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The identification of effective tumor-suppressing neoantigens using a tumor-reactive TIL TCR-pMHC ternary complex
Neoantigens are ideal targets for cancer immunotherapy because they are expressed de novo in tumor tissue but not in healthy tissue and are therefore...
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AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis
BackgroundBasal-like breast cancer (BLBC) is the most aggressive subtype of breast cancer due to its aggressive characteristics and lack of effective...
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Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells
PurposeThe goal of this study was to characterize the relationship between ATR and STAT3 interactions in human multiple myeloma (MM) cells.
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Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors
BackgroundThe oncogenic activity of the high risk human papillomavirus type 16 (HPV16) is fully dependent on the E6 and E7 viral oncoproteins...
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Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression
BackgroundSLC5A7 (solute carrier family 5 member 7), also known as choline transporter 1 (CHT1), is downregulated in colorectal cancer (CRC) and...
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Discovery of a small molecule ligand of FRS2 that inhibits invasion and tumor growth
PurposeAberrant activation of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases drives oncogenic signaling through its...
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Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells
The effectiveness of chimaeric antigen receptor (CAR) T-cell immunotherapies against solid tumours relies on the accumulation, proliferation and...
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Triggering pyroptosis enhances the antitumor efficacy of PARP inhibitors in prostate cancer
PurposePARP inhibitors have revolutionized the treatment landscape for advanced prostate cancer (PCa) patients who harboring mutations in homologous...
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Comparative genomics of the T cell receptor μ locus in marsupials and monotremes
T cells are a primary component of the vertebrate adaptive immune system. There are three mammalian T cell lineages based on their T cell receptors...
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Primer Design for the Analysis of Closely Related Species: Application of Noncoding mtDNA and cpDNA Sequences
Noncoding regions of the chloroplast (cpDNA) and mitochondrial (mtDNA) genomes are commonly used in plant phylogenetic and population studies....
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A 192 bp ERV fragment insertion in the first intron of porcine TLR6 may act as an enhancer associated with the increased expressions of TLR6 and TLR1
BackgroundToll-like receptors (TLRs) play important roles in building innate immune and inducing adaptive immune responses. Associations of the TLR ...
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Transcriptome Profiling Analysis Identifies LCP1 as a Contributor for Chidamide Resistance in Gastric Cancer
BackgroundGastric cancer (GC) remains a significant health problem and carries with it substantial morbidity and mortality. Chidamide is a novel and...
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A novel SLC5A2 heterozygous variant in a family with familial renal glucosuria
Familial renal glucosuria (FRG) is characterized by persistent glucosuria despite normal blood glucose levels in the absence of overt tubular...
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KRASG12C inhibition using MRTX1257: a novel radio-sensitizing partner
BackgroundKRAS activating mutations are considered the most frequent oncogenic drivers and are correlated with radio-resistance in multiple cancers...
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METTL3 suppresses pancreatic ductal adenocarcinoma progression through activating endogenous dsRNA-induced anti-tumor immunity
PurposeAlthough immunotherapy improves clinical outcomes in several types of malignancies, as an immunologically ‘cold’ tumor, pancreatic ductal...
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Suspected olfactory meningioma and synchronous pituitary microadenoma in a canine patient treated with radiation therapy
The authors report on the rare occurrence of dual synchronous primary brain tumors in a canine patient, successful treatment with radiation therapy,...
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A novel complement-fixing IgM antibody targeting GPC1 as a useful immunotherapeutic strategy for the treatment of pancreatic ductal adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with a very low survival rate at 5 years. The use of...
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circ-TFRC downregulation suppresses ovarian cancer progression via miR-615-3p/IGF2 axis regulation
BackgroundOvarian cancer (OC) is a malignancy among female globally. Circular RNAs (circRNAs) are a family of circular endogenous RNAs generated from...
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APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells
BackgroundAberrant WNT/β-catenin signaling drives carcinogenesis. Tankyrases poly(ADP-ribosyl)ate and destabilize AXINs, β-catenin repressors....
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Survival time prediction in patients with high-grade serous ovarian cancer based on 18F-FDG PET/CT- derived inter-tumor heterogeneity metrics
BackgroundThe presence of heterogeneity is a significant attribute within the context of ovarian cancer. This study aimed to assess the predictive...
