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Therapeutic Targeting of Potassium Channels
Potassium (K+) channels are the largest group of ion channels in mammals. The immediate function of these channels is electrogenic transport of K+...
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Aminophylline at clinically relevant concentrations affects inward rectifier potassium current in a dual way
Bronchodilator aminophylline may induce atrial or less often ventricular arrhythmias. The mechanism of this proarrhythmic side effect has not been...
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Single Neuron Modeling Identifies Potassium Channel Modulation as Potential Target for Repetitive Head Impacts
Traumatic brain injury (TBI) and repetitive head impacts can result in a wide range of neurological symptoms. Despite being the most common...
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Lysosomal Potassium Channels
Lysosomes are acidic membrane-bound organelles that use hydrolytic enzymes to break down material through pathways such as endocytosis, phagocytosis,...
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Dissolution profile evaluation of selected brands of amoxicillin-clavulanate potassium 625 mg tablets retailed in Hawassa town, Sidama Regional State, Ethiopia
Poor quality amoxicillin-clavulanate potassium tablets have been recently discovered in generic drugs related to Augmentin-like medicines containing...
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Potential Benefit of Channel Activators in Loss-of-Function Primary Potassium Channelopathies Causing Heredoataxia
Potassium channels (KCN) are transmembrane complexes that regulate the resting membrane potential and the duration of action potentials in cells. The...
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Extracellular histones promote TWIK2-dependent potassium efflux and associated NLRP3 activation in alveolar macrophages during sepsis-induced lung injury
Background and aimSepsis-induced acute lung injury (ALI) is a complex and life-threatening condition lacking specific and efficient clinical...
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Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating ATP-sensitive potassium channels
Dopaminergic neurons in the substantia nigra (SN) expressing SUR1/Kir6.2 type ATP-sensitive potassium channels (K-ATP) are more vulnerable to...
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Single-compartment model of a pyramidal neuron, fitted to recordings with current and conductance injection
For single neuron models, reproducing characteristics of neuronal activity such as the firing rate, amplitude of spikes, and threshold potentials as...
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Loss of the large conductance calcium-activated potassium channel causes an increase in mitochondrial reactive oxygen species in glioblastoma cells
Mitochondrial potassium (mitoK) channels play an important role in cellular physiology. These channels are expressed in healthy tissues and cancer...
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Quercetin flavonoid and vitamin C recuperate kidney functions in potassium bromate-induced renal dysfunction in Wistar rats
Studies into the functions and mechanisms of action of quercetin may be able to help dispel the negative effects of toxicants on renal toxicity due...
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Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition
Channelrhodopsins are used widely for optical control of neurons, in which they generate photoinduced proton, sodium or chloride influx. Potassium (K + ...
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Lidocaine pretreatment attenuates inflammatory response and protects against sepsis-induced acute lung injury via inhibiting potassium efflux-dependent NLRP3 activation
ObjectiveSepsis may often result in acute lung injury (ALI), with a high mortality and morbidity. Available evidence indicates that activation of...
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Potassium Channels in Cancer
Neoplastic transformation is reportedly associated with alterations of the potassium transport across plasma and intracellular membranes. These...
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Pharmacological Approaches to Studying Potassium Channels
In this review, we consider the pharmacology of potassium channels from the perspective of these channels as therapeutic targets. Firstly, we...
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A general pattern of non-spiking neuron dynamics under the effect of potassium and calcium channel modifications
Electrical activity of excitable cells results from ion exchanges through cell membranes, so that genetic or epigenetic changes in genes encoding ion...
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Co-crystallization of Amoxicillin Trihydrate and Potassium Clavulanate Provides a Promising Approach for Preparation of Sustained-Release Microspheres
This work aimed to prepare sustained-release microspheres for amoxicillin trihydrate and potassium clavulanate. Co-crystals of amoxicillin trihydrate...
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Potassium homeostasis: sensors, mediators, and targets
Transmembrane potassium (K) gradients are key determinants of membrane potential that can modulate action potentials, control muscle contractility,...
