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1. Promoted CD4⁺ T cell-derived IFN-γ/IL-10 by photobiomodulation therapy modulates neurogenesis to ameliorate cognitive deficits in APP/PS1 and 3xTg-AD mice

   Background

   The immune system has been implicated in synaptic plasticity, inflammation, and the progression of Alzheimer's disease (AD). However, there...

   **aolei Wu, Qi Shen, ... Da **ng in Journal of Neuroinflammation

   Article Open access 10 October 2022
   

2. Small extracellular vesicles derived from PD-L1-modified mesenchymal stem cell promote Tregs differentiation and prolong allograft survival

   We aimed to explore whether programmed cell death protein-1 ligand (PD-L1) modification on small extracellular vesicles (sEVs) could promote T...

   Qifeng Ou, **aolin Dou, ... Ding Pan in Cell and Tissue Research

   Article 11 June 2022
   

3. C57Bl/6N mice have an attenuated lung inflammatory response to dsRNA compared to C57Bl/6J and BALB/c mice

   Background

   Lower respiratory infections caused by ssRNA viruses are a major health burden globally. Translational mouse models are a valuable tool for...

   Sofia Malm Tillgren, Juan José Nieto-Fontarigo, ... Lena Uller in Journal of Inflammation

   Article Open access 21 February 2023
   

4. Host Interferon-Stimulated Gene 20 Inhibits Pseudorabies Virus Proliferation

   Host interferon-stimulated gene 20 (ISG20) exerts antiviral effects on viruses by degrading viral RNA or by enhancing IFN signaling. Here, we...

   **aoyong Chen, Dage Sun, ... Guangzhi Tong in Virologica Sinica

   Article 08 April 2021
   

5. A Time and Cost-Effective Pipeline for Expression Screening and Protein Production in Insect Cells Based on the HR-Bac Toolbox to Generate Recombinant Baculoviruses

   The baculovirus expression vector system (BEVS) is recognized as a powerful platform for producing challenging proteins and multiprotein complexes...

   Jules Loup-Forest, Manon Matuchet, ... Arnaud Poterszman in Baculovirus

   Protocol 2024
   

6. Immunomodulatory effects of umbilical mesenchymal stem cell-derived exosomes on CD4⁺ T cells in patients with primary Sjögren's syndrome

   Background

   Primary Sjögren's syndrome (pSS) is an autoimmune disease that leads to the destruction of exocrine glands and multisystem lesions....

   Dan Ma, Zewen Wu, ... Liyun Zhang in Inflammopharmacology

   Article Open access 03 April 2023
   

7. In vitro and in vivo analyses of co-infections with peste des petits ruminants and capripox vaccine strains

   Background

   Peste des petits ruminants (PPR) and goat pox (GTP) are two devastating animal epidemic diseases that affect small ruminants. Vaccination...

   Dajun Zhang, Bo Yang, ... Keshan Zhang in Virology Journal

   Article Open access 07 April 2021
   

8. A novel probiotic strain exerts therapeutic effects on mouse model of multiple sclerosis by altering the expression of inflammasome and IDO genes and modulation of T helper cytokine profile

   Multiple sclerosis is an inflammatory demyelinating disease that commences to neuronal cell destruction. Recently, a promising evidence of synergic...

   Saba Sadeghirashed, Fatemeh Kazemi, ... Javad Arasteh in Metabolic Brain Disease

   Article 10 November 2021
   

9. SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation

   SARS-CoV-2 is the pathogenic agent of COVID-19, which has evolved into a global pandemic. Compared with some other respiratory RNA viruses,...

   Wen**g Wang, Zhuo Zhou, ... Jianwei Wang in Cellular & Molecular Immunology

   Article Open access 26 February 2021
   

10. Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3C^pro

    Enteroviruses (EVs) 3C proteins suppress type I interferon (IFN) responses mediated by retinoid acid-inducible gene I (RIG-I), while an E3 ubiquitin...

    Huimin **ao, **gliang Li, ... Wenyan Zhang in Virologica Sinica

    Article 25 June 2021
    

11. COVID-19 and the role of cytokines in this disease

    Studies have shown that SARS-CoV-2 has the ability to activate and mature proinflammatory cytokines in the body. Cytokine markers are a group of...

    Amin Hasanvand in Inflammopharmacology

    Article 04 May 2022

12. Immunostimulatory siRNA with a uridine bulge leads to potent inhibition of HBV and activation of innate immunity

    Background

    Hepatitis B virus (HBV) infection is difficult to cure. HBV-specific immune tolerance plays a key role in HBV persistence, and enhancing...

    Tingyu Lan, Zhiqiang Wei, ... Zhongji Meng in Virology Journal

    Article Open access 18 February 2021
    

13. Transforming growth factor β as a possible independent factor in chronic hepatitis B

    To investigate the association between immune-cell-related cytokines and the development of chronic hepatitis B (CHB), patients with chronic...

    Ming-hui Li, Yao Lu, ... Yao **e in Archives of Virology

    Article 19 April 2021
    

14. Viperin deficiency promotes dendritic cell activation and function via NF-kappaB activation during Mycobacterium tuberculosis infection

    Objectives and design

    Dendritic cells (DCs) are one of the key immune cells in bridging innate and adaptive immune response against Mycobacterium...

    **nying Zhou, Hui Xu, ... Li Ma in Inflammation Research

    Article Open access 31 October 2022
    

15. Interferon-beta enhances sensitivity to gemcitabine in pancreatic cancer

    Background

    Adjuvant gemcitabine for pancreatic cancer has limited efficacy in the clinical setting. Impaired drug metabolism is associated with...

    Amber Blaauboer, Stephanie Booy, ... Leo J. Hofland in BMC Cancer

    Article Open access 23 September 2020
    

16. Altered IFN-γ Levels after Treatment of Epileptic Patients with Omega-3 Fatty Acids

    Epilepsy is a frequent chronic disorder of the brain characterized by intermittent epileptic seizures caused by hypersynchronous discharge of neurons...

    Soudeh Ghafouri-Fard, Mahnaz Hashemi, ... Mohammad Taheri in Journal of Molecular Neuroscience

    Article 12 February 2021
    

17. The immunoregulatory landscape of human tuberculosis granulomas

    Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in infected tissues, the architecture and composition of which...

    Erin F. McCaffrey, Michele Donato, ... Michael Angelo in Nature Immunology

    Article Open access 20 January 2022
    

18. Native and IgE-primed rat peritoneal mast cells exert pro-inflammatory activity and migrate in response to yeast zymosan upon Dectin-1 engagement

    Mast cells (MCs) play an essential role in host defense, primarily because of their location, their ability to pathogen destruction via several...

    Paulina Żelechowska, Ewa Brzezińska-Błaszczyk, ... Elżbieta Kozłowska in Immunologic Research

    Article Open access 11 March 2021
    

19. Black Seed (Nigella sativa): A Favourable Alternative Therapy for Inflammatory and Immune System Disorders

    In the recent years, various food additives, medicinal plants, and their bioactive components have been utilized in anti-inflammatory and...

    Opeyemi Oluwafemi Ojueromi, Ganiyu Oboh, Ayokunle Olubode Ademosun in Inflammopharmacology

    Article 16 August 2022
    

20. Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses

    Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs) proinflammatory...

    Yujuan Chen, Junhong Lin, ... Huashan Yi in Journal of Zhejiang University-SCIENCE B

    Article 01 July 2021