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Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation
Signaling by insulin-like growth factor-1 (IGF-1) is essential for the development of the central nervous system (CNS) and regulates neuronal...
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Genetically Encoded Reporters to Monitor Hypoxia
Hypoxia resulting from an imbalance of oxygen availability and consumption defines a metabolic cellular state with a profound impact on developmental...
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Two Photon Fluorescence Lifetime Imaging of Reduced Nicotinamide Adenine Dinucleotide in Brain Research
Current understanding of the structure and functions of the brain is inadequate to explain the complex neurobiological phenomenon associated with the...
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Discovery and Development of Tumor Angiogenesis Assays
The angiogenesis process was described in its basic concepts in the works of the Scottish surgeon John Hunter and terminologically assessed in the...
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Intravital Microscopy in the Mouse Lung
While reductionist in vitro approaches have allowed for careful interrogation of cellular pathways that underlie innate immune responses, they often...
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Pre-hyperglycemia immune cell trafficking underlies subclinical diabetic cataractogenesis
BackgroundThis work elucidates the first cellular and molecular causes of cataractogenesis. Current paradigm presupposes elevated blood glucose as a...
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Oral methylmercury intoxication aggravates cardiovascular risk factors and accelerates atherosclerosis lesion development in ApoE knockout and C57BL/6 mice
Methylmercury (MeHg) intoxication is associated with hypertension, hypercholesterolemia, and atherosclerosis by mechanisms that are not yet fully...
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Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke
BackgroundStroke remains one of the leading causes of long-term disability worldwide, and the development of effective restorative therapies is...
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Multi-feature-Based Robust Cell Tracking
Cell tracking algorithms have been used to extract cell counts and motility information from time-lapse images of migrating cells. However, these...
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Subcellular Drug Depots as Reservoirs for Small-Molecule Drugs
Therapeutic nanoparticles (TNP) have been developed to more efficiently and safely deliver medicines, especially for the treatment of solid cancers....
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The localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent
BackgroundHow platelets interact with and influence the tumor microenvironment (TME) remains poorly characterized.
MethodsWe compared the presence...
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Live Imaging of Mitochondria in Kidney Tissue
Kidneys are highly aerobic organs and their function is tightly coupled to mitochondrial energy production. Renal tubular cells, particularly the...
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Assessment of Endothelial Barrier Functions in Extra Embryonic Vasculature of Chick Embryo as an Alternative Model
Vascular permeability, a tightly regulated process, is a direct measure of angiogenic and immune responses in the endothelium altered in several...
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In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy
The detection of amyloid beta deposits and neurofibrillary tangles, both hallmarks of Alzheimer’s disease (AD), is key to understanding the...
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Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer
BackgroundLimited understanding of the cancer biology of metastatic sites is a major factor contributing to poor outcomes in cancer patients. The...
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Optogenetic stimulation of basal forebrain cholinergic neurons prevents neuroinflammation and neuropsychiatric manifestations in pristane induced lupus mice
BackgroundNeuroinflammation has been identified as one of the primary pathogenic factors of neuropsychiatric systemic lupus erythematosus (NPSLE)....
