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Predictive genomic tools in disease stratification and targeted prevention: a recent update in personalized therapy advancements
In the current era of medical revolution, genomic testing has guided the healthcare fraternity to develop predictive, preventive, and personalized...
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Mobilization of endothelial progenitor cells in sepsis
PurposeSepsis, an intractable clinical syndrome, is often accompanied by severe vascular endothelial injury and barrier dysfunction. Previous...
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Use of the French healthcare insurance database to estimate the prevalence of exposure to potential drug-drug interactions
PurposeDrug-drug interactions (DDIs) require monitoring in an aging population with increasing polypharmacy exposure. We aimed to estimate the...
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Dried Blood Spots—A Platform for Therapeutic Drug Monitoring (TDM) and Drug/Disease Response Monitoring (DRM)
This review provides an overview on the current applications of dried blood spots (DBS) as matrices for therapeutic drug (TDM) and drug or disease...
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Introduction to Drugs, Drug Targets and Drug Resistance
Drugs are the moieties used in treating diseases. Drugs include vaccines, antidepressants, antibiotics, antiviral, anesthetics, stimulants, and...
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Mechanisms of Heart Failure
Heart failure (HF) is an end-stage manifestation of various heart diseases and a major cause of death in patients with heart disease. Morbidity...
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Clinical Trials for Motor Complications in Parkinson’s Disease
The development of motor fluctuations with the dopaminergic treatment response together with treatment-associated dyskinesia is inevitable in...
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Brain Renin–Angiotensin System Blockade Attenuates Methamphetamine-Induced Hyperlocomotion and Neurotoxicity
Methamphetamine (METH) abuse has become a major public health concern worldwide without approved pharmacotherapies. The brain renin–angiotensin...
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What should patients do if they miss a dose? A systematic review of patient information leaflets and summaries of product characteristics
PurposeMedicines regulatory authorities advise that patient information leaflets (PILs) should provide specific advice on what actions to take if one...
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The Renin Angiotensin System as a Therapeutic Target in Traumatic Brain Injury
Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological options available beyond symptomatic relief. The renin...
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The Importance of Drug Dose Adjustment in Elderly Patients with Special Considerations for Patients on Diverse Co-medications and Antidepressants
The geriatric population is escalating globally, and the need for treating infectious and non-infectious diseases in elderly patients is also...
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Rodent Models of Vascular Cognitive Impairment
Vascular cognitive impairment (VCI) refers to the entire spectrum of vascular brain pathologies that contribute to cognitive deficits, ranging from...
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Advanced bioinformatics rapidly identifies existing therapeutics for patients with coronavirus disease-2019 (COVID-19)
BackgroundThe recent global pandemic has placed a high priority on identifying drugs to prevent or lessen clinical infection of severe acute...
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Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer
A large body of evidence indicates the existence of a complex pathophysiological relationship between cardiovascular diseases and cancer....
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Molecular Profiling of Breast Cancer in Clinical Trials: A Perspective
Breast cancer molecular profiling is a fundamental criterion to identify novel molecular targets and determine pertinent treatment options....
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Drugs Resistance in Heart Diseases
Heart is a vital blood pum** organ of human body. Cholesterol buildup, smoking, obesity and high blood pressure causes heart malfunctioning leading...
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Percutaneous Delivery of Antihypertensive Agents: Advances and Challenges
Hypertension remains a significant risk factor for several cardiovascular disorders including coronary artery disease and heart failure. Despite the...
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The Toxicology Investigators Consortium Case Registry—the 2021 Annual Report
The Toxicology Investigators Consortium (ToxIC) Core Registry was established by the American College of Medical Toxicology in 2010. The Core...
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Chronopharmacology in Drug Development
The human body is highly organized in time and most functions display significant daily [circadian] and seasonal rhythms. Gene expression in the...