Search
Search Results
-
Synergistic antitumor efficacy of PD-1-conjugated PTX- and ZSQ-loaded nanoliposomes against multidrug-resistant liver cancers
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with poor chemotherapeutic efficiency due to multidrug resistance...
-
Immune-Mediated Liver Disease in the Transplanted Liver
Liver transplantation has evolved as the treatment of choice for many patients with end-stage liver disease. Currently, survival posttransplant is...
-
Sorafenib and edaravone protect against renal fibrosis induced by unilateral ureteral obstruction via inhibition of oxidative stress, inflammation, and RIPK-3/MLKL pathway
Renal fibrosis is the common endpoint of nearly all chronic and progressive nephropathies. Cell death and sterile inflammation are the main...
-
Indomethacin Combined with Ciprofloxacin Improves the Prognosis of Mice under Severe Traumatic Infection via the PI3K/Akt Pathway in Macrophages
The prevention and treatment strategies for traumatic infection often focus on the use of antibiotics, while eschew the combined treatment of the...
-
Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration in male rats
In this study, we investigated the effects of grape seed proanthocyanidin extract (GSPE) against the side effects of high-dose administration of...
-
Progranulin Facilitates Corneal Repair Through Dual Mechanisms of Inflammation Suppression and Regeneration Promotion
The cornea serves as a vital protective barrier for the eye; however, it is prone to injury and damage that can disrupt corneal epithelium and...
-
The significant mechanism and treatments of cell death in heatstroke
With global warming, extreme environmental heat is becoming a social issue of concern, which can cause adverse health results including heatstroke...
-
Recommended Resources for Biomarkers in Disease: Trauma, Injury, and Critical Care
It is extremely challenging to assess some victims of trauma, injury, or critical care. An accurate history may be difficult to obtain, and imaging...
-
Applications of 3D organoids in toxicological studies: a comprehensive analysis based on bibliometrics and advances in toxicological mechanisms
A mechanism exploration is an important part of toxicological studies. However, traditional cell and animal models can no longer meet the current...
-
Recovery from antibody-mediated biliary ductopenia and multiorgan inflammation after COVID-19 vaccination
The coronavirus disease 2019 (COVID-19) pandemic has caused significant morbidity and mortality. Spike messenger RNA (mRNA)–based vaccines against...
-
Inflammatory setting, therapeutic strategies targeting some pro-inflammatory cytokines and pathways in mitigating ischemia/reperfusion-induced hepatic injury: a comprehensive review
Ischemia/reperfusion injury (IRI) is a key determining agent in the pathophysiology of clinical organ dysfunction. It is characterized by an aseptic...
-
Mechanisms and in vitro models of drug-induced cholestasis
Cholestasis underlies one of the major manifestations of drug-induced liver injury. Drug-induced cholestatic liver toxicity is a complex process, as...
-
Plasma biomarkers TAP, CPA1, and CPA2 for the detection of pancreatic injury in rat: the development of a novel multiplex IA-LC-MS/MS assay and biomarker performance evaluation
Drug-induced pancreatic injury (DIPI) is an issue seen in drug development both in nonclinical and clinical contexts. DIPI is typically monitored by...
-
Management of Fluoropyrimidine-Induced Cardiac Adverse Outcomes Following Cancer Treatment
Advancements in cancer treatments have improved survival rates but have also led to increased cardiotoxicities, which can cause adverse...
-
Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease
The liver is an important immunological organ that controls systemic tolerance. The liver harbors professional and unconventional antigen-presenting...
-
Renin-Angiotensin-Aldosterone System Role in Organ Fibrosis
The normal healing process secondary to injury, disease or toxins is a mandatory process to human life. The healing process begins with hemostasis,...
-
Pharmacological Modeling of Gastrointestinal Disorders in Zebrafish for Drug Discovery and Development
Zebrafish as a pharmacological model is gaining popularity due to its similarity in both transcriptional and developmental physiology with humans. In...
-
Investigating the Anti-inflammatory Effect of Quinoline Derivative: N1-(5-methyl-5H-indolo[2,3-b]quinolin-11-yl)benzene-1,4-diamine Hydrochloride Loaded Soluble Starch Nanoparticles Against Methotrexate-induced Inflammation in Experimental Model
BackgroundIt is necessary to develop advanced therapies utilizing natural ingredients with anti-inflammatory qualities in order to lessen the...
-
Naringenin suppresses aluminum-induced experimental hepato-nephrotoxicity in mice through modulation of oxidative stress and inflammation
Aluminum is a widely used metal substance in daily life activities that has been shown to cause severe hepato-nephrotoxicity with long-term exposure....
-
Biomaterials and Microfluidics for Liver Models
Over the past years, important progresses have been made in the field of tissue engineering. Many of the early trials to improve the development of...