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Investigating the TLR4/TAK1/IRF7 axis in NLRP3-Mediated Pyroptosis in Parkinson's Disease
In the realm of Parkinson's disease (PD) research, NLRP3 inflammasome-mediated pyroptosis has recently garnered significant attention as a potential...
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TAK1-inhibitors did not reduce disease burden in a Vκ*MYC model of multiple myeloma
ObjectiveMultiple myeloma is a haematological malignancy characterized by proliferation of monoclonal plasma cells in the bone marrow. Development of...
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Blocking reverse electron transfer-mediated mitochondrial DNA oxidation rescues cells from PANoptosis
PANoptosis is a new type of cell death featured with pyroptosis, apoptosis and necroptosis, and is implicated in organ injury and mortality in...
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Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke
AbstractTransforming growth factor-β-activated kinase 1 (TAK1) is upregulated after cerebral ischemia and contributes to an aggravation of brain...
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A Streamlined Method for Detecting Inflammasome-Induced ASC Oligomerization Using Chemical Crosslinking
The apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC) functions as the integral adaptor protein...
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cFLIPS regulates alternative NLRP3 inflammasome activation in human monocytes
The innate immune responses, including inflammasome activation, are paramount for host defense against pathogen infection. In contrast to canonical...
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Influenza A virus infection disrupts oligodendrocyte homeostasis and alters the myelin lipidome in the adult mouse
BackgroundRecent data suggest that myelin may be altered by physiological events occurring outside of the central nervous system, which may cause...
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TAK1 mediates neuronal pyroptosis in early brain injury after subarachnoid hemorrhage
BackgroundInnate immunity can facilitate early brain injury (EBI) following subarachnoid hemorrhage (SAH). Numerous studies suggest that pyroptosis...
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TGF-β Activated Kinase 1 (TAK1) Is Activated in Microglia After Experimental Epilepsy and Contributes to Epileptogenesis
Increasing evidence suggests that inflammation promotes epileptogenesis. TAK1 is a central enzyme in the upstream pathway of NF-κB and is known to...
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TAK1 signaling is a potential therapeutic target for pathological angiogenesis
Angiogenesis plays a critical role in both physiological responses and disease pathogenesis. Excessive angiogenesis can promote neoplastic diseases...
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Microglia in retinal angiogenesis and diabetic retinopathy
Diabetic retinopathy has a high probability of causing visual impairment or blindness throughout the disease progression and is characterized by the...
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Erythropoietin Abrogates Post-Ischemic Activation of the NLRP3, NLRC4, and AIM2 Inflammasomes in Microglia/Macrophages in a TAK1-Dependent Manner
Inflammasomes are known to contribute to brain damage after acute ischemic stroke (AIS). TAK1 is predominantly expressed in microglial cells and can...
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Identification of a novel m6A-related lncRNAs signature and immunotherapeutic drug sensitivity in pancreatic adenocarcinoma
BackgroundPancreatic adenocarcinoma (PDAC) ranks as the fourth leading cause for cancer-related deaths worldwide. N6-methyladenosine (m6A) and long...
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Small-molecule discovery through DNA-encoded libraries
The development of bioactive small molecules as probes or drug candidates requires discovery platforms that enable access to chemical diversity and...
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Inhibition of LPS-mediated TLR4 activation abrogates gastric adenocarcinoma-associated peritoneal metastasis
AbstractSurgical resection, the cornerstone of curative intent treatment for gastric adenocarcinoma, is associated with a high rate of...
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Identification of TLN1 as a prognostic biomarker to effect cell proliferation and differentiation in acute myeloid leukemia
The protein Talin1 encoded by the TLN1 gene is a focal adhesion-related protein that binds to various cytoskeletal proteins and plays an important...
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Promotion of microtubule acetylation plays an important role in degranulation of antigen-activated mast cells
ObjectiveThe aim of this study was to investigate whether microtubule acetylation is triggered by antigen stimulation and how it affects mast cell...
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Suppression of monosodium urate crystal-induced inflammation by inhibiting TGF-β-activated kinase 1-dependent signaling: role of the ubiquitin proteasome system
Monosodium urate (MSU) crystals activate inflammatory pathways that overlap with interleukin-1β (IL-1β) signaling. However, the post-translational...
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Functions of MAP3Ks in antiviral immunity
Immune signal transduction is crucial to the body’s defense against viral infection. Recognition of pathogen-associated molecular patterns by pattern...
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Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in A549 cells
KRAS mutant lung cancers have long been considered as untreatable with drugs. Transforming growth factor-β-activated kinase 1 (TAK1) appears to play...
