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Acetylation of c-Myc at Lysine 148 Protects Neurons After Ischemia
This study focuses on understanding the role of c-Myc, a cancer-associated transcription factor, in the penumbra following ischemic stroke. While its...
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Microtubule acetylation dyshomeostasis in Parkinson’s disease
AbstractThe inter-neuronal communication occurring in extensively branched neuronal cells is achieved primarily through the microtubule (MT)-mediated...
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Acetylation of p53 in the Cerebral Cortex after Photothrombotic Stroke
p53 expression and acetylation are crucial for the survival and death of neurons in penumbra. At the same time, the outcome of ischemia for penumbra...
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Insertion of short L1 sequences generates inter-strain histone acetylation differences in the mouse
BackgroundGene expression divergence between populations and between individuals can emerge from genetic variations within the genes and/or in the cis ...
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Histone acetylation: a key determinant of acquired cisplatin resistance in cancer
Cisplatin is an alkylating class of chemotherapeutic drugs used to treat cancer patients. However, cisplatin fails in long-term treatment, and drug...
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Per-cell histone acetylation is associated with terminal differentiation in human T cells
BackgroundEpigenetic remodeling at effector gene loci has been reported to be critical in regulating T cell differentiation and function. However,...
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Lactate as a major epigenetic carbon source for histone acetylation via nuclear LDH metabolism
Histone acetylation involves the transfer of two-carbon units to the nucleus that are embedded in low-concentration metabolites. We found that...
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Acetylation of FOXO1 activates Bim expression involved in CVB3 induced cardiomyocyte apoptosis
Viral myocarditis (VMC) is the major reason for sudden cardiac death among both children and young adults. Of these, coxsackievirus B3 (CVB3) is the...
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PDHE1α in DNA damage repair: a critical chromatin acetylation regulator
A recent study in Nature Structural and Molecular Biology reveals that chromatin-associated PDHE1α generates acetyl-CoA near DNA double-strand...
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H3K4 Trimethylation Mediate Hyperhomocysteinemia Induced Neurodegeneration via Suppressing Histone Acetylation by ANP32A
Homocysteine (Hcy) is an independent and serious risk factor for dementia, including Alzheimer’s disease (AD), but the precise mechanisms are still...
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α-Catenin acetylation is essential for its stability and blocks its tumor suppressor effects in breast cancer through Yap1
α-Catenin plays a critical role in tissue integrity, repair, and embryonic development. However, the post-translational modifications of α-catenin...
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Quantitative analysis of acetylation in peste des petits ruminants virus-infected Vero cells
BackgroundPeste des petits ruminants virus (PPRV) is a highly contagious pathogen that strongly influences the productivity of small ruminants...
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ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease
BackgroundNuclear acetyl-CoA pools govern histone acetylation that controls synaptic plasticity and contributes to cognitive deterioration in...
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Changes in histone lysine acetylation, but not DNA methylation during facultative hibernation in Syrian hamster liver
BackgroundHibernation (torpor) is a strategy to survive extreme environmental conditions, associated with a significant decrease in metabolism and...
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ACAT1-mediated METTL3 acetylation inhibits cell migration and invasion in triple negative breast cancer
Triple-negative breast cancer (TNBC) is a heterogeneous and aggressive disease with poor prognosis. Acetylation modifications affect a great number...
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The CDK4/6 Inhibitor Palbociclib Induces Cell Senescence of High-grade Serous Ovarian Cancer Through Acetylation of p53
AbstractCell senescence is an anti-cancer strategy following DNA repair and apoptosis, which is associated with the initiation, progression, and...
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Histone acetylation in an Alzheimer’s disease cell model promotes homeostatic amyloid-reducing pathways
Alzheimer’s Disease (AD) is a disorder characterized by cognitive decline, neurodegeneration, and accumulation of amyloid plaques and tau...
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ENPP1 inhibits the transcription activity of the hepatitis B virus pregenomic promoter by upregulating the acetylation of LMNB1
Current therapies for hepatitis B virus (HBV) infection can slow disease progression but cannot cure the infection, as it is difficult to eliminate...
