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Adenovirus vector-mediated YKL-40 shRNA attenuates eosinophil airway inflammation in a murine asthmatic model
Recent studies have revealed that YKL-40 is involved in the pathogenesis of asthma. However, its specific mechanism remains unclear. The present...
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Drugs Affecting Gastrointestinal Functions
The digestive system in humans is the mechanism that the body uses to carry out digestion. Food is ingested by the digestive system, which is...
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Helicobacter pylori–activated fibroblasts as a silent partner in gastric cancer development
The discovery of Helicobacter pylori ( Hp ) infection of gastric mucosa leading to active chronic gastritis, gastroduodenal ulcers, and MALT lymphoma...
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Macrolides as Immunomodulatory Agents
Diffuse panbronchiolitis (DPB) is a disease characterized by diffuse bilateral centrilobular lesions consisting of peribronchial infiltration of...
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Effects of the Lower Airway Secretions on Airway Opening Pressures and Suction Pressures in Critically Ill COVID-19 Patients: A Computational Simulation
In patients with critically ill COVID-19 pneumonia, lower airways are filled with plenty of highly viscous exudates or mucus, leading to airway...
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Evolution and function of the epithelial cell-specific ER stress sensor IRE1β
Barrier epithelial cells lining the mucosal surfaces of the gastrointestinal and respiratory tracts interface directly with the environment. As such,...
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Markers of Bacterial Translocation in Type 2 Diabetes Mellitus
Type 2 Diabetes mellitus is a multifactorial metabolic disorder. The growing body of evidence linking the gut microbiome to host metabolism has been...
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Plant Immunoenhancers: Promising Ethnopharmacological Candidates for Anti-SARS-CoV-2 Activity
Medicinal plants have gained attention for their bioactive phytochemicals, affordability, patient-friendly nature, and avoidance of synthetic drug...
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Pathophysiology of Allergic Airways Disease
Allergic airways disease, encompassing conditions such as asthma and allergic rhinitis, presents a significant global health burden. This chapter...
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Dopamine and Gastrointestinal Mucosa Function
The mucosa layer of the gastrointestinal (GI) tract maintains structural integrity, which is essential for kee** internal balance of fluids,...
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Targeting purinergic receptors to attenuate inflammation of dry eye
Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that...
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H+/K+-ATPase Inhibitors from Plants: A Potential Source for Drug Discovery
Apart from regulatory biomolecules, namely acetylcholine, histamine, and gastrin that stimulate gastric acid secretions, H+/K+-ATPase also referred...
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TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity
Loss of the colonic inner mucus layer leads to spontaneously severe colitis and colorectal cancer. However, key host factors that may control the...
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Dimethyl itaconate ameliorates cognitive impairment induced by a high-fat diet via the gut-brain axis in mice
BackgroundGut homeostasis, including intestinal immunity and microbiome, is essential for cognitive function via the gut-brain axis. This axis is...
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Liposome-Mediated Anti-Viral Drug Delivery Across Blood–Brain Barrier: Can Lipid Droplet Target Be Game Changers?
Lipid droplets (LDs) are subcellular organelles secreted from the endoplasmic reticulum (ER) that play a major role in lipid homeostasis. Recent...
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Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus
PurposeNLRC4-associated autoinflammatory disease (NLRC4-AID) is an autosomal dominant condition presenting with a range of clinical manifestations...
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Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer
The gastrointestinal tract is a complex interface between the external environment and the immune system. Its ability to control uptake across the...
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The Immune Barrier: Influence of Food Components on the Intestinal Barrier
The skin and mucous membranes of the body constitute the first defense element of the immune system. Single- to multilayered epithelial end tissues...
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Influence of polyethylene terephthalate (PET) microplastic on selected active substances in the intramural neurons of the porcine duodenum
BackgroundCurrently, society and industry generate huge amounts of plastics worldwide. The ubiquity of microplastics is obvious, but its impact on...
