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Organs-at-risk dose constraints in head and neck intensity-modulated radiation therapy using a dataset from a multi-institutional clinical trial (JCOG1015A1)
BackgroundJCOG1015A1 is an ancillary research study to determine the organ-specific dose constraints in head and neck carcinoma treated with...
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Efficacy of a formulation of sarolaner/moxidectin/pyrantel (Simparica Trio®) for the prevention of Thelazia callipaeda canine eyeworm infection
BackgroundFor a long time known as the oriental eyeworm, Thelazia callipaeda is a zoonotic nematode that infects the eyes of a wide range of...
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Rotavirus C infections in asymptomatic piglets in India, 2009-2013: genoty** and phylogenetic analysis of all genomic segments
Asymptomatic infection with rotavirus C (RVC) was observed in pigs in India, with a detection rate of 20%. Sequencing of the VP6, VP7, and NSP4 genes...
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Duck hepatitis A virus type 1 mediates cell cycle arrest in the S phase
BackgroundDuck hepatitis A virus type 1 (DHAV-1) is one of the most serious pathogens endangering the duck industry. However, there are few studies...
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Astaxanthin suppresses the malignant behaviors of nasopharyngeal carcinoma cells by blocking PI3K/AKT and NF-κB pathways via miR-29a-3p
BackgroundAs a natural extraction, astaxanthin is gaining increasing attention because of its safety and anti-tumor properties. It has been reported...
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Efficacy and complications of microvascular decompression in patients over 70 years with trigeminal neuralgia
ObjectiveTreatment of choice for trigeminal neuralgia (TN) by neurovascular conflict in case of failure of medical treatment is microvascular...
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Epstein–Barr virus immediate-early protein Zta mediates the proliferation and migration of HER2-overexpressing cancer cells
Epstein–Barr virus immediate-early protein Zta plays an active role in altering cellular gene expression, which may be fundamentally linked to the...
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Molecular characterization of human astrovirus infection in children under 5 years of age with acute gastroenteritis in Tehran, Iran, 2021–2022: co-infection with rotavirus
Human astroviruses (HAstVs) are considered important causative pathogens of acute gastroenteritis (AGE) in children under 5 years of age worldwide,...
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Molecular characterization of the whole genome of H9N2 avian influenza virus isolated from Egyptian poultry farms
H9N2 avian influenza viruses (AIVs) affect both poultry and humans on a global level, and they are especially prevalent in Egypt. In this study, we...
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Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity
Modified parental histones are segregated symmetrically to daughter DNA strands during replication and can be inherited through mitosis. How this may...
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Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
Cannabidiol (CBD) is one of the most prevalent and abundant cannabinoids extracted from the plant Cannabis sativa . CBD has been reported to induce...
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The CDK4/6 Inhibitor Palbociclib Induces Cell Senescence of High-grade Serous Ovarian Cancer Through Acetylation of p53
AbstractCell senescence is an anti-cancer strategy following DNA repair and apoptosis, which is associated with the initiation, progression, and...
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LncRNA PGM5-AS1 inhibits non-small cell lung cancer progression by targeting miRNA-423-5p/SLIT2 axis
Non-small cell lung cancer (NSCLC) is a common and aggressive primary malignancy worldwide. Dysregulation of long non-coding RNAs (lncRNAs) has been...
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Integrated multi-omics analyses reveal homology-directed repair pathway as a unique dependency in near-haploid leukemia
Whole chromosome losses resulting in near-haploid karyotypes are found in a rare subgroup of treatment-refractory acute lymphoblastic leukemia. To...
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Melatonin induces apoptosis and cell cycle arrest in cervical cancer cells via inhibition of NF-κB pathway
Cervical cancer is the most prevalent cancer in females. Melatonin, a neurohormone has been documented as a promising therapeutic molecule for...
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Anti-cancer properties of Sansalvamide A, its derivatives, and analogs: an updated review
As peptide-based therapies gain recognition for their potential anti-cancer activity, cyclic peptides like Sansalvamide A, a marine-derived cyclic...
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The metabolic effects of APOL1 in humans
Harboring apolipoprotein L1 (APOL1) variants coded by the G1 or G2 alleles of the APOL1 gene increases the risk for collapsing glomerulopathy, focal...
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Par-4 in Cell Cycle Regulation
Cell cycle must be carefully controlled to ensure genetic materials are replicated once and only once per cycle and equal sister chromatid...
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Paradoxical cancer cell proliferation after FGFR inhibition through decreased p21 signaling in FGFR1-amplified breast cancer cells
Fibroblast growth factors (FGFs) control various cellular functions through fibroblast growth factor receptor (FGFR) activation, including...
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Transcriptional regulation and chromatin dynamics at DNA double-strand breaks
In eukaryotic cells, DNA damage can occur at any time and at any chromatin locus, including loci at which active transcription is taking place. DNA...
