Search
Search Results
-
A computational approach to design a multiepitope vaccine against H5N1 virus
Since 1997, highly pathogenic avian influenza viruses, such as H5N1, have been recognized as a possible pandemic hazard to men and the...
-
Q fever immunology: the quest for a safe and effective vaccine
Q fever is an infectious zoonotic disease, caused by the Gram-negative bacterium Coxiella burnetii . Transmission occurs from livestock to humans...
-
In silico analysis of virulence factors of Streptococcus uberis for a chimeric vaccine design
Streptococcus uberis is one of the causative agents of bovine mastitis, which has detrimental effects on animal health and the dairy industry....
-
Intranasal vaccination with an NDV-vectored SARS-CoV-2 vaccine protects against Delta and Omicron challenges
The rapid development and deployment of vaccines following the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been...
-
Pan-genome and reverse vaccinology approaches to design multi-epitope vaccine against Epstein-Barr virus associated with colorectal cancer
AbstractEpstein-Barr virus (EBV) is a global lymphotropic virus and has been associated with various malignancies, among which colorectal cancer...
-
A dual-antigen malaria vaccine targeting Pb22 and Pbg37 was able to induce robust transmission-blocking activity
BackgroundDespite years of effort to develop an effective vaccine against malaria infection, a vaccine that provides individuals with sufficient...
-
Polymeric epitope-based vaccine induces protective immunity against group A Streptococcus
Group A Streptococcus (Strep A) is a life-threatening human pathogen with no licensed vaccine. Here, we used a biopolymer particle (BP) approach to...
-
Strategies to reduce the risks of mRNA drug and vaccine toxicity
mRNA formulated with lipid nanoparticles is a transformative technology that has enabled the rapid development and administration of billions of...
-
Integrating core subtractive proteomics and reverse vaccinology for multi-epitope vaccine design against Rickettsia prowazekii endemic typhus
Rickettsia prowazekii is an intracellular, obligate, gram-negative coccobacillus responsible for epidemic typhus. Usually, the infected body louse or...
-
Immunogenicity phase II study evaluating booster capacity of nonadjuvanted AKS-452 SARS-Cov-2 RBD Fc vaccine
AKS-452, a subunit vaccine comprising an Fc fusion of the ancestral wild-type (WT) SARS-CoV-2 virus spike protein receptor binding domain (SP/RBD),...
-
A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression
Here we report on the development and comprehensive evaluations of an mRNA vaccine for chronic hepatitis B (CHB) treatment. In two different HBV...
-
OpcA and PorB are novel bactericidal antigens of the 4CMenB vaccine in mice and humans
The ability of Neisseria meningitidis Outer Membrane Vesicles (OMV) to induce protective responses in humans is well established and mainly...
-
Immunogenicity and protective activity of mRNA vaccine candidates against yellow fever virus in animal models
Despite the success of the widely used attenuated yellow fever (YF) vaccine, its global supply remains a substantial barrier to implementing...
-
Vaccines and Immunoinformatics for Vaccine Design
The host immune system recognizes and responds to the selective antigens or epitopes (immunome) of the intruding pathogen over an entire organism....
-
Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection
A nasally delivered chimpanzee adenoviral-vectored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (ChAd-SARS-CoV-2-S) is...
-
A report on neurogenic bladder in COVID-19 vaccine-associated acute transverse myelitis
IntroductionAcute transverse myelitis (ATM) is a rare neurological complication of Coronavirus disease (COVID-19) vaccines. Various vaccines have...
-
Antigen identification strategies and preclinical evaluation models for advancing tuberculosis vaccine development
In its myriad devastating forms, Tuberculosis (TB) has existed for centuries, and humanity is still affected by it. Mycobacterium tuberculosis ( M....
-
Calcifediol boosts efficacy of ChAdOx1 nCoV-19 vaccine by upregulating genes promoting memory T cell responses
The ChAdOx1 nCoV-19 (COVISHIELD) vaccine has emerged as a pivotal tool in the global fight against the COVID-19 pandemic. In our previous study...
-
Potent and long-lasting humoral and cellular immunity against varicella zoster virus induced by mRNA-LNP vaccine
Varicella zoster virus (VZV) is a highly contagious human herpes virus responsible for causing chickenpox (varicella) and shingles (herpes zoster)....
-
Screening of immunogenic proteins and evaluation of vaccine candidates against Mycoplasma synoviae
Mycoplasma synoviae ( M. synoviae ) is a serious avian pathogen that causes significant economic losses to chicken and turkey producers worldwide. The...
