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Antimicrobial Stewardship: Evolution into the Twenty-First Century
Overuse and inappropriate use of antimicrobials are the key drivers in the development of antibiotic resistance. Every year, at least two million...
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Antimicrobial Resistance in Food-Borne Campylobacter spp.
Campylobacteriosis is one of the important reasons for food-related gastrointestinal infections across the world. The microaerophilic group of...
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Antimicrobial Resistance in Food-Borne Campylobacter spp.
Campylobacteriosis is one of the important reasons for food-related gastrointestinal infections across the world. The microaerophilic group of...
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Miltefosine Unresponsiveness in Visceral Leishmaniasis
Treatment failure in visceral leishmaniasis (VL; kala-azar) is an increasing problem worldwide, primarily due to drug resistance. Pentavalent...
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Chemotherapy for Drug-Susceptible Tuberculosis
The decade of 1940s brought one of the major achievements when streptomycinStreptomycin was discovered to treat tuberculosis (TB)–the first effective...
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Immunoglobulin Replacement Therapy Versus Antibiotic Prophylaxis as Treatment for Incomplete Primary Antibody Deficiency
BackgroundPatients with an IgG subclass deficiency (IgSD) ± specific polysaccharide antibody deficiency (SPAD) often present with recurrent...
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Comparison between culture-positive and culture-negative septic shock in patients in the emergency department
Culture results of patients with septic shock affect their management strategies, including antibiotic administration. This study aimed to compare...
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The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C
BackgroundArginine auxotrophy constitutes a shortcoming for ~ 30% of glioblastoma multiforme (GBM). Indeed, arginine-depleting therapy using arginine...
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Gentamicin Dosing in Neonates with Normal Renal Function: Trough and Peak Levels
Background and ObjectiveGentamicin is commonly used in neonates, and it requires drug concentration monitoring. The objective of this study was to...
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Efficacy of adding levofloxacin to gemcitabine and nanoparticle-albumin-binding paclitaxel combination therapy in patients with advanced pancreatic cancer: study protocol for a multicenter, randomized phase 2 trial (T-CORE2201)
BackgroundAdvanced pancreatic cancer is one of the leading causes of cancer-related deaths. For patients with advanced pancreatic cancer, gemcitabine...
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Use of Nanoparticles in Multidrug Resistant Tuberculosis Diagnosis
Tuberculosis (TB) is one of the main community health concerns causing millions of death every year globally. The irrational use of anti-tuberculosis...
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Futuristic Potential of Nanoantibiotics Against Multidrug Resistant Tuberculosis
Tuberculosis (TB) has been a worldwide health issue from the start of sixteenth as well as seventeeth centuries till the date, with new resistance...
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The effect of an antibiotic stewardship program on tigecycline use in a Tertiary Care Hospital, an intervention study
BackgroundA drug-oriented antibiotic stewardship intervention targeting tigecycline utilization was launched at Makassed General Hospital, Beirut,...
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Current Progress and Prospects for a Buruli Ulcer Vaccine
Buruli ulcer (BU), one of the skin-related neglected tropical diseases (skin NTDs), is a necrotizing and disabling cutaneous disease caused by...
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Fecal Microbiota Transplantation in Diseases Not Associated with Clostridium difficile: Current Status and Future Therapeutic Option
Fecal microbiota transplantation (FMT) is one of several effective methods for modifying altered intestinal microbiota and treating certain...
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Successful use of dalbavancin in the treatment of gram positive blood stream infections: a case series
BackgroundDalbavancin is a semisynthetic antibiotic used as an alternative to vancomycin for skin infections and osteomyelitis. Its long half-life...
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Ceftolozane/tazobactam for the treatment of bacteremia: a systematic literature review (SLR)
BackgroundBloodstream infections (BSIs), or bacteremia, are responsible for considerable disease burden. Increasing rates of antibiotic resistance...
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Randomized and dose-escalation trials of recombinant human serum albumin /granulocyte colony-stimulating factor in patients with breast cancer receiving anthracycline-containing chemotherapy
BackgroundTo evaluate the efficacy and safety of recombinant human serum albumin /granulocyte colony-stimulating factor (rHSA/G-CSF) in breast cancer...
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Current Reserve Drugs
The incidence of resistance development against antimicrobial agents is increasing in Gram-negative bacteria (GNB) worldwide. This has resulted into...
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New Anti-tuberculous Drugs: Bedaquiline, Delamanid, and Pretomanid
Development of new drugs to treat drug-resistant tuberculosis is most important in the fight against the global spread of this contagious and...