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Complex alterations in inflammatory pain and analgesic sensitivity in young and ageing female rats: involvement of ASIC3 and Nav1.8 in primary sensory neurons
Objective and designOur aim was to determine an age-dependent role of Nav1.8 and ASIC3 in dorsal root ganglion (DRG) neurons in a rat pre-clinical...
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Inhibiting BDNF/TrkB.T1 receptor improves resiniferatoxin-induced postherpetic neuralgia through decreasing ASIC3 signaling in dorsal root ganglia
BackgroundPostherpetic neuralgia (PHN) is a devastating complication after varicella-zoster virus infection. Brain-derived neurotrophic factor (BDNF)...
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Aggressive migration in acidic pH of a glioblastoma cancer stem cell line in vitro is independent of ASIC and KCa3.1 ion channels, but involves phosphoinositide 3-kinase
The microenvironment of proliferative and aggressive tumours, such as the brain tumour glioblastoma multiforme (GBM), is often acidic, hypoxic, and...
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Targeting Acid-Sensing Ion Channels in Disease
Acidosis is a central feature of many pathological conditions, and while the activity of many ion channels is suppressed under acidic conditions,...
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Acid-sensing ion channels and downstream signalling in cancer cells: is there a mechanistic link?
It is increasingly appreciated that the acidic microenvironment of a tumour contributes to its evolution and clinical outcomes. However, our...
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Functional characterization of acid-sensing ion channels in the cerebellum-originating medulloblastoma cell line DAOY and in cerebellar granule neurons
Acid-sensing ion channels (ASICs) are Na + channels that are almost ubiquitously expressed in neurons of the brain. Functional ASIC1a is also...
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Capsazepine decreases corneal pain syndrome in severe dry eye disease
BackgroundDry eye disease (DED) is a multifactorial disease of the ocular surface accompanied by neurosensory abnormalities. Here, we evaluated the...
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Expression of ASIC3 in the Trigeminal Nucleus Caudalis Plays a Role in a Rat Model of Recurrent Migraine
Acid-sensing ion channel 3 (ASIC3) is abundant in the trigeminal nervous system and is most sensitive to a slight pH decrease. Recent studies have...
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Visceral Nociception in Gastrointestinal Disease
Abdominal pain is common across organic and functional gastrointestinal disorders. For example, most patients with inflammatory bowel disease (IBD)...
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Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors
With swee** advances in precision delivery systems and manipulation of the genomes and transcriptomes of various cell types, medical biotechnology...
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Peripheral Mechanism of Cancer-Induced Bone Pain
Cancer-induced bone pain (CIBP) is a type of ongoing or breakthrough pain caused by a primary bone tumor or bone metastasis. CIBP constitutes a...
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Mirror-Image Pain Update: Complex Interactions Between Central and Peripheral Mechanisms
The appearance of contralateral effects after unilateral injury has been shown in various experimental pain models, as well as in clinics. They...
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The role of acid-sensing ion channels in monosodium urate-induced gouty pain in mice
Acid-sensing ion channels (ASICs) in dorsal root ganglion (DRG) neurons play an important role in inflammatory pain. The objective of this study is...
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Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness
We reviewed fundamental studies on muscular pain, encompassing the characteristics of primary afferent fibers and neurons, spinal and thalamic...
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Is the Sex Difference a Clue to the Pathomechanism of Dry Eye Disease? Watch out for the NGF-TrkA-Piezo2 Signaling Axis and the Piezo2 Channelopathy
Dry eye disease (DED) is a multifactorial disorder with recognized pathology, but not entirely known pathomechanism. It is suggested to represent a...
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Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase–Independent Acid Sensing of Mouse Olfactory Sensory Neurons
Acids can disturb the ecosystem of wild animals through altering their olfaction and olfaction-related survival behaviors. It is known that the main...
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Endothelin-1 enhances acid-sensing ion channel currents in rat primary sensory neurons
Endothelin-1 (ET-1), an endogenous vasoactive peptide, has been found to play an important role in peripheral pain signaling. Acid-sensing ion...
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Targeting memory loss with aspirin, a molecular mechanism perspective for future therapeutic approaches
Acetylsalicylic acid (ASA), also known as aspirin, was discovered in 1897 as an acetylated form of salicylate. It has been widely used for its...
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Ion Channel Tools and Therapeutics from Venoms and Toxins
For almost as long as the ion channels in our brains have powered conscious thought, we have been fascinated by venoms and toxins. Initially thought...