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Lung macrophages are involved in lung injury secondary to repetitive diving
This study aimed to establish an animal model of decompression-induced lung injury (DILI) secondary to repetitive diving in mice and explore the role...
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RGFP966 inactivation of the YAP pathway attenuates cardiac dysfunction induced by prolonged hypothermic preservation
Oxidative stress and apoptosis are the key factors that limit the hypothermic preservation time of donor hearts to within 4–6 h. The aim of this...
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Protective effects of methane-rich saline on mice with allergic asthma by inhibiting inflammatory response, oxidative stress and apoptosis
BackgroundAsthma is a common cause of breathing difficulty in children and adults, and is characterized by chronic airway inflammation that is poorly...
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An oriental melon 9-lipoxygenase gene CmLOX09 response to stresses, hormones, and signal substances
In plants, lipoxygenases (LOXs) play a crucial role in biotic and abiotic stresses. In our previous study, five 13-LOX genes of oriental melon were...
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Catalpol ameliorates LPS-induced endometritis by inhibiting inflammation and TLR4/NF-κB signaling
Catalpol is the main active ingredient of an extract from Radix rehmanniae , which in a previous study showed a protective effect against various...
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Proteomic analysis of human umbilical vein endothelial cells exposed to PM2.5
Exposure to fine ambient particulate matter (PM 2.5 ) is known to be associated with cardiovascular disease. To uncover the molecular mechanisms...
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NF-κB in mitochondria regulates PC12 cell apoptosis following lipopolysaccharide-induced injury
ObjectiveTo determine the relationship between nuclear transcription factor κB (NF-κB) expression in mitochondria and neuronal cell apoptosis after...
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Excitotoxicity effects of glutamate on human neuroblastoma SH-SY5Y cells via oxidative damage
ObjectiveTo investigate the mechanisms of excitotoxic effects of glutamate on human neuroblastoma SH-SY5Y cells.
MethodsSH-SY5Y cell viability was...
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1-Methyl-4-phenyl-pyridinium time-dependently alters expressions of oxoguanine glycosylase 1 and xeroderma pigmentosum group F protein in PC12 cells
ObjectiveTo determine if DNA excision repair enzymes oxoguanine glycosylase 1 (OGG1) and xeroderma pigmentosum group F protein (XPF) are involved in...
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The mechanisms of brain ischemic insult and potential protective interventions
The mechanisms of brain ischemic insult include glutamate excitoxicity, calcium toxicity, free radicals, nitric oxide, inflammatory reactions, as...
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RETRACTED ARTICLE: Pro-protein convertase-2/carboxypeptidase-E mediated neuropeptide processing of RGC-5 cell after in vitro ischemia
ObjectiveTo observe the change of the neuropeptide pro-protein processing system in the ischemic retina ganglion cell-5 (RGC-5) cells, pro-protein...
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Minocycline attenuates cognitive impairment and restrains oxidative stress in the hippocampus of rats with chronic cerebral hypoperfusion
ObjectiveNitric oxide (NO) was speculated to play an important role in the pathophysiology of cerebral ischemia. Minocycline, a tetracycline...
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Iron contributes to the formation of catechol isoquinolines and oxidative toxicity induced by overdose dopamine in dopaminergic SH-SY5Y cells
ObjectiveThe selective loss of dopaminergic neurons in Parkinson’s disease is suspected to correlate with the increase of cellular iron, which may be...