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Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches
Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy...
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Age-Related Features of Ketanserin Effects in Experimental Liver Cirrhosis
The effect of ketanserin on inflammation, liver fibrosis, and microviscosity of the plasma and mitochondrial membranes of hepatocytes was studied on...
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Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3
BackgroundLiver metastasis is the leading cause of death in patients with colorectal cancer (CRC). Surgical resection of the liver metastases...
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Sesamol protects against liver fibrosis induced in rats by modulating lysophosphatidic acid receptor expression and TGF-β/Smad3 signaling pathway
The present study aimed to investigate the hepatoprotective effect of sesamol (SML), a nutritional phenolic compound obtained from sesame seeds, in...
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Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration
Endogenous β cell regeneration could alleviate diabetes, but proliferative stimuli within the islet microenvironment are incompletely understood. We...
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Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights
The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of liver metastases were established in 2017. Since then,...
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Gene Therapy in Liver Disease: Challenges and Outcomes
Liver-directed gene therapy (LDGT) has been proposed as a means of treating many single-gene inherited disorders. LDGT has been used to create...
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PBTK modeling of the pyrrolizidine alkaloid retrorsine to predict liver toxicity in mouse and rat
Retrorsine is a hepatotoxic pyrrolizidine alkaloid (PA) found in herbal supplements and medicines, food and livestock feed. Dose-response studies...
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LY6D is crucial for lipid accumulation and inflammation in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a serious metabolic disorder characterized by excess fat accumulation in the liver. Over the past decade,...
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Role of the Hippo pathway in liver regeneration and repair: recent advances
Although the signaling pathways involved in normal liver regeneration have been well characterized, less has been done for livers affected by chronic...
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Macrophage-specific FGFR1 deletion alleviates high-fat-diet-induced liver inflammation by inhibiting the MAPKs/TNF pathways
Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disease that is substantially associated with obesity-induced chronic inflammation....
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Therapeutic Potential of MicroRNAs and Their Nanoparticle-based Delivery in the Treatment of Liver Fibrosis
Chronic liver disease is a global health problem owing to its high morbidity and the limited available treatment options. Liver fibrosis, the most...
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Mesenchymal stem cells-based therapy in liver diseases
Multiple immune cells and their products in the liver together form a complex and unique immune microenvironment, and preclinical models have...
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Therapeutic potential of traditional Chinese medicine for vascular endothelial growth factor
Vascular endothelial growth factor (VEGF) is the main regulator of physiological angiogenesis during embryonic development, bone growth, and...
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BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF
AbstractThe BMP/TGFβ-Smad, Notch and VEGF signaling guides formation of endothelial tip and stalk cells. However, the crosstalk of bone morphogenetic...
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Endothelial heterogeneity and plasticity
Vascular endothelial cells are highly plastic and show great phenotypic heterogeneity. In recent years, emerging technologies have identified a range...
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Gemcitabine-loaded synthetic high-density lipoprotein preferentially eradicates hepatic monocyte-derived macrophages in mouse liver with colorectal cancer metastases
Liver metastasis of colorectal cancer (CRC) is the critical cause of CRC-related death due to its unique immunosuppressive microenvironment. In this...
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The glycolytic process in endothelial cells and its implications
Endothelial cells play an obligatory role in regulating local vascular tone and maintaining homeostasis in vascular biology. Cell metabolism,...
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The Immune System in Liver Cancer: From Beginning to Progression
Hepatocellular carcinoma is one of the deadliest cancers in the world; it is a disease that develops due to different etiologies. As a result of...
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Notch Signaling and Liver Cancer
Interactions between liver cells are closely regulated by Notch signaling. Notch signaling has been reported clinically related to bile duct...