellular neurofibrillary tangles of Tau....
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A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity
BackgroundGlioma is one of the most aggressive malignant brain tumors that is characterized with inevitably infiltrative growth and poor prognosis....
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Tools of the trade: studying actin in zebrafish
Actin is a conserved cytoskeletal protein with essential functions. Here, we review the state-of-the-art reagents, tools and methods used to probe...
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Actin as a Target to Reduce Cell Invasiveness in Initial Stages of Metastasis
We demonstrate the relative roles of the cell cytoskeleton, and specific importance of actin in facilitating mechanical aspects of metastatic...
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How Actin Tracks Affect Myosin Motors
Cellular organization through cytoskeletal trafficking is a process of fundamental importance. Highly specialized systems evolved that enable motors...
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A yeast based assay establishes the pathogenicity of novel missense ACTA2 variants associated with aortic aneurysms
The ACTA2 gene codes for alpha-smooth muscle actin, a critical component of the contractile apparatus of the vascular smooth muscle cells. Autosomal...
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The effects of 808-nm near-infrared laser light irradiation on actin cytoskeleton reorganization in bone marrow mesenchymal stem cells
Tailoring the cell organelles and thus changing cell homeostatic behavior has permitted the discovery of fascinating metabolic features enabling...
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Caveolin-1 in Müller Glia Exists as Heat-Resistant, High Molecular Weight Complexes
Caveolin-1 (Cav1), the core structural and scaffolding protein of caveolae membrane domains, is highly expressed in many retinal cells and is...
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The Regulation of GLT-1 Degradation Pathway by SIRT4
Glial cells give rise to glioblastoma multiform as a primary brain tumor. In glioblastomas, neurons are destroyed via excitotoxicity which is the...
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Common and unique mechanisms of filamentous actin formation by viruses of the genus Orthorubulavirus
We previously found that infection with human parainfluenza virus type 2 (hPIV-2), a member of the genus Orthorubulavirus, family Paramyxoviridae ,...
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Rat corneal endothelial cell migration during wound repair on the basement membrane depends more on the PI-3K pathway than the cdc-42 pathway or actin stress fibers
Following a central transcorneal circular freeze injury, organ-cultured rat corneal endothelial cells surrounding the wound reorganize peripheral...
