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Protein Misfolding Cyclic Amplification
Prion diseases are caused by a conformational conversion of the cellular prion protein (PrPC) to a pathological conformer (PrPSc). The “prion-only”...
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Detection of monkeypox virus using helicase dependent amplification and recombinase polymerase amplification combined with lateral flow test
The monkeypox virus (MPXV) is a zoonotic DNA virus that belongs to the poxvirus family. Conventional laboratory methods for detecting MPXV are...
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Antigen Retrieval and Signal Amplification
Immunohistochemistry (IHC) offers a valuable method for determining the spatial distribution of proteins in cells and tissues. Fixation of tissues...
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A skin-specific α-Synuclein seeding amplification assay for diagnosing Parkinson’s disease
The seeding amplification assay (SAA) has recently emerged as a valuable tool for detecting α-synuclein (αSyn) aggregates in various clinically...
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PMS2 amplification contributes brain metastasis from lung cancer
BackgroundLung adenocarcinoma metastasizing to the brain results in a notable increase in patient mortality. The high incidence and its impact on...
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Real-time recombinase-aided amplification assay for rapid amplification of the IS1081 gene of Mycobacterium tuberculosis
Mycobacterium tuberculosis (MTB), the etiological agent of tuberculosis (TB), is the leading cause of death due to a single infectious agent...
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Rapid identification of SARS-CoV-2 strains via isothermal enzymatic recombinase amplification and nanopore sequencing
Surveillance of the SARS-CoV-2 genome has become a crucial technique in the management of COVID-19, aiding the pandemic response and supporting...
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Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein
Cell-to-cell transmission and subsequent amplification of pathological proteins promote neurodegenerative disease progression. Most research on this...
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Outcomes of patients with multiple myeloma and 1q gain/amplification receiving autologous hematopoietic stem cell transplant: the MD Anderson cancer center experience
The prognostic impact of additional copies of chromosome 1q (1q + ) on outcomes of newly-diagnosed multiple myeloma (NDMM) patients undergoing...
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Rapid detection of human adenovirus subgroup B using recombinase polymerase amplification assay
Human adenovirus subgroup B (HAdV B) is one of the major pathogens of human respiratory virus infections, which has considerable transmission and...
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Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance
BackgroundAlthough DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes...
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Rapid and sensitive visual detection of avian leukosis virus by reverse transcription loop-mediated isothermal amplification combined with a lateral flow immunochromatographic strip assay
Considering that avian leukosis virus (ALV) infection has inflicted massive economic losses on the poultry breeding industry in most countries, its...
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Efficient detection of Streptococcus pyogenes based on recombinase polymerase amplification and lateral flow strip
PurposeThis article aims to establish a rapid visual method for the detection of Streptococcus pyogenes (GAS) based on recombinase polymerase...
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ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells
BackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer and the chemotherapies such as gemcitabine/nab-paclitaxel...
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The effect of greater occipital nerve block on amplification of somatic symptoms and anxiety and depression levels in chronic migraine
ObjectivesIt is known that chronic migraine (CM) is often accompanied by anxiety, depression, and psychosomatic complaints. We designed this study...
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HER2 amplification level by in situ hybridization predicts survival outcome in advanced HER2-positive breast cancer treated with pertuzumab, trastuzumab, and docetaxel regardless of HER2 IHC results
BackgroundThe role of HER2 amplification level in predicting the effectiveness of HER2-directed therapies has been established. However, its...
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SIX1 amplification modulates stemness and tumorigenesis in breast cancer
BackgroundSine oculis homeobox homolog 1 (SIX1) is a transcription factor that has recently been identified as a crucial regulator of embryonic...
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Copy number signatures and CCNE1 amplification reveal the involvement of replication stress in high-grade endometrial tumors oncogenesis
PurposeManaging high-grade endometrial cancer in Martinique poses significant challenges. The diversity of copy number alterations in high-grade...
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Reverse transcription recombinase-aided amplification assay for avian influenza virus
Avian influenza virus (AIV) infection can lead to severe economic losses in the poultry industry and causes a serious risk for humans. A rapid and...
