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Metabolic plasticity imparts erlotinib-resistance in pancreatic cancer by upregulating glucose-6-phosphate dehydrogenase
Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant forms of cancer. Lack of effective treatment options and drug resistance...
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Repurposing an Antiepileptic Drug for the Treatment of Glioblastoma
PurposeGlioblastoma multiforme (GBM) is a grade IV, highly proliferative, and malignant form of brain tumor with a 5-year survival rate at ~ 5%....
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The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration
BackgroundMetabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a...
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Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells during JEV Infection
Japanese encephalitis virus (JEV) is a leading cause of viral encephalitis in endemic regions of Asia. The neurotropism of JEV and its...
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Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway
BackgroundThe aberrant formation of neutrophil extracellular traps (NETs) has been implicated in ulcerative colitis (UC), a chronic recurrent...
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A feedback loop of PPP and PI3K/AKT signal pathway drives regorafenib-resistance in HCC
BackgroundHepatocellular carcinoma (HCC) is a principal type of liver cancer with high incidence and mortality rates. Regorafenib is a novel oral...
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Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions
BackgroundSeveral studies have described a potential anti-tumour effect of cannabinoids (CNB). CNB receptor 2 (CB2) is mostly present in...
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Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity
BackgroundChaperon-mediated autophagy (CMA) has taken on a new emphasis in cancer biology. However, the roles of CMA in hypoxic tumours are poorly...
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Deciphering cellular plasticity in pancreatic cancer for effective treatments
Cellular plasticity and therapy resistance are critical features of pancreatic cancer, a highly aggressive and fatal disease. The pancreas, a vital...
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G6PDi-1 is a Potent Inhibitor of G6PDH and of Pentose Phosphate pathway-dependent Metabolic Processes in Cultured Primary Astrocytes
Glucose-6-phosphate dehydrogenase (G6PDH) catalyses the rate limiting first step of the oxidative part of the pentose phosphate pathway (PPP), which...
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Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy
Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past, elesclomol was recognized as an inducer of oxidative stress, but...
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Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
Inflammatory bowel disease (IBD) is prevalent, and no satisfactory therapeutic options are available because the mechanisms underlying its...
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Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe?
The nicotinamide adenine dinucleotide (NAD + /NADH) and nicotinamide adenine dinucleotide phosphate (NADP + /NADPH) redox couples function as cofactors...
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Photodynamic Oxidative Stress Targets Cancer as Well as Cancer Stem Cells
Cancer cells contain more reactive oxygen species (ROS) than normal cells; therefore, ROS is closely related to tumorigenesis. While cancer cells...
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Insulin-induced gene 2 protects against hepatic ischemia–reperfusion injury via metabolic remodeling
BackgroundHepatic ischemia–reperfusion (IR) injury is the primary reason for complications following hepatectomy and liver transplantation (LT)....
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Photodynamic Oxidative Stress Targets Cancer as Well as Cancer Stem Cells
Cancer cells contain more reactive oxygen species (ROS) than normal cells; therefore, ROS is closely related to tumorigenesis. While cancer cells...
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Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions
Cell death is an important part of the life cycle, serving as a foundation for both the orderly development and the maintenance of physiological...
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Changes in Kolmer Cells in SHR Rats after Cerebral Ischemia
Kolmer cells (epiplexus macrophages) constitute the least studied population among the phagocytosing cells in the mammalian brain. We report here...