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Possible implication of miR-142-3p in coronary microembolization induced myocardial injury via ATXN1L/HDAC3/NOL3 axis
AbstractThis study aims to explore the mechanism underlying miR-142-3p regulating myocardial injury induced by coronary microembolization (CME)...
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Novel ATXN1/ATXN1L::NUTM2A fusions identified in aggressive infant sarcomas with gene expression and methylation patterns similar to CIC-rearranged sarcoma
CIC -rearranged sarcomas are newly defined undifferentiated soft tissue tumors with CIC- associated fusions, and dismal prognosis. CIC fusions activate...
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Functional implications of paralog genes in polyglutamine spinocerebellar ataxias
Polyglutamine (polyQ) spinocerebellar ataxias (SCAs) comprise a group of autosomal dominant neurodegenerative disorders caused by (CAG/CAA) n ...
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MicroRNA-136-5p protects cardiomyocytes from coronary microembolization through the inhibition of pyroptosis
This study investigated how miR-136-5p partially affected cardiomyocyte pyroptosis in rats with coronary microembolization (CME). The cardiac...
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CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
Capicua (CIC) is an important downstream molecule of RTK/RAS/MAPK pathway. The regulatory mechanism of CIC underlying tumorigenesis in...
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Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain
RNA interference (RNAi) for spinocerebellar ataxia type 1 can prevent and reverse behavioral deficits and neuropathological readouts in mouse models,...
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Regulation and function of capicua in mammals
Capicua (CIC) is an evolutionarily conserved transcription factor. CIC contains a high-mobility group (HMG) box that recognizes specific DNA...
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ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms
BackgroundWild-type (wt) polyglutamine (polyQ) regions are implicated in stabilization of protein-protein interactions (PPI). Pathological polyQ...
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Analysis of 3760 hematologic malignancies reveals rare transcriptomic aberrations of driver genes
BackgroundRare oncogenic driver events, particularly affecting the expression or splicing of driver genes, are suspected to substantially contribute...
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Correction to: Evolutionarily novel genes are expressed in transgenic fish tumors and their orthologs are involved in development of progressive traits in humans
The original publication of this article [1] contained 4 errors in column 1 of Table 4. In this correction article the errors and updated table are...
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Comprehensive profiling and characterization of cellular microRNAs in response to coxsackievirus A10 infection in bronchial epithelial cells
Coxsackievirus A10 (CV-A10), the causative agent of hand, foot, and mouth disease (HFMD), caused a series of outbreaks in recent years and often...
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Adeno-associated virus vectors and neurotoxicity—lessons from preclinical and human studies
Over 15 years after hepatotoxicity was first observed following administration of an adeno-associated virus (AAV) vector during a hemophilia B...
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Extracellular Vesicles Isolated from Human Induced Pluripotent Stem Cell-Derived Neurons Contain a Transcriptional Network
Healthy brain function is mediated by several complementary signalling pathways, many of which are driven by extracellular vesicles (EVs). EVs are...
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Molecular Mechanisms of Spinocerebellar Ataxia Type 1
AbstractPolyglutamine (polyQ) disorders are severe forms of inherited neurodegenerative pathologies caused by the expansion of CAG repeats in...
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Evolutionarily novel genes are expressed in transgenic fish tumors and their orthologs are involved in development of progressive traits in humans
AbstractEarlier we suggested a new hypothesis of the possible evolutionary role of hereditary tumors (Kozlov, Evolution by tumor...
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Specific phenotype semantics facilitate gene prioritization in clinical exome sequencing
Selection and prioritization of phenotype-centric variants remains a challenging part of variant analysis and interpretation in clinical exome...
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DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns
BackgroundMultiple epigenome-wide association studies have been performed to identify DNA methylation patterns regulated by aging or correlated with...
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Development and validation of GMI signature based random survival forest prognosis model to predict clinical outcome in acute myeloid leukemia
BackgroundAcute myeloid leukemia (AML) is a disease with marked molecular heterogeneity and a high early death rate. Our aim was to investigate an...
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Disruption of the ATXN1–CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans
Gain-of-function mutations in some genes underlie neurodegenerative conditions, whereas loss-of-function mutations in the same genes have distinct...
