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P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways
It has been demonstrated that the ATP-gated ion channel P2X7 receptor is involved in tumor progression and plays an important role in regulating...
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Comparing the toxicity effects of copper oxide nanoparticles conjugated with Lapatinib on breast (MDA-MB-231) and lung (A549) cancer cell lines
In recent years, the increase in cancer morbidity and mortality has presented scientists with a major challenge in develo** new therapeutic agents...
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Biological evaluation of levofloxacin and its thionated derivatives: antioxidant activity, aldehyde dehydrogenase enzyme inhibition, and cytotoxicity on A549 cell line
Levofloxacin (LVX) is among the fluoroquinolones antibiotics that has also been studied in vitro and in vivo for its anticancer effects. In this...
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Effect of Glucose Starvation on Cell Viability Parameters in A549 and BEAS-2B Cell Lines
AbstractCancer cells are metabolically altered cells characterized by higher glucose uptake. Understanding cancer cells is vital in cancer therapy....
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Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)
A new chalcone series has been developed that may be useful in the treatment of lung cancer. The new series was confirmed by the different spectral...
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Investigating the role of let-7a microRNA in cisplatin sensitivity of A549 lung cancer cells
Lung cancer (LC) is a major cause of death worldwide, and cisplatin is commonly used as a chemotherapeutic drug for the treatment of LC. However,...
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Isovincathicine from Catharanthus roseus induces apoptosis in A549 cells
A dimeric indole alkaloid, isovincathicine consisting of an aspidosperma type and modified iboga with C-7–C-20 connection type skeletons was first...
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Synergistic Effects of Taurine and Cisplatin on Lung Cancer Cells (A549)
AbstractLung cancer is one of the most common types of cancer that causes death. In this study, the effects of cisplatin, taurine, and a combination...
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TRIM21 reduces H1N1-induced inflammation and apoptosis by regulating the TBK1–IRF3 signaling pathway in A549 cells
Triple motif protein 21 (TRIM21) has an antiviral function that inhibits various viral infections. However, its role in the progress of influenza A...
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Antitumor activity and mechanism of cucurbitacin B in A549/DDP cells
Cucurbitacin B (CuB) is a class of tetracyclic triterpenoids isolated from Cucurbitaceae with a wide range of anti-inflammatory and anti-tumor...
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Modular air–liquid interface aerosol exposure system (MALIES) to study toxicity of nanoparticle aerosols in 3D-cultured A549 cells in vitro
We present a novel lung aerosol exposure system named MALIES (modular air–liquid interface exposure system), which allows three-dimensional...
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Daidzein nanosuspension in combination with cisplatin to enhance therapeutic efficacy against A549 non-small lung cancer cells: an in vitro evaluation
Lung cancer is the most common cause of cancer-related mortality, chemo-resistance, and toxicity limit treatment. The focus is on innovative combined...
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Effect of isolated grandivittin from Ferulago trifida Boiss. (Apiaceae) on the proliferation and apoptosis of human lung cancer A549 cells
Lung cancer is one of the deadliest cancers in the world. Introducing new promising agents can help the chemotherapeutic management of cancer. In the...
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Culture of Continuous Cell Lines
This chapter describes the culture of various continuous cell lines. Continuous cell lines are generated either due to specific genetic or epigenetic...
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The regulation of TRPA1 expression and function by Th1 and Th2-type inflammation in human A549 lung epithelial cells
BackgroundTransient Receptor Potential Ankyrin 1 (TRPA1) is a cation channel that mediates pain, itch, cough, and neurogenic inflammation in response...
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Engineered Nanoscale Lipid-Based Formulation as Potential Enhancer of Gefitinib Lymphatic Delivery: Cytotoxicity and Apoptotic Studies Against the A549 Cell Line
The present study aimed to engineer a nanoscale lipid-based lymphatic drug delivery system with D-α-Tocopherol polyethylene glycol 1000 succinate to...
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Role of integrin α2 in methotrexate-induced epithelial-mesenchymal transition in alveolar epithelial A549 cells
Methotrexate (MTX) is widely used to treat various diseases. However, it induces adverse reactions like serious lung injury, including pulmonary...
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Anti-inflammatory effects of Athyrium yokoscense extract via inhibition of the Erk1/2 and NF-κB pathways in bisphenol A-stimulated A549 cells
Bisphenol A is an environmental endocrine disruptor that has similar functions to estrogen in humans. However, few studies have investigated...
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Swine influenza virus triggers ferroptosis in A549 cells to enhance virus replication
BackgroundRecently, Influenza A virus (IAV) has been shown to activate several programmed cell death pathways that play essential roles in host...
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Ovarian cancer G protein-coupled receptor 1 inhibits A549 cells migration through casein kinase 2α intronless gene and neutral endopeptidase
BackgroundWe have previously reported that a new intronless gene for casein kinase 2α (CK2α), CSNK2A3, is expressed in human cells. The promoter of...
