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Contribution of Transglutaminase to the Induction and Maintenance of Long-Term Synaptic Potentiation in Neurons in the Common Snail
Previous studies have shown that the neurotransmitter serotonin is required for the successful formation of long-term potentiation in the terrestrial...
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Functional Regulation Between Matrix Metalloproteases and Cell Junction Proteins in Gastric Cancer
Gastric cancer (GC) is one of the most frequent malignancies of the digestive tract worldwide. The tumor microenvironment plays a key role in the...
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Astragalin attenuates depression-like behaviors and memory deficits and promotes M2 microglia polarization by regulating IL-4R/JAK1/STAT6 signaling pathway in a murine model of perimenopausal depression
RationaleNeuroinflammation can be alleviated via M2 microglia polarization, which could promote the recovery of perimenopausal depression. Astragalin...
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Single-Cell Sequencing Reveals the Expression of Immune-Related Genes in Macrophages of Diabetic Kidney Disease
Diabetic kidney disease (DKD) is characterized by macrophage infiltration, which requires further investigation. This study aims to identify...
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Common hotspots of cancer chemotherapy
Cancer is fundamentally a disturbance in the regulation of tissue development. Normal cells must undergo alterations in the genes responsible for...
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Increased canonical NF-kappaB signaling specifically in macrophages is sufficient to limit tumor progression in syngeneic murine models of ovarian cancer
BackgroundNew treatment options for ovarian cancer are urgently required. Tumor-associated macrophages (TAMs) are an attractive target for therapy;...
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RGS proteins and their roles in cancer: friend or foe?
As negative modulators of G-protein-coupled receptors (GPCRs) signaling, regulators of G protein signaling (RGS) proteins facilitate various...
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The essential roles of FXR in diet and age influenced metabolic changes and liver disease development: a multi-omics study
BackgroundAging and diet are risks for metabolic diseases. Bile acid receptor farnesoid X receptor (FXR) knockout (KO) mice develop metabolic liver...
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Dopamine and L-Dopa as Selective Endogenous Neurotoxins
Selective neurotoxins have the ability to exert their neurotoxic effects in dopaminergic neurons. This could depend on their affinity to the dopamine...
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Heparin-Binding Protein Enhances NF-κB Pathway-Mediated Inflammatory Gene Transcription in M1 Macrophages via Lactate
In early-stage sepsis, glucose metabolism is increased primarily through glycolysis in the inflammatory response of M1 macrophages. Heparin-binding...
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Roles for GADD45 in Development and Cancer
The Growth Arrest and DNA Damage-inducible 45 (GADD45) family of proteins are critical stress sensors that mediate various cellular responses,...
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Dopamine and L-Dopa as Selective Endogenous Neurotoxins
Selective neurotoxins have the ability to exert their neurotoxic effects in dopaminergic neurons. This could depend on their affinity to the dopamine...
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Anti-Inflammatory Molecular Mechanism and Contribution of Drug Transport Molecules in Colorectal Cancer Cells
Colorectal cancer (CRC) is a third most common malignant neoplasm arising from the lining of colon and rectum of the large intestine. The molecular...
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New Data on the Pathophysiology of Ischemic Stroke: Epigenetic Mechanisms in Focus
Epigenetics is a branch of molecular biology studying modifications able to change the expression of genes without altering their DNA sequences....
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The Role of Circular RNAs in Ischemic Stroke
Ischemic stroke (IS), a devastating condition characterized by intracranial artery stenosis and middle cerebral artery occlusion leading to...
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The underlying mechanisms of cisplatin-induced nephrotoxicity and its therapeutic intervention using natural compounds
Cisplatin is an effective chemotherapeutic drug widely used for the treatment of various solid tumors; however, its clinical use and efficacy are...
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Diabetes-induced male infertility: potential mechanisms and treatment options
Male infertility is a physiological phenomenon in which a man is unable to impregnate a fertile woman during a 12-month period of continuous,...
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Is Hypoxic/Altitude Training an Important Topic in the Field of Hypoxia?
Hypoxia is an essential topic in medical or biological sciences. The main aims of the present study were to examine the most important medical...
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Relationship between the thrombospondin-1/Toll-like receptor 4 (TSP1/TLR4) pathway and vitamin D levels in obese and normal weight subjects with different metabolic phenotypes
Thrombospondin-1 (TSP1) contributes to obesity-associated inflammation via activating Toll-like receptor 4 (TLR4). The regulatory role of vitamin D...
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Comprehensive research into prognostic and immune signatures of transcription factor family in breast cancer
BackgroundBreast cancer (BRCA) is the most common malignancy with high morbidity and mortality in women, and transcription factor (TF) is closely...
