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The role of acid-sensing ion channels in monosodium urate-induced gouty pain in mice
Acid-sensing ion channels (ASICs) in dorsal root ganglion (DRG) neurons play an important role in inflammatory pain. The objective of this study is...
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Methyl Ferulic Acid Alleviates Neuropathic Pain by Inhibiting Nox4-induced Ferroptosis in Dorsal Root Ganglia Neurons in Rats
Neuropathic pain is a disease that has become one of the major public health problems and a global burden. Nox4-induced oxidative stress can lead to...
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Modulatory Processes in Craniofacial Pain States
Pain is a common symptom associated with many disorders affecting the craniofacial tissues that include the teeth and their supporting structures,...
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Preventive Anti-inflammatory Effects of Apocynin on Acetic Acid–Induced Colitis in Rats
Ulcerative colitis is an inflammatory bowel disease with a complex aetiology characterised by abnormal immune responses and oxidative stress–induced...
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Inflammation and Pain
Inflammation is the body’s natural response to injury or the infiltration of a foreign substance. The process is defined by five cardinal signs:...
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Pain Disorders other than Migraine
Following injection into the muscle or skin, botulinum toxin blocks the release of pain transmitters and modulators and lead to reduction of pain...
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Suberoylanilide Hydroxamic Acid Ameliorates Pain Sensitization in Central Neuropathic Pain After Spinal Cord Injury via the HDAC5/NEDD4/SCN9A Axis
Pain sensitization in spinal cord injury (SCI)-induced central neuropathic pain has been a research target. Additionally, suberoylanilide hydroxamic...
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Mechanisms-Based Pain Therapies
Chronic pain is a prevalent disease with high impact on public health and individual’s quality of life. Understanding the complex mechanisms and...
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Immunotherapy and Pain
Immunotherapy was initially developed as a method to treat cancer through the use of the host’s immune system. Now, immunotherapy is used as a...
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Pain
Pain is one of the most common causes of suffering. The physiological function of pain is to alert the body of potentially noxious conditions...
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Cytochrome P450 26A1 Contributes to the Maintenance of Neuropathic Pain
The cytochrome P450 proteins (CYP450s) have been implicated in catalyzing numerous important biological reactions and contribute to a variety of...
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Precision Medicine in Neuropathic Pain
Neuropathic pain is a common chronic pain condition that is caused by a lesion or disease of the somatosensory nervous system. The multitude of...
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Inflammatory Mediators, Nociceptors, and Their Interactions in Pain
Inflammation produces pro-inflammatory mediators for the induction of pain. These mediators include inflammatory cytokines and chemokines, lipids,...
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Licofelone Attenuates Acetic Acid-Induced Colitis in Rats Through Suppression of the Inflammatory Mediators
Licofelone is a dual Cyclooxygenase 1,2 (COX1,2)/5-lipoxygenase) 5-LOX (inhibitor with analgesic and anti-inflammatory effects with possible...
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Anti-inflammatory activity of peiminine in acetic acid-induced ulcerative colitis model
Ulcerative colitis is a chronic inflammatory disorder of the intestinal mucosa and a prevalent gastrointestinal condition in developed countries....
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Interstitial Cystitis/Bladder Pain Syndrome
Painful bladder syndrome or interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic debilitating disease, defined by a variable combination...
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Current Understanding of DNA Methylation in the Pathogenesis of Neuropathic Pain
Lesion or disease in the somatosensory nervous system is the root cause of neuropathic pain, which has a major negative influence on the quality of...
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Synergistic effect of ellagic acid and gabapentin in a rat model of neuropathic pain
Background : Neuropathic pain is a subtype of chronic pain characterized by a primary lesion or dysfunction of the peripheral or central nervous...
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Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain
Abdominal pain is one of the main symptoms of chronic gastrointestinal disorders including inflammatory bowel diseases (IBD) and irritable bowel...
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Novel antiarthritic mechanisms of Azelaic acid against CFA-induced arthritis in rats by modulating pro- and anti-inflammatory cytokines network
An immunologic system attacking the body’s own tissues is a hallmark of autoimmune disorders, which encompass a wide range of unique conditions....
