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Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple Myeloma
RO7297089, an anti-B-cell maturation antigen (BCMA)/CD16A bispecific tetravalent antibody, is being developed as a multiple myeloma (MM) therapeutic....
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Development of a Physiologically-Based Pharmacokinetic Model for Whole-Body Disposition of MMAE Containing Antibody-Drug Conjugate in Mice
PurposeTo quantitate and mathematically characterize the whole-body pharmacokinetics (PK) of different ADC analytes following administration of an...
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Organoid Co-culture Methods to Capture Cancer Cell–Natural Killer Cell Interactions
Metastasis is a complex process that has been historically difficult to model in culture. Host immune responses play critical roles in restraining...
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Implementing a novel capture and ligation probe-PCR method in mass screen and treatment to support malaria elimination efforts in the China-Myanmar border region
BackgroundMass screening and treatment (MSAT) for malaria elimination lacks an ideal diagnostic tool to allow sensitive and affordable test of the...
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Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens
Antigen receptor loci are organized into variable (V), diversity (D) and joining (J) gene segments that rearrange to generate antigen receptor...
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Human antibody profiling technologies for autoimmune disease
Autoimmune diseases are caused by the break-down in self-tolerance mechanisms and can result in the generation of autoantibodies specific to human...
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Quantification of the dynamics of antibody response to malaria to inform sero-surveillance in pregnant women
BackgroundMalaria remains a major public health threat and tools sensitive to detect infections in low malaria transmission areas are needed to...
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Comparison of Pre-existing Anti-AAV8 Total Antibody Screening and Confirmatory Assays with a Cell-Based Neutralizing Assay in Normal Human Serum
Pre-existing adeno-associated viruses (AAV) neutralizing antibodies (NAb) can prevent AAV vectors from transducing target tissues. The immune...
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Antiphospholipid Antibody Testing for Anti-cardiolipin and Anti-β2 Glycoprotein I Antibodies Using Chemiluminescence-Based Panels
Antiphospholipid (antibody) syndrome (APS) is a prothrombotic condition with increased risk for thrombosis and pregnancy-related morbidity. In...
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Convolutional Neural Networks Guided Raman Spectroscopy as a Process Analytical Technology (PAT) Tool for Monitoring and Simultaneous Prediction of Monoclonal Antibody Charge Variants
BackgroundCharge related heterogeneities of monoclonal antibody (mAb) based therapeutic products are increasingly being considered as a critical...
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A microfluidic paper analytical device using capture aptamers for the detection of PfLDH in blood matrices
BackgroundThe prevalence and death rate arising from malaria infection, and emergence of other diseases showing similar symptoms to malaria require...
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Anti-drug Antibody Validation Testing and Reporting Harmonization
Evolving immunogenicity assay performance expectations and a lack of harmonized anti-drug antibody validation testing and reporting tools have...
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Application of Affinity-Capture Self-Interaction Nanoparticle Spectroscopy in Predicting Protein Stability, Especially for Co-Formulated Antibodies
PurposeFrom traditional monoclonal antibodies to more and more complex mAb-based formulations, biopharmaceutical faces one challenge after another....
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Mini-PBPK-Based Population Model and Covariate Analysis to Assess the Complex Pharmacokinetics and Pharmacodynamics of RO7449135, an Anti-KLK5/KLK7 Bispecific Antibody in Cynomolgus Monkeys
RO7449135, an anti-kallikrein (KLK)5/KLK7 bispecific antibody, is in development as a potential therapy against Netherton’s syndrome (NS). In...
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The role of chromatin loop extrusion in antibody diversification
Cohesin mediates chromatin loop formation across the genome by extruding chromatin between convergently oriented CTCF-binding elements. Recent...
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Direct detection and quantification of Toxoplasma gondii in meat samples from feral raccoons (Procyon lotor) in Germany by magnetic-capture real-time PCR
Because the number of wild raccoons in Germany is increasing constantly, it appears to be economic reasonable to use their meat as food. For this...
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Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota
Serum antibodies can recognize both pathogens and commensal gut microbiota. However, our current understanding of antibody repertoires is largely...
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Antibody avidity, persistence, and response to antigen recall: comparison of vaccine adjuvants
Differences in innate immune ‘imprinting’ between vaccine adjuvants may mediate dissimilar effects on the quantity/quality of persisting adaptive...
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Integrated multiple analytes and semi-mechanistic population pharmacokinetic model of tusamitamab ravtansine, a DM4 anti-CEACAM5 antibody-drug conjugate
Tusamitamab ravtansine (SAR408701) is an antibody-drug conjugate (ADC), combining a humanized monoclonal antibody (IgG1) targeting carcinoembryonic...
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High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers
Soluble HIV-1 envelope glycoprotein (Env) immunogens are a prime constituent of candidate vaccines designed to induce broadly neutralizing...
