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Attenuation of COX-2 enzyme by modulating H2O2-mediated NF-κB signaling pathway by monoamine oxidase inhibitor (MAOI): a further study on the reprofiling of MAOI in acute inflammation
ObjectiveThis study aims to investigate the anti-inflammatory mechanism of monoamine oxidase inhibitor (MAOI) in carrageenan (CARR) induced...
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A Comprehensive Review on the Effect of Natural Products on Colorectal Cancer
Purpose of ReviewThis article provides insight and information on selected natural products against colorectal cancer and its mechanism of action.
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Emerging Advances in Nanocarriers Approaches in the Effective Therapy of Pain Related Disorders: Recent Evidence and Futuristic Needs
Pain disorders are the primary cause of disability nowadays. These disorders, such as rheumatoid arthritis (RA) and osteoarthritis (OA), cause loss...
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Protective effects of (4-(1,2,4-oxadiazol-5-yl)phenyl)-2-aminoacetamide derivatives to adjuvant-induced arthritis rats by regulating the NF-κB signaling pathway
A series of (4-(1,2,4-oxadiazol-5-yl) phenyl)-2-aminoacetamide derivatives showed good anti-neuroinflammation in our previous study. Some studies...
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A raising dawn of pentoxifylline in management of inflammatory disorders in Covid-19
The existing pandemic viral infection caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) leads to coronavirus disease 2019...
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Therapeutic Effects of Withania somnifera: An Overview with Special Focus on Alzheimer’s Disease and Infertility among Youth
Immunomodulators are biomolecules that are recognized for their characteristics to stimulate or suppress the adaptive or innate immunity. These...
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LC-QToF chemical profiling of Euphorbia grantii Oliv. and its potential to inhibit LPS-induced lung inflammation in rats via the NF-κB, CY450P2E1, and P38 MAPK14 pathways
Acute lung injury (ALI) is a life-threatening syndrome that causes high morbidity and mortality worldwide. The aerial parts of Euphorbia grantii ...
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Antileishmanial Agents Co-loaded in Transfersomes with Enhanced Macrophage Uptake and Reduced Toxicity
The prime objective of this study was to develop amphotericin B (AMB) and rifampicin (RIF) co-loaded transfersomal gel (AMB-RIF co-loaded TFG) for...
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Experimental investigation and molecular simulations of quinone related compounds as COX/LOX inhibitors
Quinone-containing compounds have risen as promising anti-inflammatory targets; however, very little research has been directed to investigate their...
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Licofelone Attenuates Acetic Acid-Induced Colitis in Rats Through Suppression of the Inflammatory Mediators
Licofelone is a dual Cyclooxygenase 1,2 (COX1,2)/5-lipoxygenase) 5-LOX (inhibitor with analgesic and anti-inflammatory effects with possible...
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1,4-Diaryl-1,2,3-triazole neolignan–celecoxib hybrids inhibit experimental arthritis induced by zymosan
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes cartilage damage. Anti-inflammatories are widely used in the management of RA,...
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Inflammatory biomarkers on an LPS-induced RAW 264.7 cell model: a systematic review and meta-analysis
IntroductionSeveral experimental models have been designed to promote the development of new anti-inflammatory drugs. The in vitro model using RAW...
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Andrographolide inhibits the activation of spinal microglia and ameliorates mechanical allodynia
Andrographolide (Andro), a labdane diterpene, possesses anti-inflammatory properties and has been used to treat numerous inflammatory diseases. Novel...
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Current trends in epigenetic, cellular and molecular pathways in management of rheumatoid arthritis
Rheumatoid arthritis is a systemic chronic polyarticular autoimmune disorder of joints and joint membrane mainly affecting feet and hands. The...
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Role of Indian Ginseng Withaferin A in ROS-Induced Cancer Chemoprevention and Cancer Therapy
In the fast-moving world, although the opening doors to the advancements in oncological therapies are wide, the cure for cancer remains still a...
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Role of Indian Ginseng Withaferin A in ROS-Induced Cancer Chemoprevention and Cancer Therapy
In the fast-moving world, although the opening doors to the advancements in oncological therapies are wide, the cure for cancer remains still a...
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Plant Immunoenhancers: Promising Ethnopharmacological Candidates for Anti-SARS-CoV-2 Activity
Medicinal plants have gained attention for their bioactive phytochemicals, affordability, patient-friendly nature, and avoidance of synthetic drug...
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Nonsteroidal Anti-inflammatory Drugs
NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) are the most widely used medicines globally. NSAIDs relieve pain (analgesic effect) and fever...
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Genotype–phenotype correlation in IBD: unveiling putative inhibitors for IL10RA and IRF5 variants—an in silico analysis
Despite recent advances, the majority of the susceptibility genes for inflammatory bowel disease (IBD), a chronic inflammatory disorder that affects...
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Exploring the pivotal role of endothelin in rheumatoid arthritis
A chronic inflammatory disorder, rheumatoid arthritis (RA) is an autoimmune and systemic disease characterized by progressive and prolonged...
