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Combined extract of heated TC1, a heat-killed preparation of Lactobacillus casei and alpha-galactosyl ceramide in a mouse model of cervical cancer
BackgroundNowadays, cancer is the leading cause of death among threats to humanity, necessitating prompt action and preparation. Cervical cancer is...
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Immune inactivation by VISTA predicts clinical outcome and therapeutic benefit in muscle-invasive bladder cancer
BackgroundV domain Immunoglobulin suppressor of T cell activation (VISTA) has been proved to be a novel immune checkpoint molecule that positively...
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Immune Response Profiling of Cocktails of Brugia malayi Vaccine Candidates DIM-1, Calponin and Troponin 1 in BALB/c Mice
PurposeIn search of a vaccine for the control of human lymphatic filariasis (LF) caused by Wuchereria bancrofti , Brugia malayi and B. timori, we...
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Gut microbiota modulation enhances the immune capacity of lizards under climate warming
BackgroundHost-microbial interactions are expected to affect species’ adaptability to climate change but have rarely been explored in ectothermic...
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Anemoside B4 inhibits enterovirus 71 propagation in mice through upregulating 14-3-3 expression and type I interferon responses
Enterovirus 71 (EV71) is the major pathogens of human hand, foot, and mouth disease (HFMD). EV71 efficiently escapes innate immunity responses of the...
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Immunomodulatory effects of β-defensin 2 on macrophages induced immuno-upregulation and their antitumor function in breast cancer
BackgroundMacrophages are mononuclear CD34 + antigen-presenting cells of defense mechanism and play dual roles in tumor burden. The immunomodulatory...
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Influenza a virus NS1 resembles a TRAF3-interacting motif to target the RNA sensing-TRAF3-type I IFN axis and impair antiviral innate immunity
BackgroundInfluenza A virus (IAV) evolves strategies to counteract the host antiviral defense for establishing infection. The influenza A virus (IAV)...
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Pharmacokinetics and Pharmacodynamics of Huanglian-Houpo Decoction Based on Berberine Hydrochloride and Magnolol Against H1N1 Influenza Virus
Background and ObjectivesHuanglian-Houpo decoction (HH), which is recorded in the famous traditional Chinese medicine monograph “Puji Fang,” contains...
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Simvastatin Differentially Modulates Glial Functions in Cultured Cortical and Hypothalamic Astrocytes Derived from Interferon α/β Receptor Knockout mice
Astrocytes have key regulatory roles in central nervous system (CNS), integrating metabolic, inflammatory and synaptic responses. In this regard,...
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Combination chemoradiotherapy with temozolomide, vincristine, and interferon-β might improve outcomes regardless of O6-methyl-guanine-DNA-methyltransferase (MGMT) promoter methylation status in newly glioblastoma
BackgroundThis investigator-initiated, open-label, single-arm, single-institute study was conducted to investigate the effectiveness of induction...
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Peritoneal lavage with Glycyrrhiza glabra is effective in preventing peritoneal adhesion in a rat model
BackgroundIntraperitoneal adhesion formation is a significant problem following surgeries, resulting in substantial clinical and economic...
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MHBSt167 induced autophagy promote cell proliferation and EMT by activating the immune response in L02 cells
BackgroundHepatitis B virus can induce hepatocellular carcinoma (HCC) by inducing a host immune response against infected hepatocytes. C-terminally...
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A novel PDPN antagonist peptide CY12-RP2 inhibits melanoma growth via Wnt/β-catenin and modulates the immune cells
BackgroundPodoplanin (PDPN) is a highly conserved, mucin-type protein specific to the lymphatic system. Overexpression of PDPN is associated with the...
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The occurrence and development of radiation-induced lung injury after interstitial brachytherapy and stereotactic radiotherapy in SD rats
BackgroundTo compare the severity of radiation-induced lung injury (RILI) after the right lung of SD rats received interstitial brachytherapy and...
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Multiplexed Gene Expression as a Characterization of Bioactivity for Interferon Beta (IFN-β) Biosimilar Candidates: Impact of Innate Immune Response Modulating Impurities (IIRMIs)
Recombinant human interferon-β (rhIFN-β) therapy is the first-line treatment in relapsing-remitting forms of multiple sclerosis (MS). The mechanism...
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A Case of Autosomal Recessive Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency with Severe COVID-19
BackgroundInterferons (IFNs) play a crucial role in antiviral immunity. Genetic defects in interferon receptors, IFNs, and auto-antibodies against...
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Type I IFN signaling limits hemorrhage-like disease after infection with Japanese encephalitis virus through modulating a prerequisite infection of CD11b+Ly-6C+ monocytes
BackgroundThe crucial role of type I interferon (IFN-I, IFN-α/β) is well known to control central nervous system (CNS) neuroinflammation caused by...
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Association of early menarche with breast tumor molecular features and recurrence
BackgroundEarly menarche is an established risk factor for breast cancer but its molecular contribution to tumor biology and prognosis remains...
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Promoted CD4+ T cell-derived IFN-γ/IL-10 by photobiomodulation therapy modulates neurogenesis to ameliorate cognitive deficits in APP/PS1 and 3xTg-AD mice
BackgroundThe immune system has been implicated in synaptic plasticity, inflammation, and the progression of Alzheimer's disease (AD). However, there...
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Peste des petits ruminants virus non-structural C protein inhibits the induction of interferon-β by potentially interacting with MAVS and RIG-I
Peste des petits ruminants virus (PPRV) causes an acute and highly contagious disease in domestic and wild small ruminants throughout the world,...
