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Mediation Analysis of Microbiome Data and Detection of Causality in Microbiome Studies
Microbiome research has basically focused on three factors: environment, microbiome, and host. The interactions among these three factors are dynamic...
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The Interleukin-6 gene variants may protect against SARS-CoV-2 infection and the severity of COVID-19: a case-control study in a Moroccan population
The symptoms of SARS-CoV-2 infection vary widely, ranging from asymptomatic cases to severe forms marked by acute respiratory distress syndrome,...
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Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial
Patients with rheumatoid arthritis (RA) receive highly targeted biologic therapies without previous knowledge of target expression levels in the...
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Motives for withdrawal of participation in biobanking and participants’ willingness to allow linkages of their data
Data repositories, like research biobanks, seek to optimise the number of responding participants while simultaneously attempting to increase the...
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Sphingolipids: A Roadmap from Biomarker Identification to Clinical Application
Sphingolipids are a class of bioactive lipids that have recently gained paramount attention in the field of cancer biology. Sphingolipid metabolism...
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Machine learning-derived identification of tumor-infiltrating immune cell-related signature for improving prognosis and immunotherapy responses in patients with skin cutaneous melanoma
BackgroundImmunoblockade therapy based on the PD-1 checkpoint has greatly improved the survival rate of patients with skin cutaneous melanoma (SKCM)....
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A systematic analysis of gene–gene interaction in multiple sclerosis
BackgroundFor the most part, genome-wide association studies (GWAS) have only partially explained the heritability of complex diseases. One of their...
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ZEB family is a prognostic biomarker and correlates with anoikis and immune infiltration in kidney renal clear cell carcinoma
BackgroundZinc finger E-box binding homEeobox 1 (ZEB1) and ZEB2 are two anoikis-related transcription factors. The mRNA expressions of these two...
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Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study
BackgroundThis study investigated the effect of sex and age at type 2 diabetes (T2D) diagnosis on the influence of T2D-related genes, parental...
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HLA-DQA1*05 and upstream variants of PPARGC1B are associated with infliximab persistence in Japanese Crohn’s disease patients
Recently, the HLA-DQA1*05 (rs2097432) genetic variation has been reported to be linked to early infliximab (IFX) treatment failure in the Caucasian...
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Polymorphism at codon 31 of CDKN1A (p21) as a predictive factor for bevacizumab therapy in glioblastoma multiforme
Glioblastoma (GBM), a prevalent and malignant brain tumor, poses a challenge in surgical resection due to its invasive nature within the brain...
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RIPK1 polymorphisms and expression levels: impact on genetic susceptibility and clinical outcome of epithelial ovarian cancer
BackgroundThe aim of this study was to explore the associations of RIPK1 polymorphisms, plasma levels and mRNA expression with susceptibility to...
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Construction of iron metabolism-related prognostic features of gastric cancer based on RNA sequencing and TCGA database
BackgroundResearches have manifested that the disorder of iron metabolism is participated in Gastric cancer (GC), but whether iron...
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Immune landscape of periodontitis unveils alterations of infiltrating immunocytes and molecular networks-aggregating into an interactive web-tool for periodontitis related immune analysis and visualization
BackgroundImmunity reaction plays an essential role in periodontitis progress and we aim to investigate the underlying regulatory network of immune...
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Causal relationship between gut Prevotellaceae and risk of sepsis: a two-sample Mendelian randomization and clinical retrospective study in the framework of predictive, preventive, and personalized medicine
ObjectiveGut microbiota is closely related to sepsis. Recent studies have suggested that Prevotellaceae could be associated with intestinal...
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Eyecare-cloud: an innovative electronic medical record cloud platform for pediatric research and clinical care
Background and objectivesClinical data are essential for develo** cloud platforms for intelligent diagnosis and treatment decision of diseases....
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QTL Analysis
Most of the important agronomic traits are quantitatively inherited and are controlled by several genes (i.e., polygenic). The nature of quantitative...
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Immunologic constant of rejection as a predictive biomarker of immune checkpoint inhibitors efficacy in non-small cell lung cancer
BackgroundAnti-PD1/PDL1 immune checkpoint inhibitors (ICI) transformed the prognosis of patients with advanced non-small cell lung cancer (NSCLC)....
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Lung cancer multi-omics digital human avatars for integrating precision medicine into clinical practice: the LANTERN study
BackgroundThe current management of lung cancer patients has reached a high level of complexity. Indeed, besides the traditional clinical variables...
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Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide...
