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Unraveling the enigma of long COVID: novel aspects in pathogenesis, diagnosis, and treatment protocols
Long COVID, now unmistakably identified as a syndromic entity encompassing a complex spectrum of symptoms, demands immediate resolution of its...
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Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity: a protocol for an adaptive recall by genotype study
BackgroundPain is a complex polygenic trait whose common genetic underpinnings are relatively ill-defined due in part to challenges in measuring pain...
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Hepatocellular carcinoma and solid pseudopapillary neoplasm of the pancreas complicating familial adenomatous polyposis: two cases and review of the literature
Familial adenomatous polyposis (FAP) is characterized by colorectal polyposis and extracolonic tumors. Adenocarcinoma of the pancreas and...
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Impact of Obesity on Response to Biologic Therapies in Patients with Inflammatory Bowel Diseases
Approximately 20–40% of patients with inflammatory bowel disease (IBD) are obese. Obesity is associated with inferior outcomes in patients with IBD,...
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Immunologic and Genetic Contributors to CD46-Dependent Immune Dysregulation
Mutations in CD46 predispose to atypical hemolytic uremic syndrome (aHUS) with low penetrance. Factors driving immune-dysregulatory disease in...
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The prognostic potential of alkaline phosphatase and lactic acid dehydrogenase in bmCRPC patients without significant PSA response under enzalutamide
BackgroundIn patients with bone metastatic castration-resistant prostate cancer (bmCRPC) on systemic treatment, it is difficult to differentiate...
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The Pharmacokinetic Profile of Palovarotene: An Open-Label Phase I Trial Investigating the Effect of Food and Potential for Drug–Drug Interaction in Healthy Participants
Background and ObjectivesPalovarotene is under development for the treatment of fibrodysplasia ossificans progressiva (FOP). The objectives of this...
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Emerging racial disparities among Medicare beneficiaries and Veterans with metastatic castration-sensitive prostate cancer
BackgroundPrevious studies have shown that Black men receive worse prostate cancer care than White men. This has not been explored in metastatic...
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A case of refractory systemic lupus erythematosus with monocytosis exhibiting somatic KRAS mutation
BackgroundSystemic lupus erythematosus (SLE), an autoimmune disorder that damages various organ systems, is caused by a combination of genetic and...
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Sphingosine 1-phosphate (S1P) receptor modulators as an induction and maintenance therapy for ulcerative colitis: a systematic review and meta-analysis of randomized controlled trials
Background and objectiveOne sphingosine-1-phosphate (S1P) receptor modulator is approved (ozanimod) and another (etrasimod) is under investigation...
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BETA prime: a first-in-man phase 1 study of AdAPT-001, an armed oncolytic adenovirus for solid tumors
AdAPT-001 is an oncolytic adenovirus (OAV) with a transforming growth factor beta (TGF-ß) trap, which neutralizes the immunosuppressive and...
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Role of booster with BNT162b2 mRNA in SARS-CoV-2 vaccination in patients with rheumatoid arthritis
Only case reports and small clinical series report the effects of booster vaccination with BNT162b2 in patients with rheumatoid arthritis (RA). We...
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Tailored surgery on aggressive osteoblastoma involving the cervicothoracic junction: an oncological and spinal stability long-term follow-up
IntroductionAggressive osteoblastoma (AO) represents a rare tumor with borderline features between benign osteoblastoma and osteosarcoma. Having a...
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Application of interim PET-CT in first-line treatment decision-making for lymphoma
Recent advances in lymphoma treatment have significantly improved the survival of patients; however, the current approaches also have varying side...
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Polypharmacology in Clinical Applications: Respiratory Polypharmacology
The respiratory system is an open system that allows us to breathe, bring oxygen into our bodies (called inspiration or inhalation), and send carbon...
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