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LncRNA ANRIL promotes HR repair through regulating PARP1 expression by sponging miR-7-5p in lung cancer
BackgroundRadiotherapy is an important treatment for lung cancer, mainly by triggering DNA double-strand breaks to induce cell death. Blocking DNA...
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Biological roles of SLC16A1-AS1 lncRNA and its clinical impacts in tumors
Recent studies have increasingly highlighted the aberrant expression of SLC16A1-AS1 in a variety of tumor types, where it functions as either an...
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Unlocking the diagnostic power of plasma extracellular vesicle miR-200 family in pancreatic ductal adenocarcinoma
BackgroundDistinguishing benign from malignant pancreaticobiliary disease is challenging because of the absence of reliable biomarkers. Circulating...
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Extracellular Vesicles and Obesity
Extracellular vesicles (EVs) are a group of vesicles with membrane structure released by cells, including exosomes, microvesicles, apoptotic bodies,...
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Pan-cancer onco-signatures reveal a novel mitochondrial subtype of luminal breast cancer with specific regulators
BackgroundSomatic alterations in cancer cause dysregulation of signaling pathways that control cell-cycle progression, apoptosis, and cell growth....
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Research progress on the role of extracellular vesicles in neurodegenerative diseases
Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease, affect...
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Sodium Houttuyfonate Ameliorates DSS-induced Colitis Aggravated by Candida albicans through Dectin-1/NF-κB/miR-32-5p/NFKBIZ Axis Based on Intestinal microRNA Profiling
Our previous research indicated that Sodium houttuyfonate (SH) can effectively ameliorate dextran sulfate sodium (DSS)-induced colitis exacerbated by C...
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MicroRNA signature from extracellular vesicles of HCV/HIV co-infected individuals differs from HCV mono-infected
AbstractHepatitis C virus (HCV) coinfection with human immunodeficiency virus (HIV) has a detrimental impact on disease progression. Increasing...
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Role of MicroRNAs in Stroke Pathology and Recovery
Ischemic stroke is a leading cause of morbidity and mortality all over the world. Stem cell-based therapies have become a popular choice with...
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Vilazodone Alleviates Neurogenesis-Induced Anxiety in the Chronic Unpredictable Mild Stress Female Rat Model: Role of Wnt/β-Catenin Signaling
Defective β-catenin signaling is accompanied with compensatory neurogenesis process that may pave to anxiety. β-Catenin has a distinct role in...
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Sex-biased gene and microRNA expression in the develo** mouse brain is associated with neurodevelopmental functions and neurological phenotypes
BackgroundSex differences pose a challenge and an opportunity in biomedical research. Understanding how sex chromosomes and hormones affect...
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Loss of microRNA-21 protects against acetaminophen-induced hepatotoxicity in mice
Acetaminophen (APAP)-induced Acute Liver Failure (ALF) is recognized as the most common cause of ALF in Western societies. APAP-induced ALF is...
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miRNAs in pancreatic cancer progression and metastasis
Small non-coding RNA or microRNA (miRNA) are critical regulators of eukaryotic cells. Dysregulation of miRNA expression and function has been linked...
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Differential Gene Expression Profiles Involved in the Inflammations Due to COVID-19 and Inflammatory Bowel Diseases and the Investigation of Predictive Biomarkers
Gastrointestinal manifestations in COVID-19 were attributed to 74–86% of the hospitalised patients due to severe or prolonged pathogenesis. Though it...
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Analysis of circulating extracellular vesicle derived microRNAs in breast cancer patients with obesity: a potential role for Let-7a
BackgroundThe incidence of obesity, a known risk factor for several metabolic and chronic diseases, including numerous malignancies, has risen...
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Interaction of lncRNAs with mTOR in colorectal cancer: a systematic review
Colorectal cancer (CRC) is the third most widespread cancer and the fourth leading lethal disease among different societies. It is thought that CRC...
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MicroRNA Regulatory Pattern in Diabetic Mouse Cortex at Different Stages Following Ischemic Stroke
After ischemic stroke, microRNAs (miRNAs) participate in various processes, including immune responses, inflammation, and angiogenesis. Diabetes is a...
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Changes in Renin Angiotensin System (RAS) in Cancers and Lung Diseases: Application of Biosensors for Monitoring These Changes
In humans, almost every organ has varying degrees of the functional renin-angiotensin system (RAS). Increased RAS activity has been shown in various...
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LncRNA-m18as1 competitively binds with miR-18a-5p to regulate follicle-stimulating hormone secretion through the Smad2/3 pathway in rat primary pituitary cells
Long noncoding RNAs (lncRNAs) are expressed in different species and different tissues, and perform different functions, but little is known about...
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The Effects of Transcranial Focused Ultrasound Stimulation of Nucleus Accumbens on Neuronal Gene Expression and Brain Tissue in High Alcohol-Preferring Rats
We investigated the effect of low-intensity focused ultrasound (LIFU) on gene expression related to alcohol dependence and histological effects on...
