Search
Search Results
-
Modeling population pharmacokinetics of morniflumate in healthy Korean men: extending pharmacometrics analysis to niflumic acid, its major active metabolite
This study aimed to quantify and explain inter-subject variability in morniflumate pharmacokinetics and identify effective covariates through...
-
Effects of older age on visual and self-motion sensory cue integration in navigation
Older adults demonstrate impairments in navigation that cannot be explained by general cognitive and motor declines. Previous work has shown that...
-
Integrating physiologically based kinetic (PBK) and Monte Carlo modelling to predict inter-individual and inter-ethnic variation in bioactivation and liver toxicity of lasiocarpine
The aim of the present study was to predict the effect of inter-individual and inter-ethnic human kinetic variation on the sensitivity towards acute...
-
Day to Day Consistency and Inter-subject Variability of Neuromuscular Responses and Performance Fatigability as the Result of Maximal, Bilateral, Dynamic Leg Extensions
PurposeThe purpose of the present study was to examine the day-to-day consistency and inter-subject variability of composite and individual,...
-
Validation of a non-linear index of heart rate variability to determine aerobic and anaerobic thresholds during incremental cycling exercise in women
Studies highlight the usage of non-linear time series analysis of heart rate variability (HRV) using the short-term scaling exponent alpha1 of...
-
Repeatability and Variability of the 3-Min All-Out Test at the Subject Level
PurposeThe constant work-rate to exhaustion tests must be repeated several times at each work-rate to estimate subject-level trial-to-trial variance...
-
Optimized reagents for immunopotency assays on mesenchymal stromal cells for clinical use
AbstractMultipotent mesenchymal stromal cells (MSC) offer new therapeutic opportunities based on their ability to modulate an imbalanced immune...
-
The Associations Between Grey Matter Volume Covariance Patterns and Gait Variability—The Tasmanian Study of Cognition and Gait
Greater gait variability predicts dementia. However, little is known about the neural correlates of gait variability. The aims of this study were to...
-
The effect of analyst training on fecal egg counting variability
Fecal egg counts (FECs) are essential for veterinary parasite control programs. Recent advances led to the creation of an automated FEC system that...
-
Intra- and inter- individual rivaroxaban concentrations and potential bleeding risk in patients with atrial fibrillation
BackgroundRoutine laboratory monitoring of rivaroxaban and dose adjustment relating to exposure is currently not recommended. However, in certain...
-
Population Pharmacokinetic Model of Methotrexate in Brazilian Pediatric Patients with Acute Lymphoblastic Leukemia
ObjectivesMethotrexate (MTX) is subject to therapeutic drug monitoring because of its high pharmacokinetic variability and safety risk outside the...
-
Variation of tafamidis plasma levels during the treatment of TTR amyloidosis patients with Glu89Gln mutation
PurposeThe transthyretin kinetic stabilizer tafamidis, used as a first-line therapy of amyloidosis patients, binds selectively to the transthyretin...
-
Modeling inter-trial variability of pointing movements during visuomotor adaptation
Trial-to-trial variability during visuomotor adaptation is usually explained as the result of two different sources, planning noise and execution...
-
Proof of Concept in Assignment of Within-Subject Variability During Virtual Bioequivalence Studies: Propagation of Intra-Subject Variation in Gastrointestinal Physiology Using Physiologically Based Pharmacokinetic Modeling
While the concept of ‘Virtual Bioequivalence’ (VBE) using a combination of modelling, in vitro tests and integration of pre-existing data on systems...
-
A whole-slide image grading benchmark and tissue classification for cervical cancer precursor lesions with inter-observer variability
The cervical cancer develo** from the precancerous lesions caused by the human papillomavirus (HPV) has been one of the preventable cancers with...
-
Metaplastic neuromodulation via transcranial direct current stimulation has no effect on corticospinal excitability and neuromuscular fatigue
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation tool with potential for managing neuromuscular fatigue, possibly...
-
Pharmacokinetics of oral spironolactone in infants up to 2 years of age
PurposeSpironolactone is a potassium sparing diuretic used for decades. Until now, pharmacokinetic (PK) studies of spironolactone have not been...
-
An individualized digital twin of a patient for transdermal fentanyl therapy for chronic pain management
Fentanyl transdermal therapy is a suitable treatment for moderate-to-severe cancer-related pain. The inter-individual variability of the patients...
-
Assessment of body mass-related covariates for rifampicin pharmacokinetics in healthy Caucasian volunteers
PurposeCurrently, body weight-based dosing of rifampicin is recommended. But lately, fat-free mass (FFM) was reported to be superior to body weight...
-
An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models
BackgroundThe understanding of inhaled particle respiratory tract deposition is a key link to understand the health effects of particles or the...
