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C-subfamily ATP binding cassette transporters extrude the calcium fluorescent probe fluo-4 from a cone photoreceptor cell line
Whole transcriptome sequencing has revealed the existence of mRNAs for multiple membrane transporters in photoreceptors. Except for ATP binding...
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COVID-19 drugs: potential interaction with ATP-binding cassette transporters P-glycoprotein and breast cancer resistance protein
BackgroundThe coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2, has resulted in acute...
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Maternal and Fetal Expression of ATP-Binding Cassette and Solute Carrier Transporters Involved in the Brain Disposition of Drugs
Evidence from preclinical and clinical studies demonstrate that pregnancy is a physiological state capable of modifying drug disposition. Factors...
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The ATP-Binding Cassette Transporter-Mediated Efflux Transport of Ganciclovir at the Blood–Brain Barrier
Background and ObjectiveRecent studies have highlighted the key role of the ATP-binding cassette (ABC) transporters, including the P-glycoprotein...
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Isocitrate dehydrogenase 2 inhibitor enasidenib synergizes daunorubicin cytotoxicity by targeting aldo-keto reductase 1C3 and ATP-binding cassette transporters
Targeting mutations that trigger acute myeloid leukaemia (AML) has emerged as a refined therapeutic approach in recent years. Enasidenib (Idhifa) is...
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Drug Transporters
Membrane transporters play a central role in protecting the body from xenobiotics (either by preventing their absorption, limiting their...
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The role of ATP-binding cassette subfamily A in the etiology of Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is the leading cause of dementia, clinically characterized by memory deficits and progressive cognitive decline....
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Combined effects of microplastics and methylmercury on the activity of ATP-binding cassette (ABC) transporter in the brackish water flea Diaphanosoma celebensis
ObjectivesDue to their widespread presence, persistence, and bioaccumulation in living organisms, microplastics (MP) and methylmercury (MeHg)...
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Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters
Cancer cells frequently display intrinsic or acquired resistance to chemically diverse anticancer drugs, limiting therapeutic success. Among the main...
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Regulation of ABC transporters by sex steroids may explain differences in drug resistance between sexes
Drug efficacy is dependent on the pharmacokinetics and pharmacodynamics of therapeutic agents. Tight junctions, detoxification enzymes, and drug...
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Membrane transporters in drug development and as determinants of precision medicine
The effect of membrane transporters on drug disposition, efficacy and safety is now well recognized. Since the initial publication from the...
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Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters
The vitamin D receptor (VDR), in addition to other nuclear receptors, the pregnane X receptor (PXR) and constitutive androstane receptor (CAR), is...
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Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease
Membrane transporters such as ATP-binding cassette (ABC) and solute carrier (SLC) transporters expressed at the neurovascular unit (NVU) play an...
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Pharmacogenomics in Drug Metabolism Enzymes and Transporters
The safe and effective use of drug therapies play a critical role in treating disease. Interindividual variability in drug metabolism and transport...
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Knockout Transporter Cell Lines to Assess Substrate Potential Towards Efflux Transporters
P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance transporter 2 (MRP2) are efflux transporters involved in the...
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Drug Metabolizing Enzymes and Transporters of the Mesentery
Recent research has shown that the mesentery, which was classified as a new organ in 2016, is indeed an unfragmented structure. The mesentery is now...
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Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer
BackgroundAlthough gemcitabine has been considered as the first-line drug for advanced pancreatic cancer (PC), development of resistance to...
