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APE1 promotes non-homologous end joining by initiating DNA double-strand break formation and decreasing ubiquitination of artemis following oxidative genotoxic stress
BackgroundApurinic/apyrimidinic endonuclease 1 (APE1) imparts radio-resistance by repairing isolated lesions via the base excision repair (BER)...
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APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett’s-associated esophageal adenocarcinomas
BackgroundEsophageal adenocarcinoma (EAC) is characterized by poor prognosis and low survival rate. Chronic gastroesophageal reflux disease (GERD) is...
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Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT
BackgroundMetastasis is a major challenge in cervical cancer treatment. Previous studies have shown that the dual functional protein...
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APE1 may influence CD4+ naïve T cells on recurrence free survival in early stage NSCLC
BackgroundIt was demonstrated that multifunctional protein APE1 (Apurinic/apyrimidinic endonuclease 1) is closely related to tumor immune...
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Proteomics reveals a therapeutic vulnerability via the combined blockade of APE1 and autophagy in lung cancer A549 cells
BackgroundDrug resistance is a major cause of therapeutic failure that is often associated with elevated autophagy and apurinic/apyrimidinic...
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Selective anti-tumor activity of glutathione-responsive abasic site trap** agent in anaplastic thyroid carcinoma
Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive thyroid cancer with poor prognosis. Killing cancer cells by inducing DNA damage or...
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The Long-Term Impact of Ionizing Radiation on DNA Damage in Patients Undergoing Multiple Cardiac Catheterizations
Ionizing radiation (IR) exposures have increased exponentially in recent years due to the rise in diagnostic and therapeutic interventions. A number...
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Methods to Assess Oxidative DNA Base Damage Repair of Apurinic/Apyrimidinic (AP) Sites Using Radioactive and Nonradioactive Oligonucleotide-Based Assays
Reactive oxygen species (ROS) overproduction results in oxidative stress leading to genomic instability via the generation of small base lesions in...
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Cell Cycle, DNA Damage Repair Systems, and Impact of Redox Regulation in Cancer
This chapter entitled “Cell Cycle, DNA Damage Repair Systems, and Impact of Redox Regulation in Cancer” introduces the cell cycle components in...
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APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC
BackgroundTriple negative breast cancer (TNBC) is a breast cancer subgroup characterized by a lack of hormone receptors’ expression and no HER2...
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Oxidized DNA Base Damage Repair and Transcription
The DNA bases in the genome are susceptible to oxidation by reactive oxygen species (ROS). The oxidized DNA base lesions such as 8-oxoguanine...
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Mitochondrial apurinic/apyrimidinic endonuclease 1 enhances mtDNA repair contributing to cell proliferation and mitochondrial integrity in early stages of hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is the leading cause of primary liver cancers. Surveillance of individuals at specific risk of develo**...
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Bioassay-Guided extraction of andrographis paniculata for intervention of in-vitro prostate cancer progression in metabolic syndrome environment
BackgroundMetabolic syndrome (MetS) is a risk factor for prostate cancer (PCa) progression. Thus, this life-threatening disease demands a proactive...
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ROS, Redox Regulation, and Anticancer Therapy
This chapter entitled “ROS, Redox Regulation, and Anticancer Therapy” includes all redox-regulated cancer therapy events. Here in this chapter...
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Oxidized DNA Base Damage Repair and Transcription
The DNA bases in the genome are susceptible to oxidation by reactive oxygen species (ROS). The oxidized DNA base lesions such as 8-oxoguanine...
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Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers
The MRE11–RAD50–NBS1 (MRN) complex is critical for genomic stability. Although germline mutations in MRN may increase breast cancer susceptibility,...
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Spatially resolved in vivo imaging of inflammation-associated mRNA via enzymatic fluorescence amplification in a molecular beacon
The in vivo optical imaging of RNA biomarkers of inflammation is hindered by low signal-to-background ratios, owing to non-specific signal...
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8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification
In pathophysiology, reactive oxygen species control diverse cellular phenotypes by oxidizing biomolecules. Among these, the guanine base in nucleic...
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Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Redox homeostasis refers to the balance between the production of reactive oxygen species (ROS) as well as reactive nitrogen species (RNS), and their...
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Circle Damage Sequencing for Whole-Genome Analysis of DNA Damage
There are many sources of endogenous and exogenous DNA damage. Damaged bases represent a threat to genome integrity and may interfere with normal...