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Computers in Clinical Development
Clinical development of a pharmaceutical product plays an important role as it regulates the future of investigational new drug application approval...
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PARP inhibition with rucaparib alone followed by combination with atezolizumab: Phase Ib COUPLET clinical study in advanced gynaecological and triple-negative breast cancers
BackgroundCombining PARP inhibitors (PARPis) with immune checkpoint inhibitors may improve clinical outcomes in selected cancers. We evaluated...
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Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a rare, adult-onset neurodegenerative movement disorder occurring in some carriers of a 55–200...
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Clinical and functional determinants of appropriate rehabilitation referrals after stroke: a single-center retrospective cohort study
BackgroundRehabilitation is currently the best available treatment for post-stroke disability. There is, however, great variability in the proportion...
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Ethics of Clinical Research
There have been horrendous episodes in history, in which physicians actively participated in horrendous crimes against humanity. Racism, and the...
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Phenomenological Evaluation of an Undergraduate Clinical Needs Finding Skills Through a Virtual Reality Clinical Immersion Platform
Clinical immersion programs have been widely used in higher education, particularly in biomedical engineering (BME) programs, to allow students to...
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Cell-Based Therapies in Clinical Pain Management
Development of novel therapies is required to transform care for chronic and refractory pain due to degenerative and neuropathic conditions....
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Transcatheter Pulmonary Artery Banding in High-Risk Neonates: In-Vitro Study Provoked by Initial Clinical Experience
PurposeVery high-risk, ductal-dependent or complex two-ventricle patients with associated comorbidities often require pulmonary blood flow...
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Safety and efficacy of pyronaridine–artesunate paediatric granules in the treatment of uncomplicated malaria in children: insights from randomized clinical trials and a real-world study
BackgroundChildren are particularly at risk of malaria. This analysis consolidates the clinical data for pyronaridine–artesunate (PA) paediatric...
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Impact of metronomic trabectedin combined with low-dose cyclophosphamide on sarcoma microenvironment and correlation with clinical outcome: results from the TARMIC study
Soft tissue sarcomas (STS) are diverse mesenchymal tumors with few therapeutic options in advanced stages. Trabectedin has global approval for...
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Statistical study of clinical trials with stem cells and their function in skin wound
Mesenchymal stem cells (MSCs) have been known as a reliable and effective source to repair damaged tissues. The differentiation and self-renewal...
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Viral Immunotherapy Strategies in Clinical Practice
Viruses are a tool that can be used to help activate the immune system against cancer. Viral genetics may be changed to make a virus less infectious...
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Clinical applications of telemedicine services using a regional telemedicine platform for cancer treatment: a cross-sectional study
BackgroundTelemedicine is beneficial for improving treatment efficiency and reducing medical expenses of cancer patients. This study focuses on...
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Efficacy and safety of fluzoparib combined with anlotinib in extensive stage small cell lung cancer after first-line platinum-based chemotherapy: a multi-center, single-arm prospective phase II clinical study (STAMP study)
BackgroundSmall-cell lung cancer (SCLC) is a highly aggressive and lethal malignancy that accounts for 10–15% of lung cancers, and it is generally...
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Clinical Applications of 3D Printed Drug Products
Common challenges in pharmaceutical formulation development and clinical manufacturing include manual labor and a lack of flexibility to formulate a...
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Oligo-metastatic neoPlasms from the gastro-intestinal tract: iDentIfiCaTIon of cliNical and molecular drivers: the PREDICTION study
BackgroundMetastatic disease in tumors originating from the gastrointestinal tract can exhibit varying degrees of tumor burden at presentation. Some...
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Clinical pilot study for EPID-based in vivo dosimetry using EPIgray™ for head and neck VMAT
This work details the clinical pilot study methodology used at Wellington Blood and Cancer Centre (WBCC) before the clinical release of in vivo...
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Good Clinical Practice in Clinical Trials, Substantial Evidence of Efficacy, and Interpretation of the Evidence
Sponsors seeking marketing authorization for a drug in the United States of America are required to demonstrate substantial evidence of effectiveness...
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Heterogeneity of clinical symptomatology in pediatric patients at clinical high risk for psychosis
ObjectiveWidespread use of diagnostic tools like the Structured Interview for Prodromal Symptoms (SIPS) has highlighted that youth at Clinical High...
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Clinical and molecular features of NDM-producing Acinetobacter baumannii in a multicenter study in Israel
BackgroundNDM-producing Acinetobacter baumannii (NDMAb) were reported sporadically worldwide but little is known about the transmission,...
