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Computational Assessment of Valvular Dysfunction in Discrete Subaortic Stenosis: A Parametric Study
PurposeDiscrete subaortic stenosis (DSS) is a left-ventricular outflow tract (LVOT) obstruction caused by a membranous lesion. DSS is associated with...
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Population pharmacokinetic analysis and dosage recommendations for digoxin in Japanese patients with atrial fibrillation and heart failure using real-world data
BackgroundDigoxin is an important treatment option for reducing the ventricular rate in patients with atrial fibrillation (AF) and heart failure...
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The impact of the COVID-19 pandemic on cardiovascular disease prevention and management
How the Coronavirus Disease 2019 (COVID-19) pandemic has affected prevention and management of cardiovascular disease (CVD) is not fully understood....
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Heart atlas for retrospective cardiac dosimetry: a multi-institutional study on interobserver contouring variations and their dosimetric impact
PurposeCardiac effects after breast cancer radiation therapy potentially affect more patients as survival improves. The heart’s heterogeneous...
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The Critical Biomechanics of Aortomitral Angle and Systolic Anterior Motion: Engineering Native Ex Vivo Simulation
Systolic anterior motion (SAM) of the mitral valve (MV) is a complex pathological phenomenon often occurring as an iatrogenic effect of surgical and...
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Rationale and design of interleukin-1 blockade in recently decompensated heart failure (REDHART2): a randomized, double blind, placebo controlled, single center, phase 2 study
BackgroundHeart failure (HF) is a global leading cause of mortality despite implementation of guideline directed therapy which warrants a need for...
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Heart disease in pregnancy—clinical pattern and prevalence: initial data from the first cardio-maternal unit in Iraq
ObjectivesThe purpose of this study to determine the clinical pattern and prevalence of heart disease in pregnancy at the first established...
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Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats
RationaleCabergoline (CAB) is an ergot derivative typically prescribed for the treatment of hyperprolactinemia. It suppresses the release of...
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Adjuvant postmastectomy radiotherapy might be associated with better survival in women with heart failure receiving total mastectomy
BackgroundTo date, no data on the effect of adjuvant postmastectomy radiotherapy (PMRT) on oncologic outcomes, such as all-cause death, locoregional...
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A Novel Transcatheter Device for the Edge-to-Edge Treatment of Tricuspid Regurgitation: A Preliminary Evaluation
Tricuspid regurgitation (TR) is the most common pathology of the tricuspid valve (TV), with significant mortality in severe cases. A well-established...
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Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson’s disease brains
Gingipains are protease virulence factors produced by Porphyromonas gingivalis , a Gram-negative bacterium best known for its role in chronic...
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Biomechanical Evaluation of Aortic Valve Stenosis by Means of a Virtual Stress Test: A Fluid–Structure Interaction Study
The impact of aortic valve stenosis (AS) extends beyond the vicinity of the narrowed leaflets into the left ventricle (LV) and into the systemic...
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The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration
Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart valves but their susceptibility to structural valve...
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5-HT2B Receptor in Cardiopulmonary Disease
Cardiopulmonary disease is driven by a plethora of factors, some well characterized and others still undiscovered. The 5-HT2B serotonin receptor...
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Establishing the Biofidelity of a Multiphysics Finite Element Model of the Human Heart
PurposeAccelerating development of new therapeutic cardiac devices remains a clinical and technical priority. High-performance computing and the...
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Analysis of lncRNA-miRNA-mRNA expression pattern in heart tissue after total body radiation in a mouse model
BackgroundRadiation therapy is integral to effective thoracic cancer treatments, but its application is limited by sensitivity of critical organs...
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Effect of heart rate control with amiodarone infusion on hemodynamic and clinical outcomes in septic shock patients with tachycardia: a prospective, single-arm clinical study
BackgroundKee** the heart rate within the normal range has improved the survival of septic shock patients. Amiodarone could target the underlying...
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Ex Vivo Model of Ischemic Mitral Regurgitation and Analysis of Adjunctive Papillary Muscle Repair
Ischemic mitral regurgitation (IMR) is particularly challenging to repair with lasting durability due to the complex valvular and subvalvular...
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Advanced glycosylation end products promote the progression of CKD-MBD in rats, and its natural inhibitor, quercetin, mitigates disease progression
Chronic kidney disease–mineral and bone metabolism disorder (CKD-MBD) is a common chronic kidney disease (CKD)-associated complication that increases...
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Identification of key genes in calcific aortic valve disease via weighted gene co-expression network analysis
BackgroundCalcific aortic valve disease (CAVD) is the most common subclass of valve heart disease in the elderly population and a primary cause of...
