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Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence
Candida auris is an emerging pathogenic yeast that has been categorized as a global public health threat and a critical priority among fungal...
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Elicitation of T-cell-derived IFN-γ-dependent immunity by highly conserved Plasmodium ovale curtisi Duffy binding protein domain region II (PocDBP-RII)
BackgroundInfections with Plasmodium ovale are widely distributed but rarely investigated, and the resulting burden of disease has been...
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Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation
Primary Sjögren’s syndrome (pSS) is a chronic inflammatory autoimmune disease with an unclear pathogenesis, and there is currently no approved drug...
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A novel prostaglandin I2 agonist, ONO-1301, attenuates liver inflammation and suppresses fibrosis in non-alcoholic steatohepatitis model mice
BackgroundONO-1301 is a novel long-lasting prostaglandin (PG) I 2 mimetic with inhibitory activity on thromboxane (TX) A 2 synthase. This drug can...
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The Pathophysiology of Liver Disorders and Pharmacotherapy Options with Special Reference to Traditional Herbal Medicines: A Comprehensive Review
Besides synthetic drugs, a wide variety of medicinal plants have been used for the prevention and management of various liver disorders. Generally,...
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Hydrogels as Smart Drug Delivery Systems: Recent Advances
Hydrogels are cross-linked three-dimensional (3D) polymeric networks capable of absorbing and holding a vast amount of water in their swollen state....
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RNA m6A regulates transcription via DNA demethylation and chromatin accessibility
Transcriptional regulation, which integrates chromatin accessibility, transcription factors and epigenetic modifications, is crucial for establishing...
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Molecular characterization and functional implications on mouse peripheral blood mononuclear cells of annexin proteins from Echinococcus granulosus sensu lato
BackgroundCystic echinococcosis (CE) is a life-threatening zoonotic disease caused by the larval stage of Echinococcus granulosus sensu lato, which...
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Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens
Antigen receptor loci are organized into variable (V), diversity (D) and joining (J) gene segments that rearrange to generate antigen receptor...
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Quantifying the Mechanical Properties of Yeast Candida albicans Using Atomic Force Microscopy-based Force Spectroscopy
Fungi can adapt to a wide range of environmental stresses in the wild and host milieu by employing their plastic genome and great diversity in...
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Comparative Molecular and Biological Characteristic of the Systemic Inflammatory Response in Adult and Old Male Wistar Rats with Different Resistance to Hypoxia
Morphological, molecular, and biological features of the systemic inflammatory response induced by LPS administration were assessed in adult and old...
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Regulatory effects of a novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae on mice immune cells
BackgroundThe giant panda ( Ailuropoda melanoleuca ) is a well-known, rare and endangered species. Baylisascaris schroederi is a pathogenic ascarid....
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Concanavalin A Induces Cortical Neuron Apoptosis by Causing ROS Accumulation and Tyrosine Kinase Activation
The lectin, concanavalin A (Con A), is the most extensively investigated member of the lectin family of plant proteins, but its effects on cortical...
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A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge
BackgroundHuman enteroviruses A71 (EV-A71) and D68 (EV-D68) are the suspected causative agents of hand-foot-and-mouth disease, aseptic meningitis,...
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NF-κB regulation by bisbenzylisoquinoline alkaloids in human T cells: a structure–activity relationship study
Suppressive potencies of tetrandrine, isotetrandrine, fangchinoline, berbamine, dauricine, cepharanthine, and armepavine on expression and activation...
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Implications for the Predictivity of Cell-Based Developmental Toxicity Assays Developed Two Decades Apart
Many in vitro developmental toxicity assays have been proposed over several decades. Since the late 1980s, we have made intermittent attempts to...
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Vaccines for human fungal diseases: close but still a long way to go
Despite the substantial global burden of human fungal infections, there are no approved fungal vaccines to protect at risk individuals. Here, we...
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Therapeutic potential of thymoquinone and its nanoformulations in neuropsychological disorders: a comprehensive review on molecular mechanisms in preclinical studies
Thymoquinone (THQ) and its nanoformulation (NFs) have emerged as promising candidates for the treatment of neurological diseases due to their diverse...
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Natural Product-Based Anti-Viral Agents Against RNA Viruses: An Important Strategy for Pandemic Preparedness
Anthropogenic factors and climate changes result in the emergence and re-emergence of infectious diseases. Viruses are one of the major causative...