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The embodiment of the strategy of “using active chemicals as excipients” in compound preparation
Background“Using active chemicals as excipients” refers to a preparation strategy. It makes use of the drugs owning the special physical and chemical...
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Advances in photobiomodulation for cognitive improvement by near-infrared derived multiple strategies
Cognitive function is an important ability of the brain, but cognitive dysfunction can easily develop once the brain is injured in various...
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Phytochemicals targeting NAFLD through modulating the dual function of forkhead box O1 (FOXO1) transcription factor signaling pathways
AbstractLiterature evidence reveals that natural compounds are potential candidates for ameliorating obesity-associated non-alcoholic fatty liver...
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Experimental Protocols in Phytochemistry and Natural Products: An Ever-Evolving Challenge
Natural products have been an important source of drugs for the past few centuries. Extraction and isolation of natural products involve extensive...
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Interaction of NF-κB and Wnt/β-catenin Signaling Pathways in Alzheimer’s Disease and Potential Active Drug Treatments
The most important neuropathological features of Alzheimer's disease (AD) are extracellular amyloid-β protein (Aβ) deposition, tau protein...
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Targeting P2 receptors in purinergic signaling: a new strategy of active ingredients in traditional Chinese herbals for diseases treatment
Adenosine triphosphate (ATP) and its metabolites adenosine diphosphate, adenosine monophosphate, and adenosine in purinergic signaling pathway play...
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Reversal of Metabolic Disorder Through the Restoration of Gut Microbiota
Dysbiosis is a condition in which the makeup of the gut microbiota varies as a result of food habits and lifestyle changes caused by external or...
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Matrine Alleviates Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis and Apoptosis
Matrine is a Sophora alkaloid that exerts antitumor effects on a variety of diseases, but few studies have investigated the role of matrine in...
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Co-amorphous Drug Delivery Systems: a Review of Physical Stability, In Vitro and In Vivo Performance
Over the past few decades, co-amorphous solids have been used as a promising approach for delivering poorly water-soluble drugs. Co-amorphous solids,...
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A critical overview of challenging roles of medicinal plants in improvement of wound healing technology
PurposeChronic diseases often hinder the natural healing process, making wound infections a prevalent clinical concern. In severe cases,...
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Gentiopicroside inhibits retinoblastoma cell proliferation, invasion, and tumorigenesis in nude mice by suppressing the PI3K/AKT pathway
Retinoblastoma is a prevalent pediatric intraocular tumor. The suppressive effect of gentiopicroside (GPS) has been reported on various tumors. This...
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Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics
Atherosclerosis, one of the life-threatening cardiovascular diseases (CVDs), has been demonstrated to be a chronic inflammatory disease, and...
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Hederagenin protects against myocardial ischemia–reperfusion injury via attenuating ALOX5-mediated ferroptosis
Hederagenin (HDG), a medical herb, is known for its beneficial activities against diverse diseases. The cardioprotective effect of HDG has been...
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Natural products: potential treatments for cisplatin-induced nephrotoxicity
Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and...
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Alternative Therapies for Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect caused by many antineoplastic drugs. Currently, there are no FDA-approved...
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Mitochondria-Related Gene MAOB is a Key Biomarker of Osteoarthritis and Inhibition of Its Expression Reduces LPS-induced Chondrocyte Damage
The mitochondria are an important organelle in cells responsible for producing energy, and its abnormal function is closely related to the occurrence...
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Puerarin-7-O-glucuronide, a water-soluble puerarin metabolite, prevents angiotensin II-induced cardiomyocyte hypertrophy by reducing oxidative stress
This study aimed to investigate the anti-oxidant and anti-hypertrophic effects of puerarin-7- O -glucuronide, a water-soluble puerarin metabolite. The...
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Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) accounts for 5% of all stroke cases and is responsible for significant permanent brain and neurological damage within...
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An Overview of Hypoglycemic Traditional Drugs
Folk or traditional systems of medicines always played an indispensable role in the global healthcare system. Traditional medicine as abundant...
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Phytochemicals and Natural Extracts, Secondary Metabolites of Plants and Improvement of Brain Function
Memory, one of the most enhanced functions of human being, proclaims an activity-dependent synaptic plasticity at various synaptic levels in the...