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Nomogram for predicting lymph node metastasis in patients with ovarian cancer using ultrasonography: a multicenter retrospective study
BackgroundOvarian cancer is a common cancer among women globally, and the assessment of lymph node metastasis plays a crucial role in the treatment...
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EIF4A3-mediated biogenesis of circSTX6 promotes bladder cancer metastasis and cisplatin resistance
BackgroundCisplatin (CDDP)-based chemotherapy is a standard first-line treatment for metastatic bladder cancer (BCa) patients, and chemoresistance...
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Prognostic factors and the role of primary debulking in operable stage IVB ovarian cancer with supraclavicular lymph node metastasis: a retrospective study in Chinese patients
BackgroundRecent studies showed heterogeneity in stage IVB patients. However, few studies focused on the prognosis of supraclavicular metastatic...
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Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics
Most of the cancer-associated mortality and morbidity can be attributed to metastasis. The role of epigenetic and epitranscriptomic alterations in...
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RETRACTED ARTICLE: KRAS activation in gastric cancer stem-like cells promotes tumor angiogenesis and metastasis
Our previous work showed that KRAS activation in gastric cancer cells leads to activation of an epithelial-to-mesenchymal transition (EMT) program...
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Tumor-associated macrophages in colorectal cancer metastasis: molecular insights and translational perspectives
Metastasis is the leading cause of high mortality in colorectal cancer (CRC), which is not only driven by changes occurring within the tumor cells,...
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Pathologic Assessment of Lymph Node Metastasis
The pathologic assessment and evaluation of lymph node status plays a central role in the diagnosis, staging, and management of most malignancies....
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From pre-clinical to translational brain metastasis research: current challenges and emerging opportunities
Brain metastasis, characterized by poor clinical outcomes, is a devastating disease. Despite significant mechanistic and therapeutic advances in...
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Mechanisms Underlying Tumor-Associated Macrophages (TAMs)-Facilitated Metastasis
Metastasis is responsible for more than 90% of cancer deaths, but remains the least understood stage of tumor progression. The tumor microenvironment...
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Metastasis-associated fibroblasts in peritoneal surface malignancies
Over decades, peritoneal surface malignancies (PSMs) have been associated with limited treatment options and poor prognosis. However, advancements in...
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ZEB1-mediated biogenesis of circNIPBL sustains the metastasis of bladder cancer via Wnt/β-catenin pathway
BackgroundCircular RNAs (circRNAs) circularized by back-splicing of pre-mRNA are widely expressed and affected the proliferation, invasion and...
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Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis
Lymphangiogenesis is an essential physiological process but also a determining factor in vascular-related pathological conditions. Angiopoietin-2...
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Development of a novel murine model of lymphatic metastasis
Current laboratory models of lymphatic metastasis generally require either genetically modified animals or are technically challenging. Herein, we...
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SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma
Macrophages are heterogeneous cells that play multifaceted roles in cancer progression and metastasis. However, the phenotypic diversity of...
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Intradural extramedullary metastasis of oncocytic carcinoma of the parotid gland: A first case report and review of the literature
We present an extremely infrequent case of intradural metastasis of a parotid tumour, responsible for motor deficit in legs. To our knowledge, this...
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Biology, Chemistry, and Physics of Cancer Cell Motility and Metastasis
A malignant tumor has ability to invade the nearby tissues and colonize distant sites (organs) through the lymphatic/vascular system. From...
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Isolated hyperthermic perfusions for cutaneous melanoma in-transit metastasis of the limb and uveal melanoma metastasis to the liver
Patients with cutaneous melanoma can develop in-transit metastases (ITM), most often localized to limbs. For patients with uveal melanoma that...
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CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt/β-catenin signalling pathway
BackgroundLymph node (LN) metastasis confers gastric cancer (GC) progression, poor survival and cancer-related death. Aberrant activation of...
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Implications of ZNF334 gene in lymph node metastasis of lung SCC: potential bypassing of cellular senescence
BackgroundThe primary goal of this work is to identify biomarkers associated with lung squamous cell carcinoma and assess their potential for early...
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nPTD classification: an updated classification of gastric cancer location for function preserving gastrectomy based on physiological lymphatic flow
BackgroundThe correlation between tumor location and lymphatic flow distribution in gastric cancer has been previously reported, and PTD (Proximal –...
