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Hypothalamus
A major function of the nervous system is to maintain the constancy of the internal environment. In 1878, Claude Bernard pointed out the remarkable...
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Pulmonary arterial hypertension: the case for a bioelectronic treatment
Pulmonary arterial hypertension (PAH) is a rare disease of unknown etiology that progresses to right ventricular failure. It has a complex...
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The Mouse Cerebral Cortex
The cerebral cortex is the hierarchically highest unit of the mammalian brain. The entire afferent sensory information (somatosensory, visual,...
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Ethnobotany, Phytochemistry and Pharmacological Features of Centella asiatica: A Comprehensive Review
Centella asiatica (CA) or Gotu cola is an herbal plant from the Apiaceae family with a long history of usage in different traditional medicines. It...
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Morphological Features of Astrocytes in Health and Neuropsychiatric Disorders
Astroglial cells actively partner with several cell types to regulate the arrangement of neuronal circuits both in the develo** and adult brain....
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Exome-wide evaluation of rare coding variants using electronic health records identifies new gene–phenotype associations
The clinical impact of rare loss-of-function variants has yet to be determined for most genes. Integration of DNA sequencing data with electronic...
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Cortical Representation of Touch in Silico
With its six layers and ~ 12,000 neurons, a cortical column is a complex network whose function is plausibly greater than the sum of its...
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Untangling the cortico-thalamo-cortical loop: cellular pieces of a knotty circuit puzzle
Functions of the neocortex depend on its bidirectional communication with the thalamus, via cortico-thalamo-cortical (CTC) loops. Recent work...
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Predictive Role of the Cervical Sympathetic Trunk Ischemia on Lower Heart Rates in an Experimentally Induced Stenoocclusive Carotid Artery Model by Bilateral Common Carotid Artery Ligation
Bilateral common carotid artery ligation (BCCAL) leads to acute craniocervicocerebral ischemia, retrograde blood flow, increased blood pressure, and...
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Pre-Brodmann pioneers of cortical cytoarchitectonics II: Carl Hammarberg, Alfred Walter Campbell and Grafton Elliot Smith
The present study and the preceding paper revisit landmark discoveries that paved the way to the definition of the renowned Brodmann areas in the...
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Treating Post-traumatic Stress Disorder with Neuromodulation Therapies: Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation, and Deep Brain Stimulation
Post-traumatic stress disorder (PTSD) is a prevalent and debilitating illness. While standard treatment with pharmacotherapy and psychotherapy may be...
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Overview of the Human Brain and Spinal Cord
During the last decades, there have been tremendous technical developments to study the human central nervous system (CNS) and its connectivity....
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Development and Developmental Disorders of the Cerebral Cortex
The cerebral cortex can be divided into a large isocortex, a much smaller allocortex (the hippocampal formation and the olfactory cortex), and a...
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Nerves in cancer
The contribution of nerves to the pathogenesis of malignancies has emerged as an important component of the tumour microenvironment. Recent studies...
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Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson’s disease patients
AbstractIn Parkinson’s disease (PD) there is widespread accumulation in the brain of abnormal α-synuclein aggregates forming intraneuronal Lewy...
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Hormonal axes in Drosophila: regulation of hormone release and multiplicity of actions
Hormones regulate development, as well as many vital processes in the daily life of an animal. Many of these hormones are peptides that act at a...
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cGMP: a unique 2nd messenger molecule – recent developments in cGMP research and development
Cyclic guanosine monophosphate (cGMP) is a unique second messenger molecule formed in different cell types and tissues. cGMP targets a variety of...
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The biology of SCUBE
The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial growth factor domain-containing protein] family consists of three proteins...
