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Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling
BackgroundVascular calcification is a major cause of the high morbidity and mortality of cardiovascular diseases and is closely associated with the...
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Extracellular Vesicles and Vascular Activity
Extracellular vesicles (EVs) are lipd bilayer-delimited extracellular particles released from almost all types of cell that carry rich cargo...
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Progress in extracellular vesicle homeostasis as it relates to cardiovascular diseases
Extracellular vesicles (EVs) are involved in both physiological and pathological processes in many organ systems and are essential in mediating...
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RGS2 and female common diseases: a guard of women’s health
Currently, women around the world are still suffering from various female common diseases with the high incidence, such as ovarian cancer, uterine...
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Unwinding circular RNA’s role in inflammatory pulmonary diseases
Circular RNAs (circRNAs) have emerged as pivotal regulators of gene expression and cellular processes in various physiological and pathological...
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Updated Understanding of the Glial-Vascular Unit in Central Nervous System Disorders
The concept of the glial-vascular unit (GVU) was raised recently to emphasize the close associations between brain cells and cerebral vessels, and...
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β1 integrins play a critical role maintaining vascular integrity in the hypoxic spinal cord, particularly in white matter
Interactions between extracellular matrix (ECM) proteins and β1 integrins play an essential role maintaining vascular integrity in the brain,...
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Potential Roles of Nr4a3-Mediated Inflammation in Immunological and Neurological Diseases
As a protein of the orphan nuclear receptor Nr4a family, Nr4a3 has no identified natural ligands. However, its biological activity can be mediated by...
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GPCRs involved in metabolic diseases: pharmacotherapeutic development updates
G protein-coupled receptors (GPCRs) are expressed in a variety of cell types and tissues, and activation of GPCRs is involved in enormous metabolic...
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Exploring the role of ITGB6: fibrosis, cancer, and other diseases
Integrin β6 (ITGB6), a member of the integrin family of proteins, is only present in epithelial tissues and frequently associates with integrin...
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PRMT3 methylates HIF-1α to enhance the vascular calcification induced by chronic kidney disease
BackgroundMedial vascular calcification is commonly identified in chronic kidney disease (CKD) patients and seriously affects the health and life...
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Single-cell analysis in rheumatic and allergic diseases: insights for clinical practice
Since the advent of single-cell RNA sequencing (scRNA-seq) methodology, single-cell analysis has become a powerful tool for exploration of cellular...
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MicroRNAs in Neurodegenerative Diseases
MicroRNAs (miRNAs) represent the first and most prominent group of abundant small non-coding RNA molecules discovered to interfere with gene...
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Modeling the neuroimmune system in Alzheimer’s and Parkinson’s diseases
Parkinson’s disease (PD) and Alzheimer’s disease (AD) are neurodegenerative disorders caused by the interaction of genetic, environmental, and...
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Application of mendelian randomization in ocular diseases: a review
Ocular disorders can significantly lower patients’ quality of life and impose an economic burden on families and society. However, for the majority...
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Inhibition of mitochondrial phosphate carrier prevents high phosphate-induced superoxide generation and vascular calcification
Vascular calcification is a serious complication of hyperphosphatemia that causes cardiovascular morbidity and mortality. Previous studies have...
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Unraveling the Potential of EphA4: A Breakthrough Target and Beacon of Hope for Neurological Diseases
Erythropoietin-producing hepatocellular carcinoma A4 (EphA4) is a transmembrane receptor protein which is a part of the most prominent family of...
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A phenomenological model of pulsatile blood pressure-affected degradation of polylactic acid (PLA) vascular stent
The stent implantation may alter the post-operative patient’s blood pressure, and bioresorbable vascular stents (BVS) as a candidate to treat...
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The emerging roles of SUMOylation in pulmonary diseases
Small ubiquitin-like modifier mediated modification (SUMOylation) is a critical post-translational modification that has a broad spectrum of...
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Nucleic acid and protein methylation modification in renal diseases
Although great efforts have been made to elucidate the pathological mechanisms of renal diseases and potential prevention and treatment targets that...
