Search
Search Results
-
Genotype-phenotype correlation in CLCN4-related developmental and epileptic encephalopathy
CLCN4 -related disorder is a rare X-linked neurodevelopmental condition with a pathogenic mechanism yet to be elucidated. CLCN4 encodes the vesicular...
-
A subthalamo-parabrachial glutamatergic pathway is involved in stress-induced self-grooming in mice
Excessive self-grooming is an important behavioral phenotype of the stress response in rodents. Elucidating the neural circuit that regulates...
-
Electrophysiological Recording Techniques from Human Dorsal Root Ganglion
While genetic tools and techniques developed in the mouse have enabled researchers to address questions many thought could never be answered, the...
-
NAADP-Dependent TPC Current
Two-pore channels, TPC1 and TPC2, are Ca2+- and Na+-permeable cation channels expressed on the membranes of endosomes and lysosomes in nearly all...
-
Characterization of hERG K+ channel inhibition by the new class III antiarrhythmic drug cavutilide
Cavutilide (niferidil, refralon) is a new class III antiarrhythmic drug which effectively terminates persistent atrial fibrillation (AF; 84.6% of...
-
The grapefruit polyphenol naringenin inhibits multiple cardiac ion channels
Drinking fresh grapefruit juice is associated with a significant prolongation of the QT segment on the electrocardiogram (ECG) in healthy volunteers....
-
CCL2 Potentiates Inflammation Pain and Related Anxiety-Like Behavior Through NMDA Signaling in Anterior Cingulate Cortex
Previous studies have shown that the C-C motif chemokine ligand 2 (CCL2) is widely expressed in the nervous system and involved in regulating the...
-
Role of TPEN in Amyloid-β25–35-Induced Neuronal Damage Correlating with Recovery of Intracellular Zn2+ and Intracellular Ca2+ Overloading
The overproduction of neurotoxic amyloid-β (Aβ) peptides in the brain is a hallmark of Alzheimer’s disease (AD). To determine the role of...
-
Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1
Familial hemiplegic migraine type-1 (FHM-1) is a form of migraine with aura caused by mutations in the P/Q-type (Cav2.1) voltage-gated calcium...
-
Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation
BackgroundAbnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with Alzheimer’s disease (AD)....
-
Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption
ObjectivesNeuroinflammation has been suggested that affects the processing of depression. There is renewed interest in berberine owing to its...
-
Sex differences in behavior, cognitive, and physiological recovery following methamphetamine administration
Intact executive functions are required for proper performance of cognitive tasks and relies on balance of excitatory and inhibitory (E/I)...
-
α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis
The major neuropathologic feature of Parkinson’s disease is the presence of widespread intracellular inclusions of α-synuclein known as Lewy bodies....
-
Cerebellar dopamine D2 receptors regulate social behaviors
The cerebellum, a primary brain structure involved in the control of sensorimotor tasks, also contributes to higher cognitive functions including...
-
Proteome and Membrane Channels
In this chapter, you will learn about the methods for analyzing a proteome. After looking at the classical method of 2D electrophoresis, we will...
-
NMDAR-dependent somatic potentiation of synaptic inputs is correlated with β amyloid-mediated neuronal hyperactivity
Backgroundβ Amyloid (Aβ)-mediated neuronal hyperactivity, a key feature of the early stage of Alzheimer’s disease (AD), is recently proposed to be...
-
Targeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling
BackgroundMyocarditis substantially increases the risk of ventricular arrhythmia. Approximately 30% of all ventricular arrhythmia cases in patients...
-
Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson’s Disease
Pain in Parkinson’s disease (PD) is increasingly recognized as a major factor associated with poor life quality of PD patients. However, classic...
-
Electrophysiology: From Molecule to Cognition, from Animal to Human
Electrophysiology is the field of study that examines physiological signals of the brain. It ranges from assessment of molecular activity using patch...
-
Forced activation of dystrophin transcription by CRISPR/dCas9 reduced arrhythmia susceptibility via restoring membrane Nav1.5 distribution
Dystrophin deficiency due to genetic mutations causes cardiac abnormalities in Duchenne’s muscular dystrophy. Dystrophin is also shown to be...
