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Histopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis
BackgroundThe TNM system is used to assess prognosis after colorectal cancer (CRC) diagnosis. Other prognostic factors reported include...
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Gene expression and immune infiltration in melanoma patients with different mutation burden
BackgroundImmunotherapy is a vital component in cancer treatment. However, due to the complex genetic bases of cancer, a clear prediction index for...
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Spatial distribution pattern of immune cells is associated with patient prognosis in colorectal cancer
BackgroundThe spatial context of tumor-infiltrating immune cells (TIICs) is important in predicting colorectal cancer (CRC) patients’ clinical...
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Artificial intelligence for quantifying immune infiltrates interacting with stroma in colorectal cancer
BackgroundWe proposed an artificial intelligence-based immune index, Deep-immune score, quantifying the infiltration of immune cells interacting with...
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Overview of Basic Immunology and Clinical Application
Tumor exists as a complex network of structures with an ability to evolve and evade the host immune surveillance mechanism. The immune milieu which...
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The inflammatory pathogenesis of colorectal cancer
The mutational landscape of colorectal cancer (CRC) does not enable predictions to be made about the survival of patients or their response to...
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Identification of immunotherapy-related lncRNA signature for predicting prognosis, immunotherapy responses and drug candidates in bladder cancer
BackgroundBladder cancer (BC) is one of the most common malignant diseases and the most common causes of cancer death worldwide. Immunotherapy has...
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DeepRisk network: an AI-based tool for digital pathology signature and treatment responsiveness of gastric cancer using whole-slide images
BackgroundDigital histopathology provides valuable information for clinical decision-making. We hypothesized that a deep risk network (DeepRisk)...
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Hypoxia and the phenomenon of immune exclusion
Over the last few years, cancer immunotherapy experienced tremendous developments and it is nowadays considered a promising strategy against many...
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ISG15 targets glycosylated PD-L1 and promotes its degradation to enhance antitumor immune effects in lung adenocarcinoma
BackgroundImmunocheckpoint inhibitors (ICIs) have been widely used in the clinical treatment of lung cancer. Although clinical studies and trials...
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Glucose transporter 3 (GLUT3) promotes lactylation modifications by regulating lactate dehydrogenase A (LDHA) in gastric cancer
ObjectivesGlucose transporter 3 (GLUT3) plays a major role in glycolysis and glucose metabolism in cancer cells. We aimed to investigate the...
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Enlarged tumour-draining lymph node with immune-activated profile predict favourable survival in non-metastatic colorectal cancer
BackgroundThe tumour-draining lymph node (TDLN) plays a pivotal role in the suppression of malignant tumour, however, the immunological profile and...
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Spatial heterogeneity of tumor microenvironment influences the prognosis of clear cell renal cell carcinoma
BackgroundClear cell renal cell carcinoma (ccRCC) is an immunologically and histologically diverse tumor. However, how the structural heterogeneity...
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Enhanced Tumoral MLH1-Expression in MLH1-/PMS2-Deficient Colon Cancer Is Indicative of Sporadic Colon Cancer and Not HNPCC
Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is caused by germline mutations of mismatch-repair (MMR) genes MLH1, MSH2, MSH6 and PMS2....
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Deep Learning for Histopathological Image Analysis
Anatomical Pathology dates back to the nineteenth century when Rudolf Virchow introduced his concept of cellular pathology and when the technical...
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Single-cell high-dimensional imaging mass cytometry: one step beyond in oncology
Solid tumors have a dynamic ecosystem in which malignant and non-malignant (endothelial, stromal, and immune) cell types constantly interact....
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TAP1, a potential immune-related prognosis biomarker with functional significance in uveal melanoma
BackgroundTAP1 is an immunomodulation-related protein that plays different roles in various malignancies. This study investigated the transcriptional...
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Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer
Background and aimsThe gut microbiota is implicated in the pathogenesis of colorectal cancer (CRC). We aimed to map the CRC mucosal microbiota and...
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Patient stratification based on urea cycle metabolism for exploration of combination immunotherapy in colon cancer
BackgroundOwing to the low ratio of patients benefitting from immunotherapy, patient stratification becomes necessary. An accurate patient...
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Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers
Mesenchymal gastrointestinal cancers are represented by the gastrointestinal stromal tumors (GISTs) which occur throughout the whole gastrointestinal...
