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Patch-Clamp Recordings from Human Embryonic Stem Cells-Derived Fragile X Neurons
Performing electrophysiological recordings from human neurons that have been differentiated in vitro, as compared to primary cultures, raises many...
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Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients
BackgroundMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystemic condition associated with post-infectious onset,...
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Duloxetine HCl Alleviates Asthma Symptoms by Regulating PI3K/AKT/mTOR and Nrf2/HO-1 Signaling Pathways
Asthma is an inflammatory disease characterized by airway hyperresponsiveness, airway remodeling, and airway inflammation. In recent years, the...
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Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C γ Translocation in Cerebellar Purkinje Cells
The cerebellum contains the highest density of protein kinase C (PKC) in the central nervous system. PKCγ, the major isotype accounting for over half...
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Map** Synaptic Connectivity in the Cerebellar Cortex Using RuBi-Glutamate Uncaging
Synaptic functional organization of excitatory and inhibitory inputs in neuronal microcircuits organizes dynamics and underlies learning processes....
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Inhibitory effects on L- and N-type calcium channels by a novel CaVβ1 variant identified in a patient with autism spectrum disorder
Voltage-gated calcium channel (VGCC) subunits have been genetically associated with autism spectrum disorders (ASD). The properties of the...
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Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes
Paracrine ATP release by erythrocytes has been shown to regulate endothelial cell function via purinergic signaling, and this erythoid-endothelial...
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Bilirubin potentiates etomidate-induced sedation by enhancing GABA-induced currents after bile duct ligation
ObjectivesOur previous clinical trial showed that etomidate requirements to reach an appropriate level of anesthesia in patients with obstructive...
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Giant Y79 retinoblastoma cells contain functionally active T-type calcium channels
Retinoblastoma is the most common malignant intraocular tumor in children. Y79 human retinoblastoma cells are in vitro models of retinal tumors used...
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Inhibition of late sodium current via PI3K/Akt signaling prevents cellular remodeling in tachypacing-induced HL-1 atrial myocytes
An aberrant late sodium current ( I Na,Late ) caused by a mutation in the cardiac sodium channel (Na v 1.5) has emerged as a contributor to electrical...
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Retina-attached slice recording reveals light-triggered tonic GABA signaling in suprachiasmatic nucleus
Light is a powerful external cue modulating the biological rhythm of internal clock neurons in the suprachiasmatic nucleus (SCN). GABA signaling in...
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Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex
BackgroundThe development and persistence of addiction is mediated in part by drug-induced alterations in nucleus accumbens (NAc) function. AMPA-type...
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Common and Rare Variants in TMEM175 Gene Concur to the Pathogenesis of Parkinson’s Disease in Italian Patients
Parkinson’s disease (PD) represents the most common neurodegenerative movement disorder. We recently identified 16 novel genes associated with PD. In...
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Dendritic Patch
So far, we have discussed patch clamp procedures that target the neuronal soma. However, electrical properties of neurons are critically influenced...
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Repetitive transcranial magnetic stimulation enhances the neuronal excitability of mice by regulating dynamic characteristics of Granule cells’ Ion channels
This study aims to explore the effects of acute high-frequency repetitive transcranial magnetic stimulation (hf-rTMS) on neuronal excitability of...
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Whole-Cell Patch-Clamp Electrophysiology to Study Ionotropic Glutamatergic Receptors and Their Roles in Addiction
Development of the whole-cell patch-clamp electrophysiology technique has allowed for enhanced visualization and experimentation of ionic currents in...
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SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs
De novo missense mutations in SCN8A gene encoding voltage-gated sodium channel Na V 1.6 are linked to a severe form of early infantile epileptic...
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Rapid antidepressant-like effects of muscarinic receptor antagonists require BDNF-dependent signaling in the ventrolateral periaqueductal gray
RationaleClinical reports reveal that scopolamine, an acetylcholine muscarinic receptor antagonist, exerts rapid antidepressant effects in depressed...
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Differential regulation of medium spiny and cholinergic neurons in the nucleus accumbens core by the insular and medial prefrontal cortices in the rat
The nucleus accumbens (NAc) receives cortical projections principally from the insular cortex (IC) and medial prefrontal cortex (mPFC). Among NAc...
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Regulation of TRPV1 channel in monosodium urate-induced gouty arthritis in mice
ObjectiveThe transient receptor potential vanilloid subtype 1 (TRPV1) channel is considered to play an important regulatory role in the process of...
