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Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival
BackgroundArray CGH analysis of breast tumors has contributed to the identification of different genomic profiles in these tumors. Loss of DNA repair...
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Preparation of a nano emodin transfersome and study on its anti-obesity mechanism in adipose tissue of diet-induced obese rats
ObjectiveTo describe the preparation of nano emodin transfersome (NET) and investigate its effect on mRNA expression of adipose triglyceride lipase...
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Systems biology of myasthenia gravis, integration of aberrant lncRNA and mRNA expression changes
BackgroundA novel class of transcripts, long non-coding RNAs (lncRNAs), has recently emerged as a key player in several biological processes, and...
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Genetically Encoded Fluorescent Biosensors to Explore AMPK Signaling and Energy Metabolism
Maintenance of energy homeostasis is a basic requirement for cell survival. Different mechanisms have evolved to cope with spatial and temporal...
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Role of estrogen receptor alpha in human cervical cancer-associated fibroblasts: a transcriptomic study
Cancer-Associated Fibroblasts (CAFs) are crucial in genesis and progression of tumors; however, cervical CAFs (C-CAFs) are not well characterized....
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RNA sequencing from human neutrophils reveals distinct transcriptional differences associated with chronic inflammatory states
BackgroundThe transcriptional complexity of mammalian cells suggests that they have broad abilities to respond to specific environmental stimuli and...
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Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression
AbstractTransgenic overexpression of adipose tissue (AT) transducin-like enhancer of split 3 (TLE3) mimicked peroxisome proliferator-activated...
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Prediction of individual immune responsiveness to a candidate vaccine by a systems vaccinology approach
BackgroundWe have previously shown that a candidate idiotype vaccine, based on the IGKV3-20 light chain protein, is able to induce activation of...
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Simple Sequence Repeats in 5′ and 3′ Flanking Sequences of Cell Cycle Genes
Simple sequence repeats (SSRs) are hypermutable, and this instability leads to many disorders. Perhaps it is because of this reason SSRs are...
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Prediction of resistance to chemotherapy in ovarian cancer: a systematic review
BackgroundPatient response to chemotherapy for ovarian cancer is extremely heterogeneous and there are currently no tools to aid the prediction of...
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Expanding the genetic basis of copy number variation in familial breast cancer
IntroductionFamilial breast cancer (fBC) is generally associated with an early age of diagnosis and a higher frequency of disease among family...
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Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses
BackgroundThe circadian clock and cell cycle are two global regulatory systems that have pervasive behavioral and physiological effects on eukaryotic...
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Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma
BackgroundThe acyclic retinoid, peretinoin, has been shown to be effective for suppressing hepatocellular carcinoma (HCC) recurrence after definitive...
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Neisseria meningitidiselicits a pro-inflammatory response involving IκBζ in a human blood-cerebrospinal fluid barrier model
BackgroundThe human-specific, Gram-negative bacterium Neisseria meningitidis ( Nm ) is a leading cause of bacterial meningitis worldwide. The...
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Segregation of late outgrowth endothelial cells into functional endothelial CD34− and progenitor-like CD34+ cell populations
Late outgrowth endothelial cells (OECs) that originate from peripheral blood mononuclear cells ex vivo have phenotypic and functional properties of...
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De novo 2.3 Mb microdeletion of 1q32.2 involving the Van der Woude Syndrome locus
BackgroundVan der Woude syndrome is the most common among syndromes which include cleft lip and/or cleft palate as one of the presentations. It is...
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Mechanisms of amiodarone and valproic acid induced liver steatosis in mouse in vivo act as a template for other hepatotoxicity models
Liver injury is the leading cause of drug-induced toxicity. For the evaluation of a chemical compound to induce toxicity, in this case steatosis or...
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Detection of Oral Cancer Using Salivary Diagnostics
Saliva is a non-invasive and accessible biofluid that provides accurate readouts for the detection of oral cancers. Recent technological advances...
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Short and long term gene expression variation and networking in human proximal tubule cells when exposed to cadmium
Cadmium (Cd 2+ ) is a known nephrotoxin causing tubular necrosis during acute exposure and potentially contributing to renal failure in chronic...
