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Histological study of the role of CD34+ stem cells and mast cells in cyclophosphamide-induced thymic injury in rats and the possible attenuating role of melatonin
Cyclophosphamide (CP) is an anticancer drug that adversely affects immunity and thymus structure. Melatonin is a hormone secreted by the pineal...
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Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies
Autophagy is an essential cellular homeostasis pathway initiated by multiple stimuli ranging from nutrient deprivation to viral infection, playing a...
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Thymic self-antigen expression for immune tolerance and surveillance
T cells are a group of lymphocytes that play a central role in the immune system, notably, eliminating pathogens and attacking cancer while being...
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Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus
T cell specificity and function are linked during development, as MHC-II-specific TCR signals generate CD4 helper T cells and MHC-I-specific TCR...
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Microbial ligand-independent regulation of lymphopoiesis by NOD1
Aberrant differentiation of progenitor cells in the hematopoietic system is known to severely impact host immune responsiveness. Here we demonstrate...
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Genetic Tools for Analyzing Foxp3+ Treg Cells: Fluorochrome-Based Transcriptional Reporters and Genetic Fate-Map**
The lack of unambiguous Foxp3+ Treg cell–specific surface markers has prompted the development of various transgenic mouse lines with Foxp3-dependent...
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A single dose of angiotensin-(1–7) resolves eosinophilic inflammation and protects the lungs from a secondary inflammatory challenge
ObjectiveAngiotensin-(1–7) [Ang-(1–7)] is a pro-resolving mediator. It is not known whether the pro-resolving effects of Ang-(1–7) are sustained and...
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Themis suppresses the effector function of CD8+ T cells in acute viral infection
CD8 + T cells play a central role in antiviral immune responses. Upon infection, naive CD8 + T cells differentiate into effector cells to eliminate...
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Epigenetic reprogramming of T cells: unlocking new avenues for cancer immunotherapy
T cells, a key component of cancer immunotherapy, undergo a variety of histone modifications and DNA methylation changes since their bone marrow...
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TCF-1: a maverick in T cell development and function
The T cell-specific DNA-binding protein TCF-1 is a central regulator of T cell development and function along multiple stages and lineages. Because...
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BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity
Myeloid epithelial reproductive proto-oncogene tyrosine kinase (MERTK) plays an essential role in modulating cancer immune tolerance by regulating...
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Molecular mechanisms of lineage decisions in metabolite-specific T cells
Mucosal-associated invariant T cells (MAIT cells) recognize the microbial metabolite 5-(2-oxopropylideneamino)-6- d -ribitylaminouracil (5-OP-RU)...
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The P2X7 receptor in mucosal adaptive immunity
The P2X7 receptor (P2X7R) is a widely distributed cation channel activated by extracellular ATP (eATP) with exclusive peculiarities with respect to...
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Development of αβ T Cells with Innate Functions
Although we mostly think of αβ T cells as components of the adaptive immune system, a number of them differentiate into alternative lineages. These...