Search
Search Results
-
Aeromonas sobria regulates proinflammatory immune response in mouse macrophages via activating the MAPK, AKT, and NF-κB pathways
目的以利用小鼠原代腹腔巨噬细胞建立了一种温和气单胞菌体外感染模型, 探究MAPK、 AKT和NF-κB信号通路在温和气单胞菌诱导宿主细胞炎性应答中的作用及相关的分子机制, 为防治温和气单胞菌造成的感染提供新的治疗靶点.
创新点首次探究了丝裂原活化蛋白激酶(mitogen-activated...
-
Effect of resveratrol treatment on apoptosis and apoptotic pathways during boar semen freezing
Resveratrol (3,5,4'-trihydroxystilbene, RSV) has been widely used in mammalian cells, but whether it can be used during freezing boar semen is still...
-
Effects of nanofibers on mesenchymal stem cells: environmental factors affecting cell adhesion and osteogenic differentiation and their mechanisms
Nanofibers can mimic natural tissue structure by creating a more suitable environment for cells to grow, prompting a wide application of nanofiber...
-
Lung macrophages are involved in lung injury secondary to repetitive diving
This study aimed to establish an animal model of decompression-induced lung injury (DILI) secondary to repetitive diving in mice and explore the role...
-
Microencapsulation of immunoglobulin Y: optimization with response surface morphology and controlled release during simulated gastrointestinal digestion
Immunoglobulin Y (IgY) is an effective orally administered antibody used to protect against various intestinal pathogens, but which cannot tolerate...
-
Regulatory mechanisms and therapeutic potential of microglial inhibitors in neuropathic pain and morphine tolerance
Microglia are important cells involved in the regulation of neuropathic pain (NPP) and morphine tolerance. Information on their plasticity and...
-
Drying temperature affects rice seed vigor via gibberellin, abscisic acid, and antioxidant enzyme metabolism
Seed vigor is a key factor affecting seed quality. The mechanical drying process exerts a significant influence on rice seed vigor. The initial...
-
Activation of anthrachamycin biosynthesis in Streptomyces chattanoogensis L10 by site-directed mutagenesis of rpoB
Genome sequencing projects revealed massive cryptic gene clusters encoding the undiscovered secondary metabolites in Streptomyces. To investigate the...
-
Hydrogen agronomy: research progress and prospects
Agriculture is the foundation of social development. Under the pressure of population growth, natural disasters, environmental pollution, climate...
-
Development and optimization of an intergeneric conjugation system and analysis of promoter activity in Streptomyces rimosus M527
An efficient genetic transformation system and suitable promoters are essential prerequisites for gene expression studies and genetic engineering in...
-
Novel ACADVL variants resulting in mitochondrial defects in long-chain acyl-CoA dehydrogenase deficiency
The pathogenesis of very-long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is highly heterogeneous and still unclear. Additional novel variants...
-
Amyloid precursor protein regulates 5-fluorouracil resistance in human hepatocellular carcinoma cells by inhibiting the mitochondrial apoptotic pathway
Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality globally. It accounts for the majority of primary liver cancer...
-
Verticillin A inhibits colon cancer cell migration and invasion by targeting c-Met
Verticillin A is a diketopiperazine compound which was previously isolated from Amanita flavorubescens Alk (containing parasitic fungi Hypomyces...
-
Effects of calcium-binding sites in the S2–S3 loop on human and Nematostella vectensis TRPM2 channel gating processes
As a crucial signaling molecule, calcium plays a critical role in many physiological and pathological processes by regulating ion channel activity....
-
Apical ectodermal ridge regulates three principal axes of the develo** limb
Understanding limb development not only gives insights into the outgrowth and differentiation of the limb, but also has clinical relevance. Limb...
-
Gene editing: an instrument for practical application of gene biology to plant breeding
Plant breeding is well recognized as one of the most important means to meet food security challenges caused by the ever-increasing world population....
-
Toxicity and metabolism of 3-bromopyruvate in Caenorhabditis elegans
In this study, we aimed to evaluate the toxic effects, changes in life span, and expression of various metabolism-related genes in Caenorhabditis...