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From complexity to clarity: unravelling tumor heterogeneity through the lens of tumor microenvironment for innovative cancer therapy
Despite the tremendous clinical successes recorded in the landscape of cancer therapy, tumor heterogeneity remains a formidable challenge to...
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Nasopharyngeal carcinoma: current views on the tumor microenvironment's impact on drug resistance and clinical outcomes
The incidence of nasopharyngeal carcinoma (NPC) exhibits significant variations across different ethnic groups and geographical regions, with...
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MicroRNAs and the Mediterranean diet: a nutri-omics perspective for lung cancer
Lung cancer is the deadliest cancer type worldwide with ~ 1.8 million deaths per-year. Smoking accounts for ~ 85% of all cases, with a described...
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FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA
BackgroundParkinson's disease (PD), characterized by the progressive loss of dopaminergic neurons in the substantia nigra and striatum of brain,...
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Exosome nanovesicles as potential biomarkers and immune checkpoint signaling modulators in lung cancer microenvironment: recent advances and emerging concepts
Lung cancer remains the leading cause of cancer-related deaths globally, and the survival rate remains low despite advances in diagnosis and...
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The Hurdle of Precision Medicine in Cancer Immunotherapy: Personalization Now or Then?
Moving away from the generic treatment for all cancer, precision medicine provides a targeted therapy based on the different profile presented. Since...
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Pathophysiology, diagnosis, and herbal medicine-based therapeutic implication of rheumatoid arthritis: an overview
Rheumatoid arthritis (RA) stands as an autoimmune disorder characterized by chronic joint inflammation, resulting in profound physiological...
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The senescence journey in cancer immunoediting
Cancer progression is continuously controlled by the immune system which can identify and destroy nascent tumor cells or inhibit metastatic...
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Trajectories of immune-related serum proteins and quality of life in patients with pancreatic and other periampullary cancer: the CHAMP study
BackgroundThere is still a profound lack of efficient therapeutic strategies against pancreatic and other periampullary adenocarcinoma. Surgery is...
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Immunoregulatory Bioactive Phytoconstituents: Recent Trends and Future Challenges
Realizing the indispensable role of the immune system in maintaining the disease-free state, concept of immunomodulation is gaining increased public...
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Role of Synbiotics in Inflammatory Lung Diseases
The microbiome of human gut or lungs is a sophisticated ecology of bacterial strains that inhabits the respiratory and digestive systems. Over the...
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Lung cancer immunotherapy: progress, pitfalls, and promises
Lung cancer is the primary cause of mortality in the United States and around the globe. Therapeutic options for lung cancer treatment include...
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The anti-estrogen receptor drug, tamoxifen, is selectively Lethal to P-glycoprotein-expressing Multidrug resistant tumor cells
BackgroundP-glycoprotein (P-gp), a member of the ATP Binding Cassette B1 subfamily (ABCB1), confers resistance to clinically relevant anticancer...
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Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma
Axicabtagene ciloleucel (axi-cel) is an anti-CD19 chimeric antigen receptor (CAR) T cell therapy approved for relapsed/refractory large B cell...
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An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis
Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. This process contributes to cellular and tissue...
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HER3 in cancer: from the bench to the bedside
The HER3 protein, that belongs to the ErbB/HER receptor tyrosine kinase (RTK) family, is expressed in several types of tumors. That fact, together...
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Exploiting temporal aspects of cancer immunotherapy
Many mechanisms underlying an effective immunotherapy-induced antitumour response are transient and critically time dependent. This is equally true...
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Histone modifications in drug-resistant cancers: From a cancer stem cell and immune evasion perspective
The development and immune evasion of cancer stem cells (CSCs) limit the efficacy of currently available anticancer therapies. Recent studies have...
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Recent applications of quantitative systems pharmacology and machine learning models across diseases
Quantitative systems pharmacology (QSP) is a quantitative and mechanistic platform describing the phenotypic interaction between drugs, biological...
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Immune Checkpoint Inhibitors as an Armor for Targeted Immunotherapy of Colorectal Cancer
Recent progress in understanding the interplay between tumor cells and immune cells has given emergence to a new field called immunotherapy. Tumor...