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Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension
Myeloid cells, such as neutrophils, are produced in the bone marrow in high quantities and are important in the pathogenesis of vascular diseases...
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Virus infection induced pulmonary fibrosis
Pulmonary fibrosis is the end stage of a broad range of heterogeneous interstitial lung diseases and more than 200 factors contribute to it. In...
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Patient-specific finite element analysis of heart failure and the impact of surgical intervention in pulmonary hypertension secondary to mitral valve disease
Pulmonary hypertension (PH), a chronic and complex medical condition affecting 1% of the global population, requires clinical evaluation of right...
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Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation
Cerebral vascular injury as a consequence of blast-induced traumatic brain injury is primarily the result of blast wave-induced mechanical...
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Longitudinal Evolution of Pulmonary Artery Wall Shear Stress in a Swine Model of Pulmonary Artery Stenosis and Stent Interventions
Branch pulmonary artery stenosis (PAS) commonly occurs in congenital heart disease and it has previously been hypothesized that in branch PAS the...
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Neural Crest
This chapter discusses the role of cardiac neural crest cells in the formation of the septum that divides the cardiac arterial pole into separate...
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Depolarization of the Atrial Subepicardium in Rats with Experimentally Induced Pulmonary Hypertension
Using an experimental model of pulmonary hypertension in rats (monocrotaline in a dose of 60 mg/kg), we revealed an additional focus of early...
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Overview on Interactive Role of Inflammation, Reactive Oxygen Species, and Calcium Signaling in Asthma, COPD, and Pulmonary Hypertension
Inflammatory signaling is a major component in the development and progression of many lung diseases, including asthma, chronic obstructive pulmonary...
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Effects of FW2 Nanoparticles Toxicity in a New In Vitro Pulmonary Vascular Cells Model Mimicking Endothelial Dysfunction
Several epidemiological studies have revealed the involvement of nanoparticles (NPs) in respiratory and cardiovascular mortality. In this work, the...
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Exploring the involvement of TASK-1 in the control of isolated rat right atrium function from healthy animals and an experimental model of monocrotaline-induced pulmonary hypertension
The TASK-1 channel belongs to the two-pore domain potassium channel family. It is expressed in several cells of the heart, including the right atrial...
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The Role of the Gene–Gene and Gene–Environment Interactions of Polymorphic Loci of Matrix Metalloproteinases in Forming the Risk of Ischemic Stroke on the Background of Arterial Hypertension in Men
Objectives. To analyze the role of genetic polymorphisms of matrix metalloproteinase ( MMP ) genes and their gene–gene and gene–environment...
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Innate Immune Responses and Pulmonary Diseases
Innate immunity is the first defense line of the host against various infectious pathogens, environmental insults, and other stimuli causing cell...
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Renin Angiotensin System in the Maturation and Failure of Arterio-Venous Fistula
An arteriovenous fistulaArteriovenous fistula (AVF) is the most used vascular access for hemodialysis but is associated with failure occurring within...
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Targeting Molecular and Cellular Mechanisms in Pulmonary Hypertension
Pulmonary hypertension (PH) is described as an elevated mean pulmonary artery pressure (mPAP) of 25 mmHg or above, measured at rest by right-heart...
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Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide...
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Pulmonary Hypertension in Patients with Common Variable Immunodeficiency
PurposeCommon variable immunodeficiency (CVID) is known to cause infectious, inflammatory, and autoimmune manifestations. Pulmonary hypertension (PH)...
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Roles of Genetic Predisposition in the Sex Bias of Pulmonary Pathophysiology, as a Function of Estrogens
In addition to studies focused on estrogen mediation of sex-different regulation of systemic circulations, there is now increasing clinical relevance...
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Role of β3-Adrenoceptor Activation in Changes of Pulmonary Microhemodynamics after Experimental Pulmonary Thromboembolism
Changes in pulmonary microhemodynamics during modelling of pulmonary thromboembolism against the background of nebivolol and mirabegron pretreatment...
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Molecular Pathways and Animal Models of Semilunar Valve and Aortic Arch Anomalies
The great arteries of the vertebrate carry blood from the heart to the systemic circulation and are derived from the pharyngeal arch arteries. In...
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Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats
Chemerin is an adipocytokine having cardiovascular effects. Chemokine-like receptor 1 (CMKLR1) and chemokine (CC motif) receptor-like 2 (CCRL2) are...
