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An Investigation into the Relationship of Circulating Gut Microbiome Molecules and Inflammatory Markers with the Risk of Incident Dementia in Later Life
The gut microbiome may be involved in the occurrence of dementia primarily through the molecular mechanisms of producing bioactive molecules and...
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Cerebrospinal fluid levels of 5-HIAA and dopamine in people with HIV and depression
Depression is a common illness in people with HIV (PWH) and is associated with substantial morbidity and mortality. The mechanisms that underpin...
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Systemic perturbations in amino acids/amino acid derivatives and tryptophan pathway metabolites associated with murine influenza A virus infection
BackgroundInfluenza A virus (IAV) is the only influenza virus causing flu pandemics (i.e., global epidemics of flu disease). Influenza (the flu) is a...
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Sexually dimorphic effects of prenatal diazepam exposure on respiratory control and the monoaminergic system of neonate and young rats
Pregnancy is highly affected by anxiety disorders, which may be treated with benzodiazepines, especially diazepam (DZP), that can cross the placental...
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Serum Aromatic Microbial Metabolites as Biological Markers in Intensive Care
Thanks to modern technical solutions and advances in the field of metabolomic research, it has become possible to search for new biomarkers among...
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Supplementation with high-GABA-producing Lactobacillus plantarum L5 ameliorates essential tremor triggered by decreased gut bacteria-derived GABA
BackgroundThe γ-aminobutyric acid (GABA) hypothesis posits a role of GABA deficiency in the central nervous system in the pathogenesis and...
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Biomarkers of intake for tropical fruits
Consumption of fruit and vegetable is a key component of a healthy and sustainable diet. However, their accurate dietary assessment remains a...
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Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the “Lunar Palace 365” experiment
BackgroundPsychological health risk is one of the most severe and complex risks in manned deep-space exploration and long-term closed environments....
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Serum Aromatic Microbial Metabolites as Biological Markers in Intensive Care
Thanks to modern technical solutions and advances in the field of metabolomic research, it has become possible to search for new biomarkers among...
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Exploring pharmacokinetics and herb-drug interactions of an herbal extract mixture derived from Poria cocos and Morus alba L.
PurposePoria cocos and Morus alba L., recognized as traditional Chinese medicines (TCMs), have gained attention for their diverse pharmacological...
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Chronic kidney disease may evoke anxiety by altering CRH expression in the amygdala and tryptophan metabolism in rats
Chronic kidney disease (CKD) is associated with anxiety; however, its exact mechanism is not well understood. Therefore, the aim of the present study...
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Oral administration of TiO2 nanoparticles during early life impacts cardiac and neurobehavioral performance and metabolite profile in an age- and sex-related manner
BackgroundNanoparticles (NPs) are increasingly incorporated in everyday products. To investigate the effects of early life exposure to orally...
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Immune regulation through tryptophan metabolism
Amino acids are fundamental units of molecular components that are essential for sustaining life; however, their metabolism is closely interconnected...
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Amino Acids in Microbial Metabolism and Function
Amino acidsAmino acids (AAs) not only serve as building blocks for protein synthesis in microorganisms but also play important roles in their...
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Nutrition and Brain Neurotransmitters
Neurotransmitters are the chemical language with which different neurons communicate and with which the brain and the environment communicate with...
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Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota
AbstractGut microbiota in interaction with intestinal host tissues influences many brain functions and microbial dysbiosis has been linked with brain...
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The effect of a novel anticonvulsant chemical Q808 on gut microbiota and hippocampus neurotransmitters in pentylenetetrazole-induced seizures in rats
BackgroundThe gut microbiota can modulate brain function and behavior and is increasingly recognized as an important factor in mediating the risk of...
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Metabolomics analysis of visceral leishmaniasis based on urine of golden hamsters
BackgroundLeishmaniasis is one of the most neglected tropical diseases and is spread mainly in impoverished regions of the world. Although many...
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TRPV1 inhibition suppresses non-small cell lung cancer progression by inhibiting tumour growth and enhancing the immune response
PurposeTRPV1 is a nonselective Ca 2+ channel protein that is widely expressed and plays an important role during the occurrence and development of...
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Connections Between Micronutrients, Cerebral Monoamines and Related Brain Disorders
Micronutrients provide the building units, precursors, vitamins, and the enzymatic cofactors required for correct biosynthesis of neurotransmitters,...